INSR
Summary: This gene encodes a member of the receptor tyrosine kinase family of proteins. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form a heterotetrameric receptor. Binding of insulin or other ligands to this receptor activates the insulin signaling pathway, which regulates glucose uptake and release, as well as the synthesis and storage of carbohydrates, lipids and protein. Mutations in this gene underlie the inherited severe insulin resistance syndromes including type A insulin resistance syndrome, Donohue syndrome and Rabson-Mendenhall syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| insulin receptor | MIM:147670 | Ensembl:ENSG00000171105 | HGNC:HGNC:6091 | PA202 | 19p13.2 |
GO terms in INSR
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | ISS | GO:0005622 | intracellular |
| CC | IDA | GO:0005635 | nuclear envelope |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IC | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IBA | GO:0005887 | integral component of plasma membrane |
| CC | IDA | GO:0005887 | integral component of plasma membrane |
| CC | IBA | GO:0005899 | insulin receptor complex |
| CC | IMP | GO:0005899 | insulin receptor complex |
| CC | IDA | GO:0005901 | caveola |
| CC | ISS | GO:0009897 | external side of plasma membrane |
| CC | TAS | GO:0010008 | endosome membrane |
| CC | IDA | GO:0016020 | membrane |
| CC | IBA | GO:0030424 | axon |
| CC | IDA | GO:0031981 | nuclear lumen |
| CC | ISS | GO:0032590 | dendrite membrane |
| CC | ISS | GO:0032809 | neuronal cell body membrane |
| CC | IBA | GO:0043235 | receptor complex |
| CC | IDA | GO:0043235 | receptor complex |
| CC | HDA | GO:0070062 | extracellular exosome |
| BP | IMP | GO:0000187 | activation of MAPK activity |
| BP | IBA | GO:0001934 | positive regulation of protein phosphorylation |
| BP | IDA | GO:0001934 | positive regulation of protein phosphorylation |
| BP | IMP | GO:0003007 | heart morphogenesis |
| BP | IEA | GO:0005975 | carbohydrate metabolic process |
| BP | IMP | GO:0006355 | regulation of transcription, DNA-templated |
| BP | TAS | GO:0006468 | protein phosphorylation |
| BP | IDA | GO:0007186 | G-protein coupled receptor signaling pathway |
| BP | IBA | GO:0007275 | multicellular organism development |
| BP | TAS | GO:0007612 | learning |
| BP | TAS | GO:0007613 | memory |
| BP | IC | GO:0008284 | positive regulation of cell proliferation |
| BP | IDA | GO:0008284 | positive regulation of cell proliferation |
| BP | IMP | GO:0008284 | positive regulation of cell proliferation |
| BP | IDA | GO:0008286 | insulin receptor signaling pathway |
| BP | ISS | GO:0008286 | insulin receptor signaling pathway |
| BP | TAS | GO:0008286 | insulin receptor signaling pathway |
| BP | IEA | GO:0008544 | epidermis development |
| BP | IEA | GO:0008584 | male gonad development |
| BP | IBA | GO:0009968 | negative regulation of signal transduction |
| BP | IDA | GO:0018108 | peptidyl-tyrosine phosphorylation |
| BP | IMP | GO:0019087 | transformation of host cell by virus |
| BP | IBA | GO:0030154 | cell differentiation |
| BP | IEA | GO:0030238 | male sex determination |
| BP | IEA | GO:0030325 | adrenal gland development |
| BP | IMP | GO:0030335 | positive regulation of cell migration |
| BP | IEA | GO:0031017 | exocrine pancreas development |
| BP | IMP | GO:0032147 | activation of protein kinase activity |
| BP | IDA | GO:0032148 | activation of protein kinase B activity |
| BP | IDA | GO:0032869 | cellular response to insulin stimulus |
| BP | IBA | GO:0033674 | positive regulation of kinase activity |
| BP | IEA | GO:0038083 | peptidyl-tyrosine autophosphorylation |
| BP | IBA | GO:0042593 | glucose homeostasis |
| BP | IMP | GO:0042593 | glucose homeostasis |
| BP | IBA | GO:0043066 | negative regulation of apoptotic process |
| BP | ISS | GO:0043243 | positive regulation of protein complex disassembly |
| BP | IDA | GO:0043410 | positive regulation of MAPK cascade |
| BP | IMP | GO:0043410 | positive regulation of MAPK cascade |
| BP | IMP | GO:0045429 | positive regulation of nitric oxide biosynthetic process |
| BP | IDA | GO:0045725 | positive regulation of glycogen biosynthetic process |
| BP | IMP | GO:0045821 | positive regulation of glycolytic process |
| BP | IMP | GO:0045840 | positive regulation of mitotic nuclear division |
| BP | IEA | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | IMP | GO:0045995 | regulation of embryonic development |
| BP | IDA | GO:0046326 | positive regulation of glucose import |
| BP | NAS | GO:0046326 | positive regulation of glucose import |
| BP | IDA | GO:0046777 | protein autophosphorylation |
| BP | IMP | GO:0046777 | protein autophosphorylation |
| BP | IMP | GO:0048639 | positive regulation of developmental growth |
| BP | IDA | GO:0051290 | protein heterotetramerization |
| BP | IEA | GO:0051446 | positive regulation of meiotic cell cycle |
| BP | IMP | GO:0051897 | positive regulation of protein kinase B signaling |
| BP | IDA | GO:0060267 | positive regulation of respiratory burst |
| BP | IBA | GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| BP | IEA | GO:0071363 | cellular response to growth factor stimulus |
| BP | ISS | GO:0097062 | dendritic spine maintenance |
| BP | ISS | GO:0097242 | amyloid-beta clearance |
| BP | ISS | GO:1990535 | neuron projection maintenance |
| BP | IEA | GO:2000194 | regulation of female gonad development |
| MF | IPI | GO:0001540 | amyloid-beta binding |
| MF | IBA | GO:0004709 | MAP kinase kinase kinase activity |
| MF | IBA | GO:0004713 | protein tyrosine kinase activity |
| MF | IDA | GO:0004713 | protein tyrosine kinase activity |
| MF | IMP | GO:0004713 | protein tyrosine kinase activity |
| MF | IBA | GO:0004714 | transmembrane receptor protein tyrosine kinase activity |
| MF | IBA | GO:0004888 | transmembrane signaling receptor activity |
| MF | IBA | GO:0005009 | insulin-activated receptor activity |
| MF | IDA | GO:0005009 | insulin-activated receptor activity |
| MF | IDA | GO:0005159 | insulin-like growth factor receptor binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0005524 | ATP binding |
| MF | IDA | GO:0005525 | GTP binding |
| MF | IPI | GO:0019904 | protein domain specific binding |
| MF | IBA | GO:0031434 | mitogen-activated protein kinase kinase binding |
| MF | IPI | GO:0031994 | insulin-like growth factor I binding |
| MF | IPI | GO:0031995 | insulin-like growth factor II binding |
| MF | IPI | GO:0043548 | phosphatidylinositol 3-kinase binding |
| MF | IDA | GO:0043559 | insulin binding |
| MF | IPI | GO:0043559 | insulin binding |
| MF | IBA | GO:0043560 | insulin receptor substrate binding |
| MF | IPI | GO:0043560 | insulin receptor substrate binding |
| MF | IPI | GO:0044877 | protein-containing complex binding |
| MF | IPI | GO:0051425 | PTB domain binding |
Gene expression in normal tissue: INSR
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in INSR
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04014 | Ras signaling pathway - Homo sapiens (human) |
| kegg | hsa04015 | Rap1 signaling pathway - Homo sapiens (human) |
| kegg | hsa04022 | cGMP-PKG signaling pathway - Homo sapiens (human) |
| kegg | hsa04066 | HIF-1 signaling pathway - Homo sapiens (human) |
| kegg | hsa04068 | FoxO signaling pathway - Homo sapiens (human) |
| kegg | hsa04072 | Phospholipase D signaling pathway - Homo sapiens (human) |
| kegg | hsa04150 | mTOR signaling pathway - Homo sapiens (human) |
| kegg | hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| kegg | hsa04152 | AMPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04211 | Longevity regulating pathway - Homo sapiens (human) |
| kegg | hsa04213 | Longevity regulating pathway - multiple species - Homo sapiens (human) |
| kegg | hsa04520 | Adherens junction - Homo sapiens (human) |
| kegg | hsa04910 | Insulin signaling pathway - Homo sapiens (human) |
| kegg | hsa04913 | Ovarian steroidogenesis - Homo sapiens (human) |
| kegg | hsa04923 | Regulation of lipolysis in adipocytes - Homo sapiens (human) |
| kegg | hsa04930 | Type II diabetes mellitus - Homo sapiens (human) |
| kegg | hsa04931 | Insulin resistance - Homo sapiens (human) |
| kegg | hsa04932 | Non-alcoholic fatty liver disease (NAFLD) - Homo sapiens (human) |
| kegg | hsa04960 | Aldosterone-regulated sodium reabsorption - Homo sapiens (human) |
| netpath | Pathway_EGFR1 | EGFR1 |
| reactome | R-HSA-1257604 | PIP3 activates AKT signaling |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-199418 | Negative regulation of the PI3K/AKT network |
| reactome | R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling |
| reactome | R-HSA-74713 | IRS activation |
| reactome | R-HSA-74749 | Signal attenuation |
| reactome | R-HSA-74751 | Insulin receptor signalling cascade |
| reactome | R-HSA-74752 | Signaling by Insulin receptor |
| reactome | R-HSA-77387 | Insulin receptor recycling |
| reactome | R-HSA-9006925 | Intracellular signaling by second messengers |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| biocarta | ghpathway | growth hormone signaling pathway |
| biocarta | insulinpathway | insulin signaling pathway |
| pid | insulin_glucose_pathway | Insulin-mediated glucose transport |
| pid | insulin_pathway | Insulin Pathway |
| pid | ptp1bpathway | Signaling events mediated by PTP1B |
| pid | tcptp_pathway | Signaling events mediated by TCPTP |
| pharmgkb | PA153627758 | Anti-diabetic Drug Potassium Channel Inhibitors Pathway, Pharmacodynamics |
| smpdb | SMP00391 | Insulin Signalling |
| smpdb | SMP00682 | Leucine Stimulation on Insulin Signaling |
| wikipathways | WP1403 | AMP-activated Protein Kinase (AMPK) Signaling |
| wikipathways | WP15 | Selenium Micronutrient Network |
| wikipathways | WP1533 | Vitamin B12 Metabolism |
| wikipathways | WP1584 | Type II diabetes mellitus |
| wikipathways | WP176 | Folate Metabolism |
| wikipathways | WP2324 | AGE-RAGE pathway |
| wikipathways | WP2509 | Nanoparticle triggered autophagic cell death |
| wikipathways | WP3599 | Transcription factor regulation in adipogenesis |
| wikipathways | WP3915 | Angiopoietin Like Protein 8 Regulatory Pathway |
| wikipathways | WP3932 | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
| wikipathways | WP3935 | Leptin Insulin Overlap |
| wikipathways | WP4011 | Steatosis AOP |
| wikipathways | WP4172 | PI3K-Akt Signaling Pathway |
| wikipathways | WP4223 | Ras Signaling |
| wikipathways | WP481 | Insulin Signaling |
| wikipathways | WP710 | DNA Damage Response (only ATM dependent) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD202 | Curcumin | 3 |
| iGMDRD158 | NSC141540 | 6 |
| iGMDRD138 | PX 12 | 3 |
| iGMDRD255 | SB225002 | 3 |
| iGMDRD434 | BMS-536924 | 3 |
| iGMDRD289 | Parthenolide | 1 |
| iGMDRD105 | Triptolide | 2 |
| iGMDRD885 | Compound 110 | 3 |
| iGMDRD318 | PAC-1 | 3 |
| iGMDRD872 | BRD7137 | 3 |
| iGMDRD286 | Nsc 632839 | 3 |
| iGMDRD577 | BIX01294 | 1 |
| iGMDRD552 | AZD-1775 | 3 |
| iGMDRD246 | NPC26 | 3 |
| iGMDRD64 | Parbendazole | 3 |
| iGMDRD210 | AC55649 | 1 |
| iGMDRD151 | CHM-1 | 1 |
| iGMDRD84 | Lovastatin acid | 3 |
| iGMDRD420 | Leucascandrolide A | 3 |
| iGMDRD1008 | SR-II-138A | 3 |
| iGMDRD772 | BRD4770 | 3 |
| iGMDRD532 | Olaparib | 3 |
| iGMDRD483 | SCH-529074 | 3 |
| iGMDRD61 | Kinetin riboside | 1 |
| iGMDRD351 | GW843682X | 3 |
| iGMDRD177 | Teniposide | 3 |
| iGMDRD394 | BX-795 | 3 |
| iGMDRD945 | ML214 | 3 |
| iGMDRD435 | BI-2536 | 3 |
| iGMDRD634 | SCHEMBL2608041 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in INSR
CLASSFICATION
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