USP28
Summary: The protein encoded by this gene is a deubiquitinase involved in the DNA damage pathway and DNA damage-induced apoptosis. Overexpression of this gene is seen in several cancers. [provided by RefSeq, Oct 2016].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| ubiquitin specific peptidase 28 | MIM:610748 | Ensembl:ENSG00000048028 | HGNC:HGNC:12625 | PA37250 | 11q23.2 |
GO terms in USP28
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IBA | GO:0000077 | DNA damage checkpoint |
| BP | IMP | GO:0000077 | DNA damage checkpoint |
| BP | IEA | GO:0006281 | DNA repair |
| BP | IEA | GO:0006511 | ubiquitin-dependent protein catabolic process |
| BP | IDA | GO:0006974 | cellular response to DNA damage stimulus |
| BP | IMP | GO:0007265 | Ras protein signal transduction |
| BP | IMP | GO:0008283 | cell proliferation |
| BP | IDA | GO:0010212 | response to ionizing radiation |
| BP | IBA | GO:0016579 | protein deubiquitination |
| BP | IDA | GO:0016579 | protein deubiquitination |
| BP | IMP | GO:0016579 | protein deubiquitination |
| BP | TAS | GO:0016579 | protein deubiquitination |
| BP | IBA | GO:0031647 | regulation of protein stability |
| BP | IMP | GO:0031647 | regulation of protein stability |
| BP | IDA | GO:0034644 | cellular response to UV |
| BP | IDA | GO:0042771 | intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005829 | cytosol |
| CC | IDA | GO:0016604 | nuclear body |
| CC | IDA | GO:0032991 | protein-containing complex |
| MF | IBA | GO:0004197 | cysteine-type endopeptidase activity |
| MF | IBA | GO:0004843 | thiol-dependent ubiquitin-specific protease activity |
| MF | IDA | GO:0004843 | thiol-dependent ubiquitin-specific protease activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IMP | GO:0036459 | thiol-dependent ubiquitinyl hydrolase activity |
| MF | TAS | GO:0036459 | thiol-dependent ubiquitinyl hydrolase activity |
Gene expression in normal tissue: USP28
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in USP28
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-5688426 | Deubiquitination |
| reactome | R-HSA-5689880 | Ub-specific processing proteases |
| reactome | R-HSA-597592 | Post-translational protein modification |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in USP28
CLASSFICATION
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