Summary: Vasodilator-stimulated phosphoprotein (VASP) is a member of the Ena-VASP protein family. Ena-VASP family members contain an EHV1 N-terminal domain that binds proteins containing E/DFPPPPXD/E motifs and targets Ena-VASP proteins to focal adhesions. In the mid-region of the protein, family members have a proline-rich domain that binds SH3 and WW domain-containing proteins. Their C-terminal EVH2 domain mediates tetramerization and binds both G and F actin. VASP is associated with filamentous actin formation and likely plays a widespread role in cell adhesion and motility. VASP may also be involved in the intracellular signaling pathways that regulate integrin-extracellular matrix interactions. VASP is regulated by the cyclic nucleotide-dependent kinases PKA and PKG. [provided by RefSeq, Jul 2008].

vasodilator stimulated phosphoproteinMIM:601703Ensembl:ENSG00000125753HGNC:HGNC:12652PA3727619q13.32

GO terms in VASP

Term TypeEvidence TypeGO Term IDGO Des.
BPIEAGO:0001843neural tube closure
BPTASGO:0007411axon guidance
BPIEAGO:0008154actin polymerization or depolymerization
BPIDAGO:0030838positive regulation of actin filament polymerization
BPTASGO:0034329cell junction assembly
BPIEAGO:0051289protein homotetramerization
CCIDAGO:0005886plasma membrane
CCIEAGO:0005923bicellular tight junction
CCHDAGO:0005925focal adhesion
CCIDAGO:0005925focal adhesion
CCTASGO:0015629actin cytoskeleton
CCIEAGO:0031258lamellipodium membrane
CCIEAGO:0031527filopodium membrane
CCHDAGO:0070062extracellular exosome
MFIEAGO:0003779actin binding
MFIPIGO:0005515protein binding
MFIPIGO:0005522profilin binding
MFIEAGO:0017124SH3 domain binding
MFHDAGO:0045296cadherin binding

Gene expression in normal tissue: VASP

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in VASP

DatabasePathway IDPathway Des.
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1280218Adaptive Immune System
reactomeR-HSA-1500931Cell-Cell communication
reactomeR-HSA-168256Immune System
reactomeR-HSA-202403TCR signaling
reactomeR-HSA-202433Generation of second messenger molecules
reactomeR-HSA-376176Signaling by ROBO receptors
reactomeR-HSA-376176Signaling by ROBO receptors
reactomeR-HSA-422475Axon guidance
reactomeR-HSA-422475Axon guidance
reactomeR-HSA-446353Cell-extracellular matrix interactions
reactomeR-HSA-446728Cell junction organization
wikipathwaysWP185Integrin-mediated Cell Adhesion
wikipathwaysWP306Focal Adhesion
pidecadherin_keratinocyte_pathwayE-cadherin signaling in keratinocytes
pidecadherin_stabilization_pathwayStabilization and expansion of the E-cadherin adherens junction
pidil8cxcr2_pathwayIL8- and CXCR2-mediated signaling events
pidthrombin_par1_pathwayPAR1-mediated thrombin signaling events
kegghsa04015Rap1 signaling pathway - Homo sapiens (human)
kegghsa04022cGMP-PKG signaling pathway - Homo sapiens (human)
kegghsa04510Focal adhesion - Homo sapiens (human)
kegghsa04530Tight junction - Homo sapiens (human)
kegghsa04611Platelet activation - Homo sapiens (human)
kegghsa04666Fc gamma R-mediated phagocytosis - Homo sapiens (human)
kegghsa04670Leukocyte transendothelial migration - Homo sapiens (human)

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in VASP