UHRF2
Summary: This gene encodes a nuclear protein which is involved in cell-cycle regulation. The encoded protein is a ubiquitin-ligase capable of ubiquinating PCNP (PEST-containing nuclear protein), and together they may play a role in tumorigenesis. The encoded protein contains an NIRF_N domain, a PHD finger, a set- and ring-associated (SRA) domain, and a RING finger domain and several of these domains have been shown to be essential for the regulation of cell proliferation. This protein may also have a role in intranuclear degradation of polyglutamine aggregates. Alternative splicing results in multiple transcript variants some of which are non-protein coding. [provided by RefSeq, Feb 2012].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| ubiquitin like with PHD and ring finger domains 2 | MIM:615211 | Ensembl:ENSG00000147854 | HGNC:HGNC:12557 | PA37197 | 9p24.1 |
Gene Categories:
TUMOR SUPPRESSORGO terms in UHRF2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005720 | nuclear heterochromatin |
| CC | ISS | GO:0005720 | nuclear heterochromatin |
| BP | IEA | GO:0007049 | cell cycle |
| BP | IEP | GO:0008283 | cell proliferation |
| BP | IBA | GO:0010216 | maintenance of DNA methylation |
| BP | IBA | GO:0016567 | protein ubiquitination |
| BP | IDA | GO:0016567 | protein ubiquitination |
| BP | IEP | GO:0030154 | cell differentiation |
| BP | TAS | GO:0051726 | regulation of cell cycle |
| BP | IDA | GO:0051865 | protein autoubiquitination |
| BP | IDA | GO:0071158 | positive regulation of cell cycle arrest |
| MF | IEA | GO:0003677 | DNA binding |
| MF | IDA | GO:0004842 | ubiquitin-protein transferase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | ISS | GO:0042393 | histone binding |
| MF | IEA | GO:0046872 | metal ion binding |
| MF | IBA | GO:0061630 | ubiquitin protein ligase activity |
| MF | IDA | GO:0061630 | ubiquitin protein ligase activity |
Gene expression in normal tissue: UHRF2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in UHRF2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-2990846 | SUMOylation |
| reactome | R-HSA-3108232 | SUMO E3 ligases SUMOylate target proteins |
| reactome | R-HSA-3899300 | SUMOylation of transcription cofactors |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-597592 | Post-translational protein modification |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in UHRF2
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