TP53
Summary: This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). [provided by RefSeq, Dec 2016].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:191170 Ensembl IDEnsembl:ENSG00000141510 HGNC IDHGNC:HGNC:11998 PHARMGKB IDPA36679 Map Location17p13.1 | |||||
GO terms in TP53
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | ISS | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IDA | GO:0000733 | DNA strand renaturation |
| BP | TAS | GO:0006284 | base-excision repair |
| BP | IMP | GO:0006289 | nucleotide-excision repair |
| BP | IDA | GO:0006355 | regulation of transcription, DNA-templated |
| BP | IMP | GO:0006355 | regulation of transcription, DNA-templated |
Gene expression in normal tissue: TP53
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TP53
Database | Pathway ID | Pathway Des. |
|---|---|---|
| pharmgkb | PA165291507 | Fluoropyrimidine Pathway, Pharmacodynamics |
| pharmgkb | PA165292163 | Doxorubicin Pathway (Cancer Cell), Pharmacodynamics |
| pid | ap1_pathway | AP-1 transcription factor network |
| pid | aurora_a_pathway | Aurora A signaling |
| pid | bard1pathway | BARD1 signaling events |
| pid | hdac_classiii_pathway | Signaling events mediated by HDAC Class III |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TP53
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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