UNC5A


Summary: UNC5A belongs to a family of netrin-1 (MIM 601614) receptors thought to mediate the chemorepulsive effect of netrin-1 on specific axons. For more information on UNC5 proteins, see UNC5C (MIM 603610).[supplied by OMIM, Apr 2004].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
unc-5 netrin receptor AMIM:607869Ensembl:ENSG00000113763HGNC:HGNC:12567PA372045q35.2

GO terms in UNC5A


Term TypeEvidence TypeGO Term IDGO Des.
CCTASGO:0005886plasma membrane
CCIEAGO:0016021integral component of membrane
CCISSGO:0031226intrinsic component of plasma membrane
CCISSGO:0032589neuron projection membrane
CCISSGO:0032809neuronal cell body membrane
CCIEAGO:0045121membrane raft
BPIEAGO:0006915apoptotic process
BPTASGO:0007411axon guidance
BPISSGO:0031175neuron projection development
BPIEAGO:0033564anterior/posterior axon guidance
BPISSGO:0038007netrin-activated signaling pathway
MFIEAGO:0005042netrin receptor activity

Gene expression in normal tissue: UNC5A

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in UNC5A


DatabasePathway IDPathway Des.
reactomeR-HSA-109581Apoptosis
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-373752Netrin-1 signaling
reactomeR-HSA-373752Netrin-1 signaling
reactomeR-HSA-418886Netrin mediated repulsion signals
reactomeR-HSA-418889via Dependence Receptors in the absence of ligand
reactomeR-HSA-422475Axon guidance
reactomeR-HSA-422475Axon guidance
reactomeR-HSA-5357769Caspase activation via extrinsic apoptotic signalling pathway
reactomeR-HSA-5357801Programmed Cell Death
kegghsa04360Axon guidance - Homo sapiens (human)
pidnetrin_pathwayNetrin-mediated signaling events

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD30917AAG1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in UNC5A

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