USP11


Summary: Protein ubiquitination controls many intracellular processes, including cell cycle progression, transcriptional activation, and signal transduction. This dynamic process, involving ubiquitin conjugating enzymes and deubiquitinating enzymes, adds and removes ubiquitin. Deubiquitinating enzymes are cysteine proteases that specifically cleave ubiquitin from ubiquitin-conjugated protein substrates. This gene encodes a deubiquitinating enzyme which lies in a gene cluster on chromosome Xp11.23 [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
ubiquitin specific peptidase 11MIM:300050Ensembl:ENSG00000102226HGNC:HGNC:12609PA37235Xp11.3

Gene Categories:

DRUGGABLE GENOMEPROTEASE

GO terms in USP11


Term TypeEvidence TypeGO Term IDGO Des.
MFTASGO:0004197cysteine-type endopeptidase activity
MFIDAGO:0004843thiol-dependent ubiquitin-specific protease activity
MFIPIGO:0005515protein binding
MFTASGO:0036459thiol-dependent ubiquitinyl hydrolase activity
CCIDAGO:0005634nucleus
CCIDAGO:0005654nucleoplasm
CCIEAGO:0005694chromosome
CCIDAGO:0005829cytosol
CCTASGO:0005829cytosol
BPIEAGO:0006511ubiquitin-dependent protein catabolic process
BPIDAGO:0016579protein deubiquitination
BPTASGO:0016579protein deubiquitination

Gene expression in normal tissue: USP11

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in USP11


DatabasePathway IDPathway Des.
reactomeR-HSA-390466Chaperonin-mediated protein folding
reactomeR-HSA-390471Association of TriC/CCT with target proteins during biosynthesis
reactomeR-HSA-391251Protein folding
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-5688426Deubiquitination
reactomeR-HSA-5689880Ub-specific processing proteases
reactomeR-HSA-597592Post-translational protein modification
netpathPathway_TNFalphaTNFalpha

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD30917AAG1
iGMDRD353PD03259012

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in USP11

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