ZCCHC12
Summary: This gene encodes a downstream effector of bone morphogenetic protein (BMP) signalling. This protein contains a zinc finger domain and functions as a transcriptional coactivator. Variation in this gene may be associated with X-linked cognitive disability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| zinc finger CCHC-type containing 12 | MIM:300701 | Ensembl:ENSG00000174460 | HGNC:HGNC:27273 | PA134885304 | Xq24 |
GO terms in ZCCHC12
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0003676 | nucleic acid binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0008270 | zinc ion binding |
| MF | IBA | GO:0030374 | nuclear receptor transcription coactivator activity |
| CC | IBA | GO:0016607 | nuclear speck |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | IBA | GO:0030509 | BMP signaling pathway |
| BP | IEA | GO:1903508 | positive regulation of nucleic acid-templated transcription |
Gene expression in normal tissue: ZCCHC12
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ZCCHC12
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | betacatenin_nuc_pathway | Regulation of nuclear beta catenin signaling and target gene transcription |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ZCCHC12
CLASSFICATION
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