ZYX
Summary: Focal adhesions are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein complexes involved in signal transduction assemble. Zyxin is a zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin cytoskeleton. Zyxin has an N-terminal proline-rich domain and three LIM domains in its C-terminal half. The proline-rich domain may interact with SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein-protein binding. Zyxin may function as a messenger in the signal transduction pathway that mediates adhesion-stimulated changes in gene expression and may modulate the cytoskeletal organization of actin bundles. Alternative splicing results in multiple transcript variants that encode the same isoform. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| zyxin | MIM:602002 | Ensembl:ENSG00000159840 | HGNC:HGNC:13200 | PA37765 | 7q34 |
GO terms in ZYX
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | HDA | GO:0003723 | RNA binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0046872 | metal ion binding |
| CC | IDA | GO:0001725 | stress fiber |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005829 | cytosol |
| CC | IDA | GO:0005913 | cell-cell adherens junction |
| CC | HDA | GO:0005925 | focal adhesion |
| CC | IDA | GO:0005925 | focal adhesion |
| CC | IEA | GO:0045335 | phagocytic vesicle |
| BP | IC | GO:0007160 | cell-matrix adhesion |
| BP | IMP | GO:0007179 | transforming growth factor beta receptor signaling pathway |
| BP | IMP | GO:0007229 | integrin-mediated signaling pathway |
| BP | TAS | GO:0007267 | cell-cell signaling |
| BP | IEA | GO:0016032 | viral process |
| BP | IMP | GO:0043149 | stress fiber assembly |
| BP | IEA | GO:0050727 | regulation of inflammatory response |
| BP | IEA | GO:0071346 | cellular response to interferon-gamma |
Gene expression in normal tissue: ZYX
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ZYX
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP185 | Integrin-mediated Cell Adhesion |
| wikipathways | WP306 | Focal Adhesion |
| pid | ecadherin_keratinocyte_pathway | E-cadherin signaling in keratinocytes |
| pid | ecadherin_stabilization_pathway | Stabilization and expansion of the E-cadherin adherens junction |
| pid | ilk_pathway | Integrin-linked kinase signaling |
| pid | thrombin_par1_pathway | PAR1-mediated thrombin signaling events |
| kegg | hsa04510 | Focal adhesion - Homo sapiens (human) |
| biocarta | ecmpathway | erk and pi-3 kinase are necessary for collagen binding in corneal epithelia |
| biocarta | integrinpathway | integrin signaling pathway |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ZYX
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