ZEB1
Summary: This gene encodes a zinc finger transcription factor. The encoded protein likely plays a role in transcriptional repression of interleukin 2. Mutations in this gene have been associated with posterior polymorphous corneal dystrophy-3 and late-onset Fuchs endothelial corneal dystrophy. Alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Mar 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| zinc finger E-box binding homeobox 1 | MIM:189909 | Ensembl:ENSG00000148516 | HGNC:HGNC:11642 | PA162409589 | 10p11.22 |
GO terms in ZEB1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISM | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | NAS | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IDA | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding |
| MF | IEA | GO:0003682 | chromatin binding |
| MF | TAS | GO:0003700 | DNA-binding transcription factor activity |
| MF | TAS | GO:0003713 | transcription coactivator activity |
| MF | TAS | GO:0003714 | transcription corepressor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0008134 | transcription factor binding |
| MF | TAS | GO:0008270 | zinc ion binding |
| MF | ISS | GO:0070888 | E-box binding |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IEA | GO:0005667 | transcription factor complex |
| CC | IDA | GO:0005829 | cytosol |
| BP | IDA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | TAS | GO:0006357 | regulation of transcription by RNA polymerase II |
| BP | TAS | GO:0006955 | immune response |
| BP | IEA | GO:0007389 | pattern specification process |
| BP | IEA | GO:0007417 | central nervous system development |
| BP | TAS | GO:0008283 | cell proliferation |
| BP | IEA | GO:0008285 | negative regulation of cell proliferation |
| BP | IEA | GO:0010464 | regulation of mesenchymal cell proliferation |
| BP | IEA | GO:0017015 | regulation of transforming growth factor beta receptor signaling pathway |
| BP | TAS | GO:0019221 | cytokine-mediated signaling pathway |
| BP | IEA | GO:0033081 | regulation of T cell differentiation in thymus |
| BP | IMP | GO:0045602 | negative regulation of endothelial cell differentiation |
| BP | ISS | GO:0045666 | positive regulation of neuron differentiation |
| BP | IDA | GO:0045892 | negative regulation of transcription, DNA-templated |
| BP | IMP | GO:0045892 | negative regulation of transcription, DNA-templated |
| BP | IEA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0048596 | embryonic camera-type eye morphogenesis |
| BP | IEA | GO:0048704 | embryonic skeletal system morphogenesis |
| BP | IEA | GO:0048752 | semicircular canal morphogenesis |
| BP | IEA | GO:0051150 | regulation of smooth muscle cell differentiation |
| BP | IEA | GO:0051216 | cartilage development |
| BP | IEA | GO:0071230 | cellular response to amino acid stimulus |
| BP | IEA | GO:0090103 | cochlea morphogenesis |
Gene expression in normal tissue: ZEB1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ZEB1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | ilk_pathway | Integrin-linked kinase signaling |
| netpath | Pathway_TGF_beta_Receptor | TGF_beta_Receptor |
| pharmgkb | PA165984799 | Diuretics Pathway, Pharmacodynamics |
| kegg | hsa05202 | Transcriptional misregulation in cancer - Homo sapiens (human) |
| kegg | hsa05206 | MicroRNAs in cancer - Homo sapiens (human) |
| kegg | hsa05215 | Prostate cancer - Homo sapiens (human) |
| wikipathways | WP2003 | miR-targeted genes in leukocytes - TarBase |
| wikipathways | WP2004 | miR-targeted genes in lymphocytes - TarBase |
| wikipathways | WP2005 | miR-targeted genes in muscle cell - TarBase |
| wikipathways | WP2943 | Hypoxia-mediated EMT and Stemness |
| wikipathways | WP366 | TGF-beta Signaling Pathway |
| wikipathways | WP4018 | Pathways in clear cell renal cell carcinoma |
| wikipathways | WP4066 | Interleukin-4 and 13 signaling |
| wikipathways | WP4239 | EMT transition in Colorectal Cancer |
| wikipathways | WP516 | Hypertrophy Model |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling |
| biocarta | ctbp1pathway | sumoylation as a mechanism to modulate ctbp-dependent gene responses |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD66 | Doxorubicin | 2 |
| iGMDRD529 | Salinomycin | 1 |
| iGMDRD79 | Gemcitabine | 1 |
| iGMDRD50 | Cytarabine | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ZEB1
CLASSFICATION
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