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iGMDRD552

Canonical SMILES: CC(C)(C1=NC(=CC=C1)N2C3=NC(=NC=C3C(=O)N2CC=C)NC4=CC=C(C=C4)N5CCN(CC5)C)O

InChI: InChI=1S/C27H32N8O2/c1-5-13-34-25(36)21-18-28-26(29-19-9-11-20(12-10-19)33-16-14-32(4)15-17-33)31-24(21)35(34)23-8-6-7-22(30-23)27(2,3)37/h5-12,18,37H,1,13-17H2,2-4H3,(H,28,29,31)

InChI Key: BKWJAKQVGHWELA-UHFFFAOYSA-N

Standard Name	CHEMBL	Pubchem CID	DRUGBANK ID	Drug Status	Drug Type
AZD-1775	CHEMBL1976040	24856400	DB11740	Alone	Small Molecule

Drug Class:

Azoles Heterocyclic Compounds Heterocyclic Compounds, 1-Ring

Drug Targets:

WEE1 (P30291)

Drug-model tissue-cancer distribution: Bubble Plot

Drug-gene pathway enrichments

Drug-gene GO enrichments

Drug-Gene: Aster Plot

Gene ID	Gene Name	Model Num.
4854	NOTCH3	2
7514	XPO1	2
8999	CDKL2	1
7074	TIAM1	4
79848	CSPP1	1
7837	PXDN	6
7128	TNFAIP3	2
6774	STAT3	3
2956	MSH6	1
3708	ITPR1	3
7272	TTK	2
6351	CCL4	4
3939	LDHA	3
2335	FN1	3
4928	NUP98	3
53616	ADAM22	3
9475	ROCK2	3
150209	AIFM3	1
81035	COLEC12	2
3326	HSP90AB1	2
4036	LRP2	1
7764	ZNF217	5
10395	DLC1	5
3069	HDLBP	3
390502	SERPINA2	2
1607	DGKB	3
10142	AKAP9	2
5298	PI4KB	1
140469	MYO3B	3
54822	TRPM7	6
1387	CREBBP	3
10454	TAB1	3
23225	NUP210	5
31	ACACA	2
9048	ARTN	5
8295	TRRAP	3
2625	GATA3	1
10438	C1D	5
7373	COL14A1	6
139378	ADGRG4	3
7158	TP53BP1	2
2033	EP300	4
55728	N4BP2	3
54477	PLEKHA5	2
57670	KIAA1549	1
4301	AFDN	2
84033	OBSCN	1
342667	STAC2	6
8852	AKAP4	2
2242	FES	3
22984	PDCD11	2
80351	TNKS2	2
6091	ROBO1	1
83990	BRIP1	1
3688	ITGB1	4
2045	EPHA7	5
1277	COL1A1	3
65217	PCDH15	1
6709	SPTAN1	2
6793	STK10	1
6464	SHC1	2
2778	GNAS	3
80243	PREX2	3
28996	HIPK2	1
4087	SMAD2	1
2050	EPHB4	3
2272	FHIT	2
5834	PYGB	1
58508	KMT2C	5
7157	TP53	3
6092	ROBO2	4
8218	CLTCL1	2
3791	KDR	6
1019	CDK4	1
85481	PSKH2	3
5604	MAP2K1	6
55034	MOCOS	3
57188	ADAMTSL3	1
65125	WNK1	2
57591	MRTFA	3
7175	TPR	3
23269	MGA	3
7994	KAT6A	1
3643	INSR	3
7204	TRIO	3
5727	PTCH1	1
546	ATRX	3
7270	TTF1	1
9972	NUP153	2
5290	PIK3CA	2
4293	MAP3K9	1
253260	RICTOR	2
10565	ARFGEF1	2
675	BRCA2	2
11064	CNTRL	2
64750	SMURF2	5
5789	PTPRD	3
1459	CSNK2A2	4
3553	IL1B	5
7917	BAG6	2
93627	TBCK	3
7153	TOP2A	2
57082	KNL1	2
1213	CLTC	3
3485	IGFBP2	1
8924	HERC2	3
120892	LRRK2	2
89795	NAV3	3
146057	TTBK2	2
9321	TRIP11	2
9509	ADAMTS2	2
23742	NPAP1	3
57521	RPTOR	3
667	DST	4
5305	PIP4K2A	3
11315	PARK7	1
8522	GAS7	3
5582	PRKCG	5
6789	STK4	3
23332	CLASP1	3
55561	CDC42BPG	3
4297	KMT2A	2
7248	TSC1	1
2067	ERCC1	1
9223	MAGI1	1
9659	PDE4DIP	4
54101	RIPK4	3
2157	F8	2
5506	PPP1R3A	3
65267	WNK3	2
100862685	ERVK-19	1
51167	CYB5R4	3
2903	GRIN2A	2
5925	RB1	3
2065	ERBB3	2
8661	EIF3A	3
4302	MLLT6	1
4638	MYLK	3
3716	JAK1	2
11086	ADAM29	3
2261	FGFR3	3
23072	HECW1	1
55422	ZNF331	2
4763	NF1	1
4593	MUSK	3
4629	MYH11	6
81788	NUAK2	1
1499	CTNNB1	4
27151	CPAMD8	2
2892	GRIA3	4
4916	NTRK3	4
1795	DOCK3	2

Gene in drug-gene network: Network Plot

Models in AZD-1775

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DATATYPES

CLASSFICATION

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