ZYX


Summary: Focal adhesions are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein complexes involved in signal transduction assemble. Zyxin is a zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin cytoskeleton. Zyxin has an N-terminal proline-rich domain and three LIM domains in its C-terminal half. The proline-rich domain may interact with SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein-protein binding. Zyxin may function as a messenger in the signal transduction pathway that mediates adhesion-stimulated changes in gene expression and may modulate the cytoskeletal organization of actin bundles. Alternative splicing results in multiple transcript variants that encode the same isoform. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
zyxinMIM:602002Ensembl:ENSG00000159840HGNC:HGNC:13200PA377657q34

GO terms in ZYX


Term TypeEvidence TypeGO Term IDGO Des.
MFHDAGO:0003723RNA binding
MFIPIGO:0005515protein binding
MFIEAGO:0046872metal ion binding
CCIDAGO:0001725stress fiber
CCIDAGO:0005634nucleus
CCIDAGO:0005829cytosol
CCIDAGO:0005913cell-cell adherens junction
CCHDAGO:0005925focal adhesion
CCIDAGO:0005925focal adhesion
CCIEAGO:0045335phagocytic vesicle
BPICGO:0007160cell-matrix adhesion
BPIMPGO:0007179transforming growth factor beta receptor signaling pathway
BPIMPGO:0007229integrin-mediated signaling pathway
BPTASGO:0007267cell-cell signaling
BPIEAGO:0016032viral process
BPIMPGO:0043149stress fiber assembly
BPIEAGO:0050727regulation of inflammatory response
BPIEAGO:0071346cellular response to interferon-gamma

Gene expression in normal tissue: ZYX

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ZYX


DatabasePathway IDPathway Des.
wikipathwaysWP185Integrin-mediated Cell Adhesion
wikipathwaysWP306Focal Adhesion
pidecadherin_keratinocyte_pathwayE-cadherin signaling in keratinocytes
pidecadherin_stabilization_pathwayStabilization and expansion of the E-cadherin adherens junction
pidilk_pathwayIntegrin-linked kinase signaling
pidthrombin_par1_pathwayPAR1-mediated thrombin signaling events
kegghsa04510Focal adhesion - Homo sapiens (human)
biocartaecmpathwayerk and pi-3 kinase are necessary for collagen binding in corneal epithelia
biocartaintegrinpathwayintegrin signaling pathway

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259012

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ZYX

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