USP13
Summary:
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| ubiquitin specific peptidase 13 | MIM:603591 | Ensembl:ENSG00000058056 | HGNC:HGNC:12611 | PA37237 | 3q26.33 |
GO terms in USP13
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IMP | GO:0006355 | regulation of transcription, DNA-templated |
| BP | IEA | GO:0006511 | ubiquitin-dependent protein catabolic process |
| BP | IEA | GO:0006914 | autophagy |
| BP | IMP | GO:0008283 | cell proliferation |
| BP | IDA | GO:0010506 | regulation of autophagy |
| BP | TAS | GO:0016579 | protein deubiquitination |
| BP | TAS | GO:0030318 | melanocyte differentiation |
| BP | IDA | GO:0035523 | protein K29-linked deubiquitination |
| BP | IDA | GO:0044313 | protein K6-linked deubiquitination |
| BP | IDA | GO:0050821 | protein stabilization |
| BP | IMP | GO:0050821 | protein stabilization |
| BP | IDA | GO:0070536 | protein K63-linked deubiquitination |
| BP | IMP | GO:1904294 | positive regulation of ERAD pathway |
| BP | IMP | GO:1904378 | maintenance of unfolded protein involved in ERAD pathway |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005829 | cytosol |
| MF | IMP | GO:0004197 | cysteine-type endopeptidase activity |
| MF | IDA | GO:0004843 | thiol-dependent ubiquitin-specific protease activity |
| MF | TAS | GO:0004843 | thiol-dependent ubiquitin-specific protease activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0008270 | zinc ion binding |
| MF | IPI | GO:0031625 | ubiquitin protein ligase binding |
| MF | IDA | GO:0036459 | thiol-dependent ubiquitinyl hydrolase activity |
| MF | TAS | GO:0036459 | thiol-dependent ubiquitinyl hydrolase activity |
| MF | IDA | GO:0043130 | ubiquitin binding |
| MF | IPI | GO:0044389 | ubiquitin-like protein ligase binding |
| MF | IPI | GO:0051087 | chaperone binding |
| MF | IDA | GO:0070628 | proteasome binding |
| MF | IDA | GO:1904288 | BAT3 complex binding |
| MF | IMP | GO:1904454 | ubiquitin-specific protease activity involved in positive regulation of ERAD pathway |
Gene expression in normal tissue: USP13
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in USP13
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1257604 | PIP3 activates AKT signaling |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-5688426 | Deubiquitination |
| reactome | R-HSA-5689880 | Ub-specific processing proteases |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-6807070 | PTEN Regulation |
| reactome | R-HSA-8948751 | Regulation of PTEN stability and activity |
| reactome | R-HSA-9006925 | Intracellular signaling by second messengers |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in USP13
CLASSFICATION
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