WRAP53
Summary: This gene encodes an essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex required for telomere synthesis. This protein is enriched in Cajal bodies, nuclear sites of RNP processing that are important for telomerase function. It interacts with dyskerin, TERT and TERC, other components of active telomerase, and with small Cajal body RNAs (scaRNAs), which are involved in modifying splicing RNAs. This mRNA also functions as a p53 antisense transcript, that regulates endogenous p53 mRNA levels and further induction of p53 protein by targeting the 5' untranslated region of p53 mRNA. Alternatively spliced transcript variants which differ only in the 5' UTR have been found for this gene. [provided by RefSeq, Mar 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| WD repeat containing antisense to TP53 | MIM:612661 | Ensembl:ENSG00000141499 | HGNC:HGNC:25522 | PA164727568 | 17p13.1 |
Gene Categories:
RNA DIRECTED DNA POLYMERASEGO terms in WRAP53
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005697 | telomerase holoenzyme complex |
| CC | IDA | GO:0005829 | cytosol |
| CC | IDA | GO:0015030 | Cajal body |
| CC | IMP | GO:0015030 | Cajal body |
| CC | IDA | GO:0016604 | nuclear body |
| BP | IDA | GO:0007004 | telomere maintenance via telomerase |
| BP | IMP | GO:0007004 | telomere maintenance via telomerase |
| BP | TAS | GO:0007004 | telomere maintenance via telomerase |
| BP | IMP | GO:0032203 | telomere formation via telomerase |
| BP | IDA | GO:0051973 | positive regulation of telomerase activity |
| BP | IMP | GO:0051973 | positive regulation of telomerase activity |
| BP | IMP | GO:0090666 | scaRNA localization to Cajal body |
| BP | HMP | GO:0090671 | telomerase RNA localization to Cajal body |
| BP | IMP | GO:0090671 | telomerase RNA localization to Cajal body |
| BP | IMP | GO:1904851 | positive regulation of establishment of protein localization to telomere |
| BP | TAS | GO:1904867 | protein localization to Cajal body |
| MF | IDA | GO:0003723 | RNA binding |
| MF | IPI | GO:0003723 | RNA binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | IDA | GO:0044877 | protein-containing complex binding |
| MF | IPI | GO:0051087 | chaperone binding |
| MF | IPI | GO:0070034 | telomerase RNA binding |
Gene expression in normal tissue: WRAP53
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in WRAP53
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-157579 | Telomere Maintenance |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-171319 | Telomere Extension By Telomerase |
| reactome | R-HSA-180786 | Extension of Telomeres |
| reactome | R-HSA-390466 | Chaperonin-mediated protein folding |
| reactome | R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis |
| reactome | R-HSA-391251 | Protein folding |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-73886 | Chromosome Maintenance |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in WRAP53
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