USP28


Summary: The protein encoded by this gene is a deubiquitinase involved in the DNA damage pathway and DNA damage-induced apoptosis. Overexpression of this gene is seen in several cancers. [provided by RefSeq, Oct 2016].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
ubiquitin specific peptidase 28MIM:610748Ensembl:ENSG00000048028HGNC:HGNC:12625PA3725011q23.2

GO terms in USP28


Term TypeEvidence TypeGO Term IDGO Des.
BPIBAGO:0000077DNA damage checkpoint
BPIMPGO:0000077DNA damage checkpoint
BPIEAGO:0006281DNA repair
BPIEAGO:0006511ubiquitin-dependent protein catabolic process
BPIDAGO:0006974cellular response to DNA damage stimulus
BPIMPGO:0007265Ras protein signal transduction
BPIMPGO:0008283cell proliferation
BPIDAGO:0010212response to ionizing radiation
BPIBAGO:0016579protein deubiquitination
BPIDAGO:0016579protein deubiquitination
BPIMPGO:0016579protein deubiquitination
BPTASGO:0016579protein deubiquitination
BPIBAGO:0031647regulation of protein stability
BPIMPGO:0031647regulation of protein stability
BPIDAGO:0034644cellular response to UV
BPIDAGO:0042771intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
CCIDAGO:0005654nucleoplasm
CCTASGO:0005654nucleoplasm
CCIBAGO:0005829cytosol
CCIDAGO:0016604nuclear body
CCIDAGO:0032991protein-containing complex
MFIBAGO:0004197cysteine-type endopeptidase activity
MFIBAGO:0004843thiol-dependent ubiquitin-specific protease activity
MFIDAGO:0004843thiol-dependent ubiquitin-specific protease activity
MFIPIGO:0005515protein binding
MFIMPGO:0036459thiol-dependent ubiquitinyl hydrolase activity
MFTASGO:0036459thiol-dependent ubiquitinyl hydrolase activity

Gene expression in normal tissue: USP28

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in USP28


DatabasePathway IDPathway Des.
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-5688426Deubiquitination
reactomeR-HSA-5689880Ub-specific processing proteases
reactomeR-HSA-597592Post-translational protein modification

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259011

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in USP28

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