iGMDRD1033

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Standard Name
Drug Status
Drug Type
Standard NameWEE1 inhibitor
Drug StatusFamily
Drug TypeSmall Molecule


Drug Targets:

WEE1CHEK1

Drug Pathways:

Cell cycle

Drug-model tissue-cancer distribution: Bubble Plot

OTHEtissue: OTHE cancer: OTHER model num: 0OTHERtissue: OTHER cancer: Cancer of Unknown Primary (CUP) model num: 5HEAD_NECtissue: HEAD_NEC cancer: HEAD_NECK model num: 0HEAD_NECKtissue: HEAD_NECK cancer: Head and Neck Carcinoma model num: 1HEAD_NECKtissue: HEAD_NECK cancer: Head and Neck Carcinoma, Other (OHNCA) model num: 1OVARtissue: OVAR cancer: OVARY model num: 0OVARYtissue: OVARY cancer: Ovarian Cancer model num: 1

Drug-gene pathway enrichments

3reactome: Cell Cycle3reactome: Metabolism of proteins3wikipathways: Pathways Affected in Adenoid Cystic Carcinoma2reactome: RNA Polymerase II Transcription2reactome: Gene expression (Transcription)2reactome: DNA Repair2reactome: Cell Cycle Checkpoints2reactome: G2/M Checkpoints2kegg: PI3K-Akt signaling pathway - Homo sapiens (human)2reactome: G2/M DNA damage checkpoint

Drug-gene GO enrichments

6BP: positive regulation of transcription by RNA polymerase II5BP: positive regulation of transcription, DNA-templated4CC: nucleus4BP: positive regulation of gene expression4MF: RNA polymerase II transcription factor activity, sequence-specific DNA binding4BP: positive regulation of cell cycle arrest4BP: negative regulation of transcription, DNA-templated4CC: nucleoplasm3BP: negative regulation of cell proliferation3MF: DNA binding

Drug-Gene: Aster Plot


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Gene ID
Gene Name
Model Num.
7157 TP53 3
29072 SETD2 3
672 BRCA1 2
Showing 1 to 3 of 3 rows

Gene in drug-gene network: Network Plot

Models in WEE1 inhibitor

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
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