VAMP2


Summary: The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. This gene is thought to participate in neurotransmitter release at a step between docking and fusion. The protein forms a stable complex with syntaxin, synaptosomal-associated protein, 25 kD, and synaptotagmin. It also forms a distinct complex with synaptophysin. It is a likely candidate gene for familial infantile myasthenia (FIMG) because of its map location and because it encodes a synaptic vesicle protein of the type that has been implicated in the pathogenesis of FIMG. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
vesicle associated membrane protein 2MIM:185881Ensembl:ENSG00000220205HGNC:HGNC:12643PA3726717p13.1

GO terms in VAMP2


Term TypeEvidence TypeGO Term IDGO Des.
MFISSGO:0000149SNARE binding
MFIPIGO:0005515protein binding
MFISSGO:0005516calmodulin binding
MFISSGO:0005543phospholipid binding
MFISSGO:0017075syntaxin-1 binding
MFIBAGO:0019905syntaxin binding
MFIPIGO:0019905syntaxin binding
MFISSGO:0019905syntaxin binding
MFTASGO:0043621protein self-association
MFISSGO:0048306calcium-dependent protein binding
CCISSGO:0005802trans-Golgi network
CCTASGO:0005829cytosol
CCISSGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCTASGO:0005887integral component of plasma membrane
CCISSGO:0008021synaptic vesicle
CCTASGO:0008021synaptic vesicle
CCISSGO:0008076voltage-gated potassium channel complex
CCIDAGO:0016020membrane
CCIEAGO:0030054cell junction
CCIDAGO:0030136clathrin-coated vesicle
CCISSGO:0030141secretory granule
CCTASGO:0030665clathrin-coated vesicle membrane
CCIDAGO:0030667secretory granule membrane
CCTASGO:0030667secretory granule membrane
CCISSGO:0030672synaptic vesicle membrane
CCTASGO:0030672synaptic vesicle membrane
CCIDAGO:0031201SNARE complex
CCTASGO:0031201SNARE complex
CCISSGO:0031410cytoplasmic vesicle
CCIDAGO:0031982vesicle
CCISSGO:0042589zymogen granule membrane
CCISSGO:0043005neuron projection
CCISSGO:0043231intracellular membrane-bounded organelle
CCISSGO:0044306neuron projection terminus
CCISSGO:0045202synapse
CCISSGO:0048471perinuclear region of cytoplasm
CCTASGO:0060203clathrin-sculpted glutamate transport vesicle membrane
CCTASGO:0061202clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane
CCISSGO:0070032synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex
CCISSGO:0070033synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex
CCISSGO:0070044synaptobrevin 2-SNAP-25-syntaxin-1a complex
CCTASGO:0070083clathrin-sculpted monoamine transport vesicle membrane
BPTASGO:0006887exocytosis
BPISSGO:0009749response to glucose
BPTASGO:0014047glutamate secretion
BPISSGO:0015031protein transport
BPISSGO:0016079synaptic vesicle exocytosis
BPTASGO:0016079synaptic vesicle exocytosis
BPISSGO:0016192vesicle-mediated transport
BPISSGO:0017156calcium ion regulated exocytosis
BPISSGO:0017157regulation of exocytosis
BPISSGO:0032869cellular response to insulin stimulus
BPISSGO:0043001Golgi to plasma membrane protein transport
BPIMPGO:0043308eosinophil degranulation
BPIMPGO:0043312neutrophil degranulation
BPIMPGO:0043320natural killer cell degranulation
BPISSGO:0060291long-term synaptic potentiation
BPISSGO:0060627regulation of vesicle-mediated transport
BPTASGO:0061024membrane organization
BPISSGO:0061025membrane fusion
BPISSGO:0065003protein-containing complex assembly
BPIMPGO:0070254mucus secretion
BPISSGO:0090316positive regulation of intracellular protein transport
BPISSGO:1902259regulation of delayed rectifier potassium channel activity
BPIMPGO:1903593regulation of histamine secretion by mast cell

Gene expression in normal tissue: VAMP2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in VAMP2


DatabasePathway IDPathway Des.
pidbotulinumtoxinpathwayEffects of Botulinum toxin
pidinsulin_glucose_pathwayInsulin-mediated glucose transport
kegghsa04130SNARE interactions in vesicular transport - Homo sapiens (human)
kegghsa04721Synaptic vesicle cycle - Homo sapiens (human)
kegghsa04911Insulin secretion - Homo sapiens (human)
kegghsa04962Vasopressin-regulated water reabsorption - Homo sapiens (human)
kegghsa04970Salivary secretion - Homo sapiens (human)
pharmgkbPA162355621Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics
wikipathwaysWP2267Synaptic Vesicle Pathway
wikipathwaysWP481Insulin Signaling
wikipathwaysWP706Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways
reactomeR-HSA-112310Neurotransmitter release cycle
reactomeR-HSA-112315Transmission across Chemical Synapses
reactomeR-HSA-112316Neuronal System
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-1445148Translocation of SLC2A4 (GLUT4) to the plasma membrane
reactomeR-HSA-163685Integration of energy metabolism
reactomeR-HSA-1643685Disease
reactomeR-HSA-168256Immune System
reactomeR-HSA-168799Neurotoxicity of clostridium toxins
reactomeR-HSA-181429Serotonin Neurotransmitter Release Cycle
reactomeR-HSA-181430Norepinephrine Neurotransmitter Release Cycle
reactomeR-HSA-199991Membrane Trafficking
reactomeR-HSA-199991Membrane Trafficking
reactomeR-HSA-199992trans-Golgi Network Vesicle Budding
reactomeR-HSA-210500Glutamate Neurotransmitter Release Cycle
reactomeR-HSA-212676Dopamine Neurotransmitter Release Cycle
reactomeR-HSA-264642Acetylcholine Neurotransmitter Release Cycle
reactomeR-HSA-264876Insulin processing
reactomeR-HSA-2980736Peptide hormone metabolism
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-421837Clathrin derived vesicle budding
reactomeR-HSA-422356Regulation of insulin secretion
reactomeR-HSA-432720Lysosome Vesicle Biogenesis
reactomeR-HSA-432722Golgi Associated Vesicle Biogenesis
reactomeR-HSA-449147Signaling by Interleukins
reactomeR-HSA-449836Other interleukin signaling
reactomeR-HSA-5250955Toxicity of botulinum toxin type D (BoNT/D)
reactomeR-HSA-5250958Toxicity of botulinum toxin type B (BoNT/B)
reactomeR-HSA-5250981Toxicity of botulinum toxin type F (BoNT/F)
reactomeR-HSA-5250982Toxicity of tetanus toxin (TeNT)
reactomeR-HSA-5250989Toxicity of botulinum toxin type G (BoNT/G)
reactomeR-HSA-5339562Uptake and actions of bacterial toxins
reactomeR-HSA-5653656Vesicle-mediated transport
reactomeR-HSA-5653656Vesicle-mediated transport
reactomeR-HSA-5663205Infectious disease
reactomeR-HSA-8856825Cargo recognition for clathrin-mediated endocytosis
reactomeR-HSA-8856828Clathrin-mediated endocytosis
reactomeR-HSA-888590GABA synthesis, release, reuptake and degradation

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259012

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in VAMP2

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