ZFP36L1


Summary: This gene is a member of the TIS11 family of early response genes, which are induced by various agonists such as the phorbol ester TPA and the polypeptide mitogen EGF. This gene is well conserved across species and has a promoter that contains motifs seen in other early-response genes. The encoded protein contains a distinguishing putative zinc finger domain with a repeating cys-his motif. This putative nuclear transcription factor most likely functions in regulating the response to growth factors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
ZFP36 ring finger protein like 1MIM:601064Ensembl:ENSG00000185650HGNC:HGNC:1107PA3502714q24.1

Gene Categories:

TUMOR SUPPRESSOR

GO terms in ZFP36L1


Term TypeEvidence TypeGO Term IDGO Des.
BPIDAGO:0000165MAPK cascade
BPIEAGO:0000288nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
BPIEAGO:0001570vasculogenesis
BPIEAGO:0003342proepicardium development
BPIEAGO:0006357regulation of transcription by RNA polymerase II
BPIEAGO:0006397mRNA processing
BPIEAGO:0006915apoptotic process
BPIEAGO:0007507heart development
BPIEAGO:0008283cell proliferation
BPIDAGO:0009611response to wounding
BPIDAGO:0010468regulation of gene expression
BPIMPGO:0010837regulation of keratinocyte proliferation
BPIDAGO:0014065phosphatidylinositol 3-kinase signaling
BPIEAGO:0021915neural tube development
BPISSGO:0031086nuclear-transcribed mRNA catabolic process, deadenylation-independent decay
BPIDAGO:0031440regulation of mRNA 3'-end processing
BPIDAGO:0032869cellular response to insulin stimulus
BPISSGO:0033077T cell differentiation in thymus
BPIEAGO:0035264multicellular organism growth
BPISSGO:0038066p38MAPK cascade
BPIDAGO:0043488regulation of mRNA stability
BPIMPGO:0043488regulation of mRNA stability
BPTASGO:0043488regulation of mRNA stability
BPISSGO:0043491protein kinase B signaling
BPISSGO:0044344cellular response to fibroblast growth factor stimulus
BPISSGO:0045577regulation of B cell differentiation
BPISSGO:0045600positive regulation of fat cell differentiation
BPIMPGO:0045616regulation of keratinocyte differentiation
BPIDAGO:0045647negative regulation of erythrocyte differentiation
BPIDAGO:0045657positive regulation of monocyte differentiation
BPISSGO:0045661regulation of myoblast differentiation
BPISSGO:0048382mesendoderm development
BPIMPGO:0051028mRNA transport
BPIEAGO:0060710chorio-allantoic fusion
BPIEAGO:0060712spongiotrophoblast layer development
BPIBAGO:00611583'-UTR-mediated mRNA destabilization
BPIDAGO:00611583'-UTR-mediated mRNA destabilization
BPIMPGO:00611583'-UTR-mediated mRNA destabilization
BPIDAGO:0070371ERK1 and ERK2 cascade
BPIDAGO:0071320cellular response to cAMP
BPIDAGO:0071356cellular response to tumor necrosis factor
BPIDAGO:0071364cellular response to epidermal growth factor stimulus
BPIDAGO:0071375cellular response to peptide hormone stimulus
BPIDAGO:0071385cellular response to glucocorticoid stimulus
BPIMPGO:0071456cellular response to hypoxia
BPISSGO:0071472cellular response to salt stress
BPIDAGO:0071560cellular response to transforming growth factor beta stimulus
BPISSGO:0072091regulation of stem cell proliferation
BPISSGO:0097403cellular response to raffinose
BPISSGO:1900153positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
BPISSGO:1901991negative regulation of mitotic cell cycle phase transition
BPIMPGO:1902172regulation of keratinocyte apoptotic process
BPIMPGO:1904582positive regulation of intracellular mRNA localization
CCIDAGO:0000932P-body
CCIDAGO:0005634nucleus
CCIDAGO:0005737cytoplasm
CCIBAGO:0005829cytosol
CCTASGO:0005829cytosol
CCIDAGO:1990904ribonucleoprotein complex
MFISMGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFIEAGO:0003677DNA binding
MFNASGO:0003700DNA-binding transcription factor activity
MFHDAGO:0003723RNA binding
MFIDAGO:0003729mRNA binding
MFIBAGO:0003730mRNA 3'-UTR binding
MFIPIGO:0005515protein binding
MFIDAGO:0035925mRNA 3'-UTR AU-rich region binding
MFIEAGO:0046872metal ion binding
MFIDAGO:007188914-3-3 protein binding

Gene expression in normal tissue: ZFP36L1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ZFP36L1


DatabasePathway IDPathway Des.
pidmyc_represspathwayValidated targets of C-MYC transcriptional repression
kegghsa04218Cellular senescence - Homo sapiens (human)
reactomeR-HSA-450385Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
reactomeR-HSA-450531Regulation of mRNA stability by proteins that bind AU-rich elements
reactomeR-HSA-8953854Metabolism of RNA

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD1019TL-2-1051

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ZFP36L1

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