ZNRD1
Summary: This gene encodes a DNA-directed RNA polymerase I subunit. The encoded protein contains two potential zinc-binding motifs and may play a role in regulation of cell proliferation. The encoded protein may be involved in cancer and human immunodeficiency virus progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| zinc ribbon domain containing 1 | MIM:607525 | Ensembl:ENSG00000066379 | HGNC:HGNC:13182 | PA37754 | 6p22.1 |
GO terms in ZNRD1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IBA | GO:0000428 | DNA-directed RNA polymerase complex |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005736 | DNA-directed RNA polymerase I complex |
| BP | TAS | GO:0006139 | nucleobase-containing compound metabolic process |
| BP | TAS | GO:0006361 | transcription initiation from RNA polymerase I promoter |
| BP | IBA | GO:0006363 | termination of RNA polymerase I transcription |
| BP | TAS | GO:0006363 | termination of RNA polymerase I transcription |
| BP | IEA | GO:0006379 | mRNA cleavage |
| BP | TAS | GO:0045815 | positive regulation of gene expression, epigenetic |
| MF | IBA | GO:0001054 | RNA polymerase I activity |
| MF | IEA | GO:0003676 | nucleic acid binding |
| MF | IBA | GO:0003899 | DNA-directed 5'-3' RNA polymerase activity |
| MF | IEA | GO:0008270 | zinc ion binding |
Gene expression in normal tissue: ZNRD1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ZNRD1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-212165 | Epigenetic regulation of gene expression |
| reactome | R-HSA-212165 | Epigenetic regulation of gene expression |
| reactome | R-HSA-427413 | NoRC negatively regulates rRNA expression |
| reactome | R-HSA-5250913 | Positive epigenetic regulation of rRNA expression |
| reactome | R-HSA-5250924 | B-WICH complex positively regulates rRNA expression |
| reactome | R-HSA-5250941 | Negative epigenetic regulation of rRNA expression |
| reactome | R-HSA-73762 | RNA Polymerase I Transcription Initiation |
| reactome | R-HSA-73762 | RNA Polymerase I Transcription Initiation |
| reactome | R-HSA-73772 | RNA Polymerase I Promoter Escape |
| reactome | R-HSA-73777 | RNA Polymerase I Chain Elongation |
| reactome | R-HSA-73854 | RNA Polymerase I Promoter Clearance |
| reactome | R-HSA-73854 | RNA Polymerase I Promoter Clearance |
| reactome | R-HSA-73863 | RNA Polymerase I Transcription Termination |
| reactome | R-HSA-73864 | RNA Polymerase I Transcription |
| reactome | R-HSA-73864 | RNA Polymerase I Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| wikipathways | WP4022 | Pyrimidine metabolism |
| kegg | hsa00230 | Purine metabolism - Homo sapiens (human) |
| kegg | hsa00240 | Pyrimidine metabolism - Homo sapiens (human) |
| kegg | hsa03020 | RNA polymerase - Homo sapiens (human) |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ZNRD1
CLASSFICATION
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