Summary: This gene encodes a member of the Kruppel-like zinc finger family of proteins. Amplification and overexpression of this gene have been observed in esophageal squamous cell carcinoma. The encoded protein has been shown to bind DNA in a sequence-specific manner and may regulate HIV-1 gene expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014].

zinc finger protein 639Ensembl:ENSG00000121864HGNC:HGNC:30950PA1349907963q26.33

GO terms in ZNF639

Term TypeEvidence TypeGO Term IDGO Des.
BPIEAGO:0006366transcription by RNA polymerase II
BPIMPGO:0030307positive regulation of cell growth
BPIMPGO:0043922negative regulation by host of viral transcription
BPIMPGO:0043923positive regulation by host of viral transcription
BPIDAGO:0045892negative regulation of transcription, DNA-templated
BPIBAGO:0045944positive regulation of transcription by RNA polymerase II
BPIDAGO:0045944positive regulation of transcription by RNA polymerase II
BPIDAGO:0046718viral entry into host cell
MFIDAGO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding
MFISAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFIDAGO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
MFIBAGO:0003700DNA-binding transcription factor activity
MFIDAGO:0003700DNA-binding transcription factor activity
MFIPIGO:0005515protein binding
MFIPIGO:0043621protein self-association
MFIBAGO:0044212transcription regulatory region DNA binding
MFIDAGO:0044212transcription regulatory region DNA binding
MFIEAGO:0046872metal ion binding

Gene expression in normal tissue: ZNF639

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ZNF639

DatabasePathway IDPathway Des.

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ZNF639