iGMDRD91

Canonical SMILES: CC(C)C(CCCN(C)CCC1=CC(=C(C=C1)OC)OC)(C#N)C2=CC(=C(C=C2)OC)OC

InChI: InChI=1S/C27H38N2O4/c1-20(2)27(19-28,22-10-12-24(31-5)26(18-22)33-7)14-8-15-29(3)16-13-21-9-11-23(30-4)25(17-21)32-6/h9-12,17-18,20H,8,13-16H2,1-7H3/t27-/m1/s1

InChI Key: SGTNSNPWRIOYBX-HHHXNRCGSA-N

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Standard Name
CHEMBL
Pubchem CID
Drug Status
Drug Type
Standard Name(R)-Verapamil
CHEMBLCHEMBL570489 CHEMBL1994739 CHEMBL197
Pubchem CID65808
Drug StatusAlone
Drug TypeSmall Molecule

Drug-model tissue-cancer distribution: Bubble Plot

ADRENAL_GLANtissue: ADRENAL_GLAN cancer: ADRENAL_GLAND model num: 0ADRENAL_GLANDtissue: ADRENAL_GLAND cancer: Adrenocortical Adenoma (ACA) model num: 1

Drug-gene pathway enrichments

2wikipathways: Notch Signaling Pathway1smpdb: Carteolol Action Pathway1smpdb: Bopindolol Action Pathway1smpdb: Timolol Action Pathway1smpdb: Sotalol Action Pathway1smpdb: Isoprenaline Action Pathway1smpdb: Dobutamine Action Pathway1smpdb: Epinephrine Action Pathway1smpdb: Muscle/Heart Contraction1smpdb: Nitrendipine Action Pathway

Drug-gene GO enrichments

2BP: regulation of ion transmembrane transport2BP: potassium ion import2MF: inward rectifier potassium channel activity1BP: regulation of heart rate by cardiac conduction1BP: membrane repolarization during atrial cardiac muscle cell action potential1BP: potassium ion import across plasma membrane1BP: ventricular cardiac muscle cell membrane repolarization1BP: membrane repolarization during ventricular cardiac muscle cell action potential1BP: potassium ion transport1CC: T-tubule

Drug-Gene: Aster Plot


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Gene ID
Gene Name
Model Num.
3762 KCNJ5 1
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Gene in drug-gene network: Network Plot

AmilorideAmiloridePD0325901PD0325901KCNJ5KCNJ5(R)-Verapamil(R)-Verapamil

Models in (R)-Verapamil

Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
SNV(KCNJ5 L168R) gene 24506072 ADRENAL_GLAND Adrenocortical Adenoma (ACA) Verapamil sensitivity in vivo
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