INSR

Summary: This gene encodes a member of the receptor tyrosine kinase family of proteins. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form a heterotetrameric receptor. Binding of insulin or other ligands to this receptor activates the insulin signaling pathway, which regulates glucose uptake and release, as well as the synthesis and storage of carbohydrates, lipids and protein. Mutations in this gene underlie the inherited severe insulin resistance syndromes including type A insulin resistance syndrome, Donohue syndrome and Rabson-Mendenhall syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Nameinsulin receptor
OMIM IDMIM:147670
Ensembl IDEnsembl:ENSG00000171105
HGNC IDHGNC:HGNC:6091
PHARMGKB IDPA202
Map Location19p13.2

GO terms in INSR


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Term Type
Evidence Type
GO Term ID
GO Des.
CC ISS GO:0005622 intracellular
CC IDA GO:0005635 nuclear envelope
CC IBA GO:0005737 cytoplasm
CC IC GO:0005886 plasma membrane
CC TAS GO:0005886 plasma membrane
CC IBA GO:0005887 integral component of plasma membrane
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Gene expression in normal tissue: INSR

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 38undefinedtissue: undefined cancer: SMALL_CELL_CARCINOMA model num: 3LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 15BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 8OVARtissue: OVAR cancer: OVARY model num: 0OVARYtissue: OVARY cancer: undefined model num: 10UTERUtissue: UTERU cancer: UTERUS model num: 0UTERUStissue: UTERUS cancer: Endometrial Carcinoma (UCEC) model num: 6

Gene-drug pathway distribution

undefined23Cell cycle2Genome integrity1Apoptosis regulation1Chromatin histone acetylation1DNA replication1Stilbenoid, diarylheptanoid and gingerol biosynthesis1

Pathways in INSR


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Database
Pathway ID
Pathway Des.
kegg hsa04010 MAPK signaling pathway - Homo sapiens (human)
kegg hsa04014 Ras signaling pathway - Homo sapiens (human)
kegg hsa04015 Rap1 signaling pathway - Homo sapiens (human)
kegg hsa04022 cGMP-PKG signaling pathway - Homo sapiens (human)
kegg hsa04066 HIF-1 signaling pathway - Homo sapiens (human)
kegg hsa04068 FoxO signaling pathway - Homo sapiens (human)
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD202 Curcumin 3
iGMDRD158 NSC141540 6
iGMDRD138 PX 12 3
iGMDRD255 SB225002 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in INSR

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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