UGT1A6
Summary: This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene is active on phenolic and planar compounds. Alternative splicing in the unique 5' end of this gene results in two transcript variants. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| UDP glucuronosyltransferase family 1 member A6 | MIM:606431 | Ensembl:ENSG00000167165 | HGNC:HGNC:12538 | PA37181 | 2q37.1 |
Gene Categories:
DRUGGABLE GENOMEGO terms in UGT1A6
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IDA | GO:0006805 | xenobiotic metabolic process |
| BP | IDA | GO:0052695 | cellular glucuronidation |
| BP | TAS | GO:0052695 | cellular glucuronidation |
| BP | IBA | GO:0052696 | flavonoid glucuronidation |
| BP | IBA | GO:0052697 | xenobiotic glucuronidation |
| CC | IDA | GO:0005783 | endoplasmic reticulum |
| CC | TAS | GO:0005789 | endoplasmic reticulum membrane |
| CC | IEA | GO:0016021 | integral component of membrane |
| CC | IBA | GO:0043231 | intracellular membrane-bounded organelle |
| MF | IDA | GO:0001972 | retinoic acid binding |
| MF | IBA | GO:0008194 | UDP-glycosyltransferase activity |
| MF | IDA | GO:0015020 | glucuronosyltransferase activity |
| MF | TAS | GO:0015020 | glucuronosyltransferase activity |
| MF | IDA | GO:0042803 | protein homodimerization activity |
| MF | IDA | GO:0046982 | protein heterodimerization activity |
Gene expression in normal tissue: UGT1A6
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in UGT1A6
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pharmgkb | PA145011115 | Phenytoin Pathway, Pharmacokinetics |
| pharmgkb | PA165964265 | Valproic Acid Pathway, Pharmacokinetics |
| pharmgkb | PA165986194 | Pathway_PA165986194 -need delete |
| pharmgkb | PA165986279 | Acetaminophen Pathway, Pharmacokinetics |
| pharmgkb | PA2029 | Irinotecan Pathway, Pharmacodynamics |
| humancyc | PWY66-201 | nicotine degradation IV |
| humancyc | PWY66-221 | nicotine degradation III |
| kegg | hsa00040 | Pentose and glucuronate interconversions - Homo sapiens (human) |
| kegg | hsa00053 | Ascorbate and aldarate metabolism - Homo sapiens (human) |
| kegg | hsa00140 | Steroid hormone biosynthesis - Homo sapiens (human) |
| kegg | hsa00830 | Retinol metabolism - Homo sapiens (human) |
| kegg | hsa00860 | Porphyrin and chlorophyll metabolism - Homo sapiens (human) |
| kegg | hsa00980 | Metabolism of xenobiotics by cytochrome P450 - Homo sapiens (human) |
| kegg | hsa00982 | Drug metabolism - cytochrome P450 - Homo sapiens (human) |
| kegg | hsa00983 | Drug metabolism - other enzymes - Homo sapiens (human) |
| kegg | hsa05204 | Chemical carcinogenesis - Homo sapiens (human) |
| wikipathways | WP1604 | Codeine and Morphine Metabolism |
| wikipathways | WP2873 | Aryl Hydrocarbon Receptor Pathway |
| wikipathways | WP2875 | Constitutive Androstane Receptor Pathway |
| wikipathways | WP2876 | Pregnane X Receptor pathway |
| wikipathways | WP2882 | Nuclear Receptors Meta-Pathway |
| wikipathways | WP2884 | NRF2 pathway |
| wikipathways | WP4010 | Liver steatosis AOP |
| wikipathways | WP408 | Oxidative Stress |
| wikipathways | WP697 | Estrogen metabolism |
| wikipathways | WP698 | Glucuronidation |
| wikipathways | WP702 | Metapathway biotransformation Phase I and II |
| smpdb | SMP00327 | Phenytoin (Antiarrhythmic) Action Pathway |
| smpdb | SMP00640 | Acetaminophen Metabolism Pathway |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-156580 | Phase II - Conjugation of compounds |
| reactome | R-HSA-156588 | Glucuronidation |
| reactome | R-HSA-211859 | Biological oxidations |
| biocarta | arenrf2pathway | oxidative stress induced gene expression via nrf2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in UGT1A6
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.