Summary: This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD) that may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. The encoded protein forms the beta subunit of rabconnectin-3 and binds directly with Rab3A GDP/GTP exchange protein and indirectly with Rab3A GDP/GTP activating protein; these proteins are regulators of Rab3 small G protein family members involved in control of the calcium-dependant exocytosis of neurotransmitters. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008].

WD repeat domain 7MIM:613473Ensembl:ENSG00000091157HGNC:HGNC:13490PA3778418q21.31

GO terms in WDR7

Term TypeEvidence TypeGO Term IDGO Des.
CCIEAGO:0008021synaptic vesicle
BPIEAGO:0002244hematopoietic progenitor cell differentiation

Gene expression in normal tissue: WDR7

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in WDR7

DatabasePathway IDPathway Des.

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in WDR7