KCNJ5

Summary: This gene encodes an integral membrane protein which belongs to one of seven subfamilies of inward-rectifier potassium channel proteins called potassium channel subfamily J. The encoded protein is a subunit of the potassium channel which is homotetrameric. It is controlled by G-proteins and has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Naturally occurring mutations in this gene are associated with aldosterone-producing adenomas. [provided by RefSeq, Aug 2017].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namepotassium voltage-gated channel subfamily J member 5
OMIM IDMIM:600734
Ensembl IDEnsembl:ENSG00000120457
HGNC IDHGNC:HGNC:6266
PHARMGKB IDPA216
Map Location11q24.3

GO terms in KCNJ5


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IBA GO:0005242 inward rectifier potassium channel activity
MF IDA GO:0005242 inward rectifier potassium channel activity
MF IPI GO:0005515 protein binding
MF TAS GO:0015467 G-protein activated inward rectifier potassium channel activity
MF IMP GO:0086089 voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization
MF IC GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
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Gene expression in normal tissue: KCNJ5

Gene-model tissue-cancer distribution: Bubble Plot

ADRENAL_GLANtissue: ADRENAL_GLAN cancer: ADRENAL_GLAND model num: 0ADRENAL_GLANDtissue: ADRENAL_GLAND cancer: Adrenocortical Adenoma (ACA) model num: 2undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 1

Gene-drug pathway distribution

ERK MAPK signaling1Aldosterone-regulated sodium reabsorption1undefined1

Pathways in KCNJ5


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Database
Pathway ID
Pathway Des.
reactome R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission
reactome R-HSA-112315 Transmission across Chemical Synapses
reactome R-HSA-112316 Neuronal System
reactome R-HSA-1296041 Activation of G protein gated Potassium channels
reactome R-HSA-1296059 G protein gated Potassium channels
reactome R-HSA-1296065 Inwardly rectifying K+ channels
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD91 (R)-Verapamil 1
iGMDRD59 Amiloride 1
iGMDRD353 PD0325901 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in KCNJ5

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
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