Summary: This gene encodes an integral membrane protein which belongs to one of seven subfamilies of inward-rectifier potassium channel proteins called potassium channel subfamily J. The encoded protein is a subunit of the potassium channel which is homotetrameric. It is controlled by G-proteins and has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Naturally occurring mutations in this gene are associated with aldosterone-producing adenomas. [provided by RefSeq, Aug 2017].

potassium voltage-gated channel subfamily J member 5MIM:600734Ensembl:ENSG00000120457HGNC:HGNC:6266PA21611q24.3

GO terms in KCNJ5

Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0005242inward rectifier potassium channel activity
MFIDAGO:0005242inward rectifier potassium channel activity
MFIPIGO:0005515protein binding
MFTASGO:0015467G-protein activated inward rectifier potassium channel activity
MFIMPGO:0086089voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization
MFICGO:1902282voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
CCTASGO:0005886plasma membrane
CCIDAGO:0008076voltage-gated potassium channel complex
CCIEAGO:0009897external side of plasma membrane
BPTASGO:0006813potassium ion transport
BPIBAGO:0010107potassium ion import
BPIDAGO:0010107potassium ion import
BPIBAGO:0034765regulation of ion transmembrane transport
BPIEAGO:0034765regulation of ion transmembrane transport
BPIMPGO:0086091regulation of heart rate by cardiac conduction
BPIMPGO:0098914membrane repolarization during atrial cardiac muscle cell action potential
BPIEAGO:0098915membrane repolarization during ventricular cardiac muscle cell action potential
BPICGO:0099625ventricular cardiac muscle cell membrane repolarization
BPIDAGO:1990573potassium ion import across plasma membrane

Gene expression in normal tissue: KCNJ5

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in KCNJ5

DatabasePathway IDPathway Des.
reactomeR-HSA-112314Neurotransmitter receptors and postsynaptic signal transmission
reactomeR-HSA-112315Transmission across Chemical Synapses
reactomeR-HSA-112316Neuronal System
reactomeR-HSA-1296041Activation of G protein gated Potassium channels
reactomeR-HSA-1296059G protein gated Potassium channels
reactomeR-HSA-1296065Inwardly rectifying K+ channels
reactomeR-HSA-1296071Potassium Channels
reactomeR-HSA-977443GABA receptor activation
reactomeR-HSA-977444GABA B receptor activation
reactomeR-HSA-991365Activation of GABAB receptors
reactomeR-HSA-997272Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
smpdbSMP00296Acebutolol Action Pathway
smpdbSMP00297Alprenolol Action Pathway
smpdbSMP00298Atenolol Action Pathway
smpdbSMP00299Betaxolol Action Pathway
smpdbSMP00300Bisoprolol Action Pathway
smpdbSMP00301Esmolol Action Pathway
smpdbSMP00302Metoprolol Action Pathway
smpdbSMP00303Nadolol Action Pathway
smpdbSMP00304Oxprenolol Action Pathway
smpdbSMP00305Penbutolol Action Pathway
smpdbSMP00306Pindolol Action Pathway
smpdbSMP00307Propranolol Action Pathway
smpdbSMP00323Quinidine Action Pathway
smpdbSMP00324Procainamide (Antiarrhythmic) Action Pathway
smpdbSMP00325Disopyramide Action Pathway
smpdbSMP00326Fosphenytoin (Antiarrhythmic) Action Pathway
smpdbSMP00327Phenytoin (Antiarrhythmic) Action Pathway
smpdbSMP00328Lidocaine (Antiarrhythmic) Action Pathway
smpdbSMP00329Mexiletine Action Pathway
smpdbSMP00330Tocainide Action Pathway
smpdbSMP00331Flecainide Action Pathway
smpdbSMP00332Ibutilide Action Pathway
smpdbSMP00359Diltiazem Action Pathway
smpdbSMP00366Nebivolol Action Pathway
smpdbSMP00367Carvedilol Action Pathway
smpdbSMP00368Labetalol Action Pathway
smpdbSMP00375Verapamil Action Pathway
smpdbSMP00376Amlodipine Action Pathway
smpdbSMP00377Felodipine Action Pathway
smpdbSMP00378Isradipine Action Pathway
smpdbSMP00379Nifedipine Action Pathway
smpdbSMP00380Nimodipine Action Pathway
smpdbSMP00381Nisoldipine Action Pathway
smpdbSMP00382Nitrendipine Action Pathway
smpdbSMP00588Muscle/Heart Contraction
smpdbSMP00657Bopindolol Action Pathway
smpdbSMP00658Carteolol Action Pathway
smpdbSMP00659Timolol Action Pathway
smpdbSMP00660Sotalol Action Pathway
smpdbSMP00661Epinephrine Action Pathway
smpdbSMP00662Dobutamine Action Pathway
smpdbSMP00663Isoprenaline Action Pathway
smpdbSMP00664Arbutamine Action Pathway
smpdbSMP00665Amiodarone Action Pathway
smpdbSMP00666Levobunolol Action Pathway
smpdbSMP00667Metipranolol Action Pathway
smpdbSMP00668Bevantolol Action Pathway
smpdbSMP00669Practolol Action Pathway
smpdbSMP00670Bupranolol Action Pathway
wikipathwaysWP268Notch Signaling Pathway
wikipathwaysWP4242Notch Signaling Pathway
wikipathwaysWP536Calcium Regulation in the Cardiac Cell
kegghsa04713Circadian entrainment - Homo sapiens (human)
kegghsa04723Retrograde endocannabinoid signaling - Homo sapiens (human)
kegghsa04726Serotonergic synapse - Homo sapiens (human)
kegghsa04728Dopaminergic synapse - Homo sapiens (human)
kegghsa04915Estrogen signaling pathway - Homo sapiens (human)
kegghsa04921Oxytocin signaling pathway - Homo sapiens (human)
kegghsa04925Aldosterone synthesis and secretion - Homo sapiens (human)
kegghsa05032Morphine addiction - Homo sapiens (human)
pharmgkbPA2033Antiarrhythmic Pathway, Pharmacodynamics

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in KCNJ5