ZMIZ2
Summary: ZMIZ2 and ZMIZ1 (MIM 607159) are members of a PIAS (see MIM 603566)-like family of proteins that interact with nuclear hormone receptors. ZMIZ2 interacts with androgen receptor (AR; MIM 313700) and enhances AR-mediated transcription (Huang et al., 2005 [PubMed 16051670]).[supplied by OMIM, May 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| zinc finger MIZ-type containing 2 | MIM:611196 | Ensembl:ENSG00000122515 | HGNC:HGNC:22229 | PA162409851 | 7p13 |
GO terms in ZMIZ2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0008270 | zinc ion binding |
| MF | IDA | GO:0030374 | nuclear receptor transcription coactivator activity |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | IDA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005739 | mitochondrion |
| CC | IDA | GO:0043596 | nuclear replication fork |
Gene expression in normal tissue: ZMIZ2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ZMIZ2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | ar_tf_pathway | Regulation of Androgen receptor activity |
| netpath | Pathway_AndrogenReceptor | AndrogenReceptor |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ZMIZ2
CLASSFICATION
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