iGMDRD59

Canonical SMILES: C1(=C(N=C(C(=N1)Cl)N)N)C(=O)N=C(N)N

InChI: InChI=1S/C6H8ClN7O/c7-2-4(9)13-3(8)1(12-2)5(15)14-6(10)11/h(H4,8,9,13)(H4,10,11,14,15)

InChI Key: XSDQTOBWRPYKKA-UHFFFAOYSA-N

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Standard Name
CHEMBL
Pubchem CID
KEGG Drug ID
DRUGBANK ID
Drug Status
Drug targets (TTD)
Drug Type
Standard NameAmiloride
CHEMBLCHEMBL945 CHEMBL540851 CHEMBL1201085 CHEMBL1398126
Pubchem CID16231
KEGG Drug IDD07447
DRUGBANK IDDB00594
Drug StatusAlone
Drug targets (TTD)DAP000187
Drug TypeSmall Molecule




Drug-model tissue-cancer distribution: Bubble Plot

ADRENAL_GLANtissue: ADRENAL_GLAN cancer: ADRENAL_GLAND model num: 0ADRENAL_GLANDtissue: ADRENAL_GLAND cancer: Adrenocortical Adenoma (ACA) model num: 1

Drug-gene pathway enrichments

2wikipathways: Notch Signaling Pathway1smpdb: Carteolol Action Pathway1smpdb: Bopindolol Action Pathway1smpdb: Timolol Action Pathway1smpdb: Sotalol Action Pathway1smpdb: Isoprenaline Action Pathway1smpdb: Dobutamine Action Pathway1smpdb: Epinephrine Action Pathway1smpdb: Muscle/Heart Contraction1smpdb: Nitrendipine Action Pathway

Drug-gene GO enrichments

2BP: regulation of ion transmembrane transport2BP: potassium ion import2MF: inward rectifier potassium channel activity1BP: regulation of heart rate by cardiac conduction1BP: membrane repolarization during atrial cardiac muscle cell action potential1BP: potassium ion import across plasma membrane1BP: ventricular cardiac muscle cell membrane repolarization1BP: membrane repolarization during ventricular cardiac muscle cell action potential1BP: potassium ion transport1CC: T-tubule

Drug-Gene: Aster Plot


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Gene ID
Gene Name
Model Num.
3762 KCNJ5 1
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Gene in drug-gene network: Network Plot

PD0325901PD0325901(R)-Verapamil(R)-VerapamilKCNJ5KCNJ5AmilorideAmiloride

Models in Amiloride

Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
SNV(KCNJ5 L168R) gene 24506072 ADRENAL_GLAND Adrenocortical Adenoma (ACA) Amiloride sensitivity in vivo
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