UHRF1


Summary: This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. It is regarded as a hub protein for the integration of epigenetic information. This gene is up-regulated in various cancers, and it is therefore considered to be a therapeutic target. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene exists on chromosome 12. [provided by RefSeq, Feb 2014].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
ubiquitin like with PHD and ring finger domains 1MIM:607990Ensembl:ENSG00000276043HGNC:HGNC:12556PA3719619p13.3

GO terms in UHRF1


Term TypeEvidence TypeGO Term IDGO Des.
MFIDAGO:0000987proximal promoter sequence-specific DNA binding
MFTASGO:0003700DNA-binding transcription factor activity
MFIDAGO:0004842ubiquitin-protein transferase activity
MFIPIGO:0005515protein binding
MFIDAGO:0008270zinc ion binding
MFIDAGO:0008327methyl-CpG binding
MFISSGO:0031493nucleosomal histone binding
MFIDAGO:0035064methylated histone binding
MFIDAGO:0042393histone binding
MFISSGO:0042802identical protein binding
MFIDAGO:0044729hemi-methylated DNA-binding
MFIBAGO:0061630ubiquitin protein ligase activity
MFISSGO:0061630ubiquitin protein ligase activity
BPIDAGO:0000122negative regulation of transcription by RNA polymerase II
BPIEAGO:0006281DNA repair
BPIEAGO:0006351transcription, DNA-templated
BPIDAGO:0006511ubiquitin-dependent protein catabolic process
BPIEAGO:0007049cell cycle
BPIEPGO:0008283cell proliferation
BPIBAGO:0010216maintenance of DNA methylation
BPIMPGO:0010216maintenance of DNA methylation
BPIBAGO:0010390histone monoubiquitination
BPISSGO:0010390histone monoubiquitination
BPIBAGO:0016567protein ubiquitination
BPIDAGO:0016574histone ubiquitination
BPIDAGO:0032270positive regulation of cellular protein metabolic process
BPICGO:0045944positive regulation of transcription by RNA polymerase II
BPIDAGO:0051865protein autoubiquitination
BPICGO:2000373positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity
CCIDAGO:0000790nuclear chromatin
CCISSGO:0000790nuclear chromatin
CCIDAGO:0000791euchromatin
CCIDAGO:0000792heterochromatin
CCIDAGO:0005634nucleus
CCIDAGO:0005657replication fork
CCIBAGO:0005720nuclear heterochromatin
CCISSGO:0016363nuclear matrix

Gene expression in normal tissue: UHRF1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in UHRF1


DatabasePathway IDPathway Des.
reactomeR-HSA-212165Epigenetic regulation of gene expression
reactomeR-HSA-5334118DNA methylation
reactomeR-HSA-74160Gene expression (Transcription)
wikipathwaysWP2004miR-targeted genes in lymphocytes - TarBase
wikipathwaysWP2005miR-targeted genes in muscle cell - TarBase
wikipathwaysWP3651Pathways Affected in Adenoid Cystic Carcinoma

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD68Paclitaxel2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in UHRF1

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