ZNF423
Summary: The protein encoded by this gene is a nuclear protein that belongs to the family of Kruppel-like C2H2 zinc finger proteins. It functions as a DNA-binding transcription factor by using distinct zinc fingers in different signaling pathways. Thus, it is thought that this gene may have multiple roles in signal transduction during development. Mutations in this gene are associated with nephronophthisis-14 and Joubert syndrome-19. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2012].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| zinc finger protein 423 | MIM:604557 | Ensembl:ENSG00000102935 | HGNC:HGNC:16762 | PA134903681 | 16q12.1 |
GO terms in ZNF423
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | IBA | GO:0006355 | regulation of transcription, DNA-templated |
| BP | ISS | GO:0007219 | Notch signaling pathway |
| BP | IEA | GO:0007399 | nervous system development |
| BP | IEA | GO:0030154 | cell differentiation |
| BP | ISS | GO:0030513 | positive regulation of BMP signaling pathway |
| BP | IDA | GO:0045892 | negative regulation of transcription, DNA-templated |
| BP | IDA | GO:0045893 | positive regulation of transcription, DNA-templated |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IBA | GO:0003677 | DNA binding |
| MF | IEA | GO:0003677 | DNA binding |
| MF | IBA | GO:0003700 | DNA-binding transcription factor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0046872 | metal ion binding |
Gene expression in normal tissue: ZNF423
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ZNF423
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2895 | Differentiation of white and brown adipocyte |
| wikipathways | WP3946 | White fat cell differentiation |
| wikipathways | WP4149 | White fat cell differentiation |
| wikipathways | WP560 | TGF-beta Receptor Signaling |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD294 | Batimastat | 4 |
| iGMDRD77 | Itraconazole | 3 |
| iGMDRD187 | BRD9876 | 3 |
| iGMDRD226 | ML006 | 5 |
| iGMDRD434 | BMS-536924 | 3 |
| iGMDRD782 | DC-45-A2 | 3 |
| iGMDRD192 | CIL56 | 1 |
| iGMDRD137 | Indisulam | 3 |
| iGMDRD451 | Serdemetan | 3 |
| iGMDRD524 | ISX-9 | 4 |
| iGMDRD353 | PD0325901 | 1 |
| iGMDRD60 | Quinoclamine | 6 |
| iGMDRD780 | PP-30 | 3 |
| iGMDRD577 | BIX01294 | 3 |
| iGMDRD887 | Compound 23 citrate | 3 |
| iGMDRD414 | MST-312 | 3 |
| iGMDRD79 | Gemcitabine | 4 |
| iGMDRD494 | Neopeltolide | 3 |
| iGMDRD670 | ML 210 | 3 |
| iGMDRD144 | NSC95397 | 2 |
| iGMDRD560 | MK-2206 | 2 |
| iGMDRD772 | BRD4770 | 2 |
| iGMDRD889 | Compound 7d-cis | 3 |
| iGMDRD486 | Tosedostat | 1 |
| iGMDRD76 | Simvastatin | 3 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
| iGMDRD61 | Kinetin riboside | 1 |
| iGMDRD57 | Chloropentafluorobenzene | 6 |
| iGMDRD85 | Ursolic acid | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ZNF423
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