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USP37

Summary:

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
ubiquitin specific peptidase 37		Ensembl:ENSG00000135913	HGNC:HGNC:20063	PA134928706	2q35

Gene Categories:

PROTEASE DRUGGABLE GENOME

GO terms in USP37

Term Type	Evidence Type	GO Term ID	GO Des.
MF	IDA	GO:0004197	cysteine-type endopeptidase activity
MF	IDA	GO:0004843	thiol-dependent ubiquitin-specific protease activity
MF	IPI	GO:0005515	protein binding
MF	IPI	GO:0019901	protein kinase binding
MF	TAS	GO:0036459	thiol-dependent ubiquitinyl hydrolase activity
BP	IBA	GO:0000082	G1/S transition of mitotic cell cycle
BP	IDA	GO:0000082	G1/S transition of mitotic cell cycle
BP	IMP	GO:0006275	regulation of DNA replication
BP	IEA	GO:0006511	ubiquitin-dependent protein catabolic process
BP	IDA	GO:0016579	protein deubiquitination
BP	IMP	GO:0016579	protein deubiquitination
BP	TAS	GO:0016579	protein deubiquitination
BP	IDA	GO:0035871	protein K11-linked deubiquitination
BP	IEA	GO:0051301	cell division
BP	IDA	GO:0071108	protein K48-linked deubiquitination
CC	IBA	GO:0005634	nucleus
CC	IDA	GO:0005634	nucleus
CC	TAS	GO:0005654	nucleoplasm

Gene expression in normal tissue: USP37

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in USP37

Database	Pathway ID	Pathway Des.
reactome	R-HSA-392499	Metabolism of proteins
reactome	R-HSA-5688426	Deubiquitination
reactome	R-HSA-5689880	Ub-specific processing proteases
reactome	R-HSA-597592	Post-translational protein modification

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD353	PD0325901	1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in USP37

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DATATYPES

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