UTY


Summary: This gene encodes a protein containing tetratricopeptide repeats which are thought to be involved in protein-protein interactions. The encoded protein is also a minor histocompatibility antigen which may induce graft rejection of male stem cell grafts. A large number of alternatively spliced transcripts have been observed for this gene, but the full length nature of some of these variants has not been determined. [provided by RefSeq, Apr 2012].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
ubiquitously transcribed tetratricopeptide repeat containing, Y-linkedMIM:400009Ensembl:ENSG00000183878HGNC:HGNC:12638PA37263Yq11.221

Gene Categories:

HISTONE MODIFICATION

GO terms in UTY


Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding
MFIBAGO:0001190transcriptional activator activity, RNA polymerase II transcription factor binding
MFIBAGO:0003682chromatin binding
MFIBAGO:0031490chromatin DNA binding
MFTASGO:0032452histone demethylase activity
MFIBAGO:0043565sequence-specific DNA binding
MFIEAGO:0046872metal ion binding
MFIEAGO:0051213dioxygenase activity
MFIBAGO:0071558histone demethylase activity (H3-K27 specific)
MFIEAGO:0071558histone demethylase activity (H3-K27 specific)
CCIBAGO:0000790nuclear chromatin
CCIBAGO:0005634nucleus
CCTASGO:0005654nucleoplasm
CCIBAGO:0044666MLL3/4 complex
BPIEAGO:0010468regulation of gene expression
BPIEAGO:0055114oxidation-reduction process
BPIEAGO:0071557histone H3-K27 demethylation

Gene expression in normal tissue: UTY

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in UTY


DatabasePathway IDPathway Des.
kegghsa05202Transcriptional misregulation in cancer - Homo sapiens (human)
reactomeR-HSA-3214842HDMs demethylate histones
reactomeR-HSA-3247509Chromatin modifying enzymes
reactomeR-HSA-4839726Chromatin organization

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259011

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in UTY

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