VASP
Summary: Vasodilator-stimulated phosphoprotein (VASP) is a member of the Ena-VASP protein family. Ena-VASP family members contain an EHV1 N-terminal domain that binds proteins containing E/DFPPPPXD/E motifs and targets Ena-VASP proteins to focal adhesions. In the mid-region of the protein, family members have a proline-rich domain that binds SH3 and WW domain-containing proteins. Their C-terminal EVH2 domain mediates tetramerization and binds both G and F actin. VASP is associated with filamentous actin formation and likely plays a widespread role in cell adhesion and motility. VASP may also be involved in the intracellular signaling pathways that regulate integrin-extracellular matrix interactions. VASP is regulated by the cyclic nucleotide-dependent kinases PKA and PKG. [provided by RefSeq, Jul 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
vasodilator stimulated phosphoprotein | MIM:601703 | Ensembl:ENSG00000125753 | HGNC:HGNC:12652 | PA37276 | 19q13.32 |
GO terms in VASP
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
BP | IEA | GO:0001843 | neural tube closure |
BP | TAS | GO:0007411 | axon guidance |
BP | IEA | GO:0008154 | actin polymerization or depolymerization |
BP | IDA | GO:0030838 | positive regulation of actin filament polymerization |
BP | TAS | GO:0034329 | cell junction assembly |
BP | IEA | GO:0051289 | protein homotetramerization |
CC | IDA | GO:0005829 | cytosol |
CC | TAS | GO:0005829 | cytosol |
CC | IDA | GO:0005886 | plasma membrane |
CC | IEA | GO:0005923 | bicellular tight junction |
CC | HDA | GO:0005925 | focal adhesion |
CC | IDA | GO:0005925 | focal adhesion |
CC | TAS | GO:0015629 | actin cytoskeleton |
CC | IEA | GO:0031258 | lamellipodium membrane |
CC | IEA | GO:0031527 | filopodium membrane |
CC | HDA | GO:0070062 | extracellular exosome |
MF | IEA | GO:0003779 | actin binding |
MF | IPI | GO:0005515 | protein binding |
MF | IPI | GO:0005522 | profilin binding |
MF | IEA | GO:0017124 | SH3 domain binding |
MF | HDA | GO:0045296 | cadherin binding |
Gene expression in normal tissue: VASP
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in VASP
Database | Pathway ID | Pathway Des. |
---|---|---|
reactome | R-HSA-1266738 | Developmental Biology |
reactome | R-HSA-1266738 | Developmental Biology |
reactome | R-HSA-1280218 | Adaptive Immune System |
reactome | R-HSA-1500931 | Cell-Cell communication |
reactome | R-HSA-168256 | Immune System |
reactome | R-HSA-202403 | TCR signaling |
reactome | R-HSA-202433 | Generation of second messenger molecules |
reactome | R-HSA-376176 | Signaling by ROBO receptors |
reactome | R-HSA-376176 | Signaling by ROBO receptors |
reactome | R-HSA-422475 | Axon guidance |
reactome | R-HSA-422475 | Axon guidance |
reactome | R-HSA-446353 | Cell-extracellular matrix interactions |
reactome | R-HSA-446728 | Cell junction organization |
wikipathways | WP185 | Integrin-mediated Cell Adhesion |
wikipathways | WP306 | Focal Adhesion |
pid | ecadherin_keratinocyte_pathway | E-cadherin signaling in keratinocytes |
pid | ecadherin_stabilization_pathway | Stabilization and expansion of the E-cadherin adherens junction |
pid | il8cxcr2_pathway | IL8- and CXCR2-mediated signaling events |
pid | thrombin_par1_pathway | PAR1-mediated thrombin signaling events |
netpath | Pathway_EGFR1 | EGFR1 |
netpath | Pathway_TCR | TCR |
kegg | hsa04015 | Rap1 signaling pathway - Homo sapiens (human) |
kegg | hsa04022 | cGMP-PKG signaling pathway - Homo sapiens (human) |
kegg | hsa04510 | Focal adhesion - Homo sapiens (human) |
kegg | hsa04530 | Tight junction - Homo sapiens (human) |
kegg | hsa04611 | Platelet activation - Homo sapiens (human) |
kegg | hsa04666 | Fc gamma R-mediated phagocytosis - Homo sapiens (human) |
kegg | hsa04670 | Leukocyte transendothelial migration - Homo sapiens (human) |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in VASP