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VASP

Summary: Vasodilator-stimulated phosphoprotein (VASP) is a member of the Ena-VASP protein family. Ena-VASP family members contain an EHV1 N-terminal domain that binds proteins containing E/DFPPPPXD/E motifs and targets Ena-VASP proteins to focal adhesions. In the mid-region of the protein, family members have a proline-rich domain that binds SH3 and WW domain-containing proteins. Their C-terminal EVH2 domain mediates tetramerization and binds both G and F actin. VASP is associated with filamentous actin formation and likely plays a widespread role in cell adhesion and motility. VASP may also be involved in the intracellular signaling pathways that regulate integrin-extracellular matrix interactions. VASP is regulated by the cyclic nucleotide-dependent kinases PKA and PKG. [provided by RefSeq, Jul 2008].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
vasodilator stimulated phosphoprotein	MIM:601703	Ensembl:ENSG00000125753	HGNC:HGNC:12652	PA37276	19q13.32

GO terms in VASP

Term Type	Evidence Type	GO Term ID	GO Des.
BP	IEA	GO:0001843	neural tube closure
BP	TAS	GO:0007411	axon guidance
BP	IEA	GO:0008154	actin polymerization or depolymerization
BP	IDA	GO:0030838	positive regulation of actin filament polymerization
BP	TAS	GO:0034329	cell junction assembly
BP	IEA	GO:0051289	protein homotetramerization
CC	IDA	GO:0005829	cytosol
CC	TAS	GO:0005829	cytosol
CC	IDA	GO:0005886	plasma membrane
CC	IEA	GO:0005923	bicellular tight junction
CC	HDA	GO:0005925	focal adhesion
CC	IDA	GO:0005925	focal adhesion
CC	TAS	GO:0015629	actin cytoskeleton
CC	IEA	GO:0031258	lamellipodium membrane
CC	IEA	GO:0031527	filopodium membrane
CC	HDA	GO:0070062	extracellular exosome
MF	IEA	GO:0003779	actin binding
MF	IPI	GO:0005515	protein binding
MF	IPI	GO:0005522	profilin binding
MF	IEA	GO:0017124	SH3 domain binding
MF	HDA	GO:0045296	cadherin binding

Gene expression in normal tissue: VASP

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in VASP

Database	Pathway ID	Pathway Des.
reactome	R-HSA-1266738	Developmental Biology
reactome	R-HSA-1266738	Developmental Biology
reactome	R-HSA-1280218	Adaptive Immune System
reactome	R-HSA-1500931	Cell-Cell communication
reactome	R-HSA-168256	Immune System
reactome	R-HSA-202403	TCR signaling
reactome	R-HSA-202433	Generation of second messenger molecules
reactome	R-HSA-376176	Signaling by ROBO receptors
reactome	R-HSA-376176	Signaling by ROBO receptors
reactome	R-HSA-422475	Axon guidance
reactome	R-HSA-422475	Axon guidance
reactome	R-HSA-446353	Cell-extracellular matrix interactions
reactome	R-HSA-446728	Cell junction organization
wikipathways	WP185	Integrin-mediated Cell Adhesion
wikipathways	WP306	Focal Adhesion
pid	ecadherin_keratinocyte_pathway	E-cadherin signaling in keratinocytes
pid	ecadherin_stabilization_pathway	Stabilization and expansion of the E-cadherin adherens junction
pid	il8cxcr2_pathway	IL8- and CXCR2-mediated signaling events
pid	thrombin_par1_pathway	PAR1-mediated thrombin signaling events
netpath	Pathway_EGFR1	EGFR1
netpath	Pathway_TCR	TCR
kegg	hsa04015	Rap1 signaling pathway - Homo sapiens (human)
kegg	hsa04022	cGMP-PKG signaling pathway - Homo sapiens (human)
kegg	hsa04510	Focal adhesion - Homo sapiens (human)
kegg	hsa04530	Tight junction - Homo sapiens (human)
kegg	hsa04611	Platelet activation - Homo sapiens (human)
kegg	hsa04666	Fc gamma R-mediated phagocytosis - Homo sapiens (human)
kegg	hsa04670	Leukocyte transendothelial migration - Homo sapiens (human)

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD353	PD0325901	1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in VASP

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