XDH


Summary: Xanthine dehydrogenase belongs to the group of molybdenum-containing hydroxylases involved in the oxidative metabolism of purines. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Xanthine dehydrogenase can be converted to xanthine oxidase by reversible sulfhydryl oxidation or by irreversible proteolytic modification. Defects in xanthine dehydrogenase cause xanthinuria, may contribute to adult respiratory stress syndrome, and may potentiate influenza infection through an oxygen metabolite-dependent mechanism. [provided by RefSeq, Jan 2014].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
xanthine dehydrogenaseMIM:607633Ensembl:ENSG00000158125HGNC:HGNC:12805PA374042p23.1

Gene Categories:

PROTEASEDRUGGABLE GENOME

GO terms in XDH


Term TypeEvidence TypeGO Term IDGO Des.
BPIDAGO:0001933negative regulation of protein phosphorylation
BPIDAGO:0001937negative regulation of endothelial cell proliferation
BPTASGO:0006195purine nucleotide catabolic process
BPIDAGO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process
BPIEAGO:0007595lactation
BPIBAGO:0009115xanthine catabolic process
BPIDAGO:0009115xanthine catabolic process
BPIDAGO:0010629negative regulation of gene expression
BPIEAGO:0022900electron transport chain
BPIDAGO:0045602negative regulation of endothelial cell differentiation
BPIDAGO:0051898negative regulation of protein kinase B signaling
BPIDAGO:1900745positive regulation of p38MAPK cascade
BPIDAGO:1900747negative regulation of vascular endothelial growth factor signaling pathway
BPIDAGO:2000379positive regulation of reactive oxygen species metabolic process
BPIDAGO:2001213negative regulation of vasculogenesis
CCHDAGO:0005615extracellular space
CCIBAGO:0005615extracellular space
CCIEAGO:0005777peroxisome
CCIBAGO:0005829cytosol
CCTASGO:0005829cytosol
CCIEAGO:0016529sarcoplasmic reticulum
MFIBAGO:0004854xanthine dehydrogenase activity
MFIDAGO:0004854xanthine dehydrogenase activity
MFEXPGO:0004855xanthine oxidase activity
MFIDAGO:0004855xanthine oxidase activity
MFIEAGO:0005506iron ion binding
MFIEAGO:0009055electron transfer activity
MFIEAGO:0016614oxidoreductase activity, acting on CH-OH group of donors
MFIBAGO:0016903oxidoreductase activity, acting on the aldehyde or oxo group of donors
MFIPIGO:0042803protein homodimerization activity
MFIDAGO:0043546molybdopterin cofactor binding
MFIBAGO:0050660flavin adenine dinucleotide binding
MFIDAGO:0050660flavin adenine dinucleotide binding
MFIDAGO:00515372 iron, 2 sulfur cluster binding

Gene expression in normal tissue: XDH

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in XDH


DatabasePathway IDPathway Des.
reactomeR-HSA-1280218Adaptive Immune System
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-15869Metabolism of nucleotides
reactomeR-HSA-168256Immune System
reactomeR-HSA-74259Purine catabolism
reactomeR-HSA-8851680Butyrophilin (BTN) family interactions
reactomeR-HSA-8956319Nucleobase catabolism
wikipathwaysWP15Selenium Micronutrient Network
wikipathwaysWP1995Effects of Nitric Oxide
wikipathwaysWP3633Caffeine and Theobromine metabolism
wikipathwaysWP408Oxidative Stress
smpdbSMP00028Caffeine Metabolism
smpdbSMP00050Purine Metabolism
smpdbSMP00144Adenosine Deaminase Deficiency
smpdbSMP00167Adenylosuccinate Lyase Deficiency
smpdbSMP00168AICA-Ribosiduria
smpdbSMP00203Molybdenum Cofactor Deficiency
smpdbSMP00210Purine Nucleoside Phosphorylase Deficiency
smpdbSMP00220Xanthine Dehydrogenase Deficiency (Xanthinuria)
smpdbSMP00364Lesch-Nyhan Syndrome (LNS)
smpdbSMP00365Gout or Kelley-Seegmiller Syndrome
smpdbSMP00427Azathioprine Action Pathway
smpdbSMP00428Mercaptopurine Action Pathway
smpdbSMP00430Thioguanine Action Pathway
smpdbSMP00512Xanthinuria type I
smpdbSMP00513Xanthinuria type II
smpdbSMP00535Adenine phosphoribosyltransferase deficiency (APRT)
smpdbSMP00536Mitochondrial DNA depletion syndrome
smpdbSMP00537Myoadenylate deaminase deficiency
smpdbSMP00609Mercaptopurine Metabolism Pathway
smpdbSMP00650Doxorubicin Metabolism Pathway
humancycPWY-5695urate biosynthesis/inosine 5,-phosphate degradation
humancycPWY-6353purine nucleotides degradation
humancycPWY-6608guanosine nucleotides degradation
humancycPWY-6875retinoate biosynthesis II
humancycSALVADEHYPOX-PWYadenosine nucleotides degradation
pharmgkbPA165292163Doxorubicin Pathway (Cancer Cell), Pharmacodynamics
pharmgkbPA165292177Doxorubicin Pathway, Pharmacokinetics
pharmgkbPA165884757Caffeine Pathway, Pharmacokinetics
pharmgkbPA165958541Theophylline Pathway, Pharmacokinetics
pharmgkbPA165980774Uric Acid-Lowering Drugs Pathway, Pharmacodynamics
kegghsa00230Purine metabolism - Homo sapiens (human)
kegghsa00232Caffeine metabolism - Homo sapiens (human)
kegghsa00983Drug metabolism - other enzymes - Homo sapiens (human)
kegghsa04146Peroxisome - Homo sapiens (human)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259012

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in XDH

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