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iGMDRD577

Canonical SMILES: CN1CCCN(CC1)C2=NC3=CC(=C(C=C3C(=N2)NC4CCN(CC4)CC5=CC=CC=C5)OC)OC

InChI: InChI=1S/C28H38N6O2/c1-32-12-7-13-34(17-16-32)28-30-24-19-26(36-3)25(35-2)18-23(24)27(31-28)29-22-10-14-33(15-11-22)20-21-8-5-4-6-9-21/h4-6,8-9,18-19,22H,7,10-17,20H2,1-3H3,(H,29,30,31)

InChI Key: OSXFATOLZGZLSK-UHFFFAOYSA-N

Standard Name	CHEMBL	Pubchem CID	Drug Status	Drug Type
BIX01294	CHEMBL569864	25150900	Alone	Small Molecule

Drug Targets:

EHMT2

Drug-model tissue-cancer distribution: Bubble Plot

Drug-gene pathway enrichments

Drug-gene GO enrichments

Drug-Gene: Aster Plot

Gene ID	Gene Name	Model Num.
331	XIAP	6
3696	ITGB8	1
27102	EIF2AK1	2
4854	NOTCH3	1
6664	SOX11	6
7074	TIAM1	2
5296	PIK3R2	3
81037	CLPTM1L	5
997	CDC34	3
79848	CSPP1	3
7535	ZAP70	2
7837	PXDN	3
10221	TRIB1	3
10641	NPRL2	1
23085	ERC1	3
6491	STIL	1
21	ABCA3	3
132	ADK	9
5933	RBL1	3
26191	PTPN22	4
4926	NUMA1	2
2986	GUCY2F	5
79947	DHDDS	3
4627	MYH9	4
2956	MSH6	1
2200	FBN1	1
55872	PBK	3
220064	LTO1	1
150465	TTL	3
3708	ITPR1	3
4477	MSMB	3
1520	CTSS	4
57554	LRRC7	4
9149	DYRK1B	3
7272	TTK	3
347365	ITIH6	2
3757	KCNH2	1
4750	NEK1	2
2100	ESR2	4
8289	ARID1A	2
3939	LDHA	2
51231	VRK3	3
51129	ANGPTL4	3
2335	FN1	5
84700	MYO18B	2
79092	CARD14	3
53616	ADAM22	3
4312	MMP1	6
9760	TOX	3
3431	SP110	2
9263	STK17A	1
6597	SMARCA4	5
5916	RARG	1
9869	SETDB1	2
7764	ZNF217	2
11160	ERLIN2	1
5241	PGR	3
11116	FGFR1OP	8
10320	IKZF1	5
3209	HOXA13	1
79820	CATSPERB	6
9530	BAG4	2
7444	VRK2	3
23495	TNFRSF13B	6
56776	FMN2	2
5079	PAX5	1
4313	MMP2	3
1786	DNMT1	3
6598	SMARCB1	2
4170	MCL1	5
1607	DGKB	4
3694	ITGB6	2
1272	CNTN1	2
9641	IKBKE	3
5218	CDK14	2
3066	HDAC2	5
7098	TLR3	4
6732	SRPK1	7
5298	PI4KB	2
8749	ADAM18	6
3841	KPNA5	4
2241	FER	7
1032	CDKN2D	3
28231	SLCO4A1	2
1387	CREBBP	6
1893	ECM1	4
26039	SS18L1	2
7555	CNBP	6
127933	UHMK1	2
5467	PPARD	10
56164	STK31	2
5579	PRKCB	6
11200	CHEK2	3
31	ACACA	3
7133	TNFRSF1B	3
9699	RIMS2	2
5596	MAPK4	1
8558	CDK10	3
29998	BICRA	7
26576	SRPK3	2
10438	C1D	3
23617	TSSK2	4
6722	SRF	3
9024	BRSK2	2
5396	PRRX1	3
5159	PDGFRB	8
55300	PI4K2B	2
7173	TPO	5
10215	OLIG2	6
4851	NOTCH1	3
5314	PKHD1	10
139378	ADGRG4	2
145264	SERPINA12	3
974	CD79B	3
6927	HNF1A	2
9578	CDC42BPB	3
641	BLM	2
83439	TCF7L1	4
1021	CDK6	6
1454	CSNK1E	3
23522	KAT6B	6
55728	N4BP2	2
1453	CSNK1D	7
57670	KIAA1549	3
837	CASP4	3
440279	UNC13C	5
4610	MYCL	7
3976	LIF	3
4301	AFDN	11
5081	PAX7	3
342667	STAC2	2
5607	MAP2K5	8
342977	NANOS3	6
2268	FGR	6
2118	ETV4	3
388228	SBK1	3
8767	RIPK2	6
1880	GPR183	4
2051	EPHB6	4
9693	RAPGEF2	3
23012	STK38L	3
1586	CYP17A1	2
6256	RXRA	4
1591	CYP24A1	2
3714	JAG2	3
32	ACACB	4
5613	PRKX	3
329	BIRC2	2
2688	GH1	6
6041	RNASEL	2
9175	MAP3K13	5
1437	CSF2	6
6733	SRPK2	5
1050	CEBPA	5
114548	NLRP3	2
80129	CCDC170	3
5984	RFC4	3
9636	ISG15	4
4216	MAP3K4	2
2736	GLI2	8
6198	RPS6KB1	1
1936	EEF1D	3
51804	SIX4	2
57761	TRIB3	1
9098	USP6	2
3303	HSPA1A	2
207	AKT1	1
7037	TFRC	3
4982	TNFRSF11B	2
23405	DICER1	3
7078	TIMP3	3
2064	ERBB2	2
6850	SYK	2
287015	TRIM42	1
3916	LAMP1	3
8395	PIP5K1B	5
6663	SOX10	3
834	CASP1	9
993	CDC25A	3
23191	CYFIP1	3
1456	CSNK1G3	7
6416	MAP2K4	5
9759	HDAC4	3
92	ACVR2A	4
7525	YES1	2
1452	CSNK1A1	3
57510	XPO5	6
65987	KCTD14	1
64170	CARD9	3
8215	DVL1P1	3
1973	EIF4A1	3
1909	EDNRA	1
158056	MAMDC4	2
10087	COL4A3BP	6
8859	STK19	3
6464	SHC1	5
6037	RNASE3	2
54437	SEMA5B	3
8515	ITGA10	9
3685	ITGAV	2
80243	PREX2	3
5229	PGGT1B	2
1009	CDH11	1
139285	AMER1	2
3397	ID1	3
2734	GLG1	2
4804	NGFR	3
8038	ADAM12	2
4058	LTK	5
55851	PSENEN	3
1123	CHN1	2
1496	CTNNA2	1
7010	TEK	1
7533	YWHAH	3
91461	PKDCC	3
23152	CIC	2
2050	EPHB4	2
2272	FHIT	9
7681	MKRN3	3
904	CCNT1	2
1647	GADD45A	2
5863	RGL2	5
10290	SPEG	2
10413	YAP1	9
10062	NR1H3	3
139728	PNCK	3
9361	LONP1	2
5129	CDK18	3
57523	NYNRIN	3
83694	RPS6KL1	6
10018	BCL2L11	2
8743	TNFSF10	2
7157	TP53	5
4602	MYB	3
6794	STK11	5
25836	NIPBL	2
8218	CLTCL1	6
57410	SCYL1	2
3791	KDR	3
2329	FMO4	6
6184	RPN1	3
2263	FGFR2	7
4086	SMAD1	1
130399	ACVR1C	6
8408	ULK1	2
5585	PKN1	3
7249	TSC2	2
1019	CDK4	3
7409	VAV1	2
65243	ZFP69B	6
9967	THRAP3	2
85481	PSKH2	3
5604	MAP2K1	3
4869	NPM1	3
863	CBFA2T3	6
8874	ARHGEF7	4
1555	CYP2B6	5
51086	TNNI3K	2
9088	PKMYT1	3
7422	VEGFA	3
7038	TG	2
4921	DDR2	3
3572	IL6ST	2
6197	RPS6KA3	5
57188	ADAMTSL3	1
65125	WNK1	1
57591	MRTFA	2
7495	XBP1P1	1
4436	MSH2	1
6535	SLC6A8	1
984	CDK11B	4
5650	KLK7	5
30012	TLX3	2
5871	MAP4K2	7
9401	RECQL4	1
3718	JAK3	6
23365	ARHGEF12	4
8831	SYNGAP1	3
84181	CHD6	2
8997	KALRN	5
4437	MSH3	2
23269	MGA	3
7994	KAT6A	1
3643	INSR	1
6280	S100A9	2
5371	PML	2
4089	SMAD4	3
54658	UGT1A1	1
6654	SOS1	2
672	BRCA1	3
2060	EPS15	5
1616	DAXX	2
11168	PSIP1	2
1848	DUSP6	8
4139	MARK1	3
7204	TRIO	6
78989	COLEC11	2
835	CASP2	1
23373	CRTC1	3
5727	PTCH1	6
285220	EPHA6	4
546	ATRX	7
3426	CFI	6
5606	MAP2K3	1
5297	PI4KA	2
2047	EPHB1	4
7786	MAP3K12	8
10926	DBF4	2
64840	PORCN	1
30827	CXXC1	6
56997	COQ8A	6
5578	PRKCA	5
286133	SCARA5	3
4214	MAP3K1	3
3702	ITK	5
3239	HOXD13	9
50615	IL21R	2
3562	IL3	9
92335	STRADA	2
3720	JARID2	2
4145	MATK	3
4293	MAP3K9	2
5366	PMAIP1	3
7043	TGFB3	3
85366	MYLK2	6
10565	ARFGEF1	2
64919	BCL11B	5
5530	PPP3CA	1
675	BRCA2	2
607	BCL9	4
4803	NGF	5
10155	TRIM28	3
7075	TIE1	3
1956	EGFR	9
157680	VPS13B	5
841	CASP8	3
2735	GLI1	3
3065	HDAC1	3
64333	ARHGAP9	3
64750	SMURF2	3
8021	NUP214	7
5155	PDGFB	3
10461	MERTK	3
51321	AMZ2	2
7297	TYK2	4
26278	SACS	4
894	CCND2	1
6776	STAT5A	8
51701	NLK	5
1594	CYP27B1	4
2189	FANCG	3
1653	DDX1	12
8900	CCNA1	7
7917	BAG6	2
375056	MIA3	2
10971	YWHAQ	3
1544	CYP1A2	6
91754	NEK9	6
93627	TBCK	7
137872	ADHFE1	4
7132	TNFRSF1A	3
56924	PAK6	2
673	BRAF	4
6011	GRK1	2
84879	MFSD2A	5
1769	DNAH8	3
5781	PTPN11	7
23532	PRAME	4
4863	NPAT	4
780	DDR1	3
57538	ALPK3	5
5598	MAPK7	3
8924	HERC2	2
6502	SKP2	3
120892	LRRK2	2
65268	WNK2	2
79184	BRCC3	4
6095	RORA	6
57507	ZNF608	2
84441	MAML2	3
5205	ATP8B1	3
7468	NSD2	6
8029	CUBN	2
11184	MAP4K1	3
460	ASTN1	1
9064	MAP3K6	2
5294	PIK3CG	6
4298	MLLT1	12
10253	SPRY2	6
9451	EIF2AK3	7
654780	LOC654780	3
1977	EIF4E	2
11262	SP140	2
51555	PEX5L	3
8491	MAP4K3	3
9509	ADAMTS2	2
3229	HOXC13	3
23396	PIP5K1C	1
10010	TANK	10
10752	CHL1	8
23476	BRD4	2
5728	PTEN	6
57521	RPTOR	5
208	AKT2	3
51592	TRIM33	4
7155	TOP2B	2
4914	NTRK1	3
22883	CLSTN1	2
667	DST	5
23281	MTUS2	3
115701	ALPK2	2
284086	NEK8	2
3554	IL1R1	7
53836	GPR87	5
1613	DAPK3	1
2897	GRIK1	5
140803	TRPM6	3
2188	FANCF	2
6146	RPL22	4
890	CCNA2	3
85409	NKD2	3
10962	MLLT11	2
6009	RHEB	6
1676	DFFA	3
2870	GRK6	3
9344	TAOK2	4
8301	PICALM	6
23090	ZNF423	3
28954	REM1	1
7273	TTN	6
1445	CSK	3
91807	MYLK3	5
79834	PEAK1	3
5582	PRKCG	5
6789	STK4	2
7454	WAS	1
7036	TFR2	6
85415	RHPN2	2
23389	MED13L	3
29959	NRBP1	4
54904	NSD3	4
23411	SIRT1	7
53904	MYO3A	1
387	RHOA	3
29941	PKN3	6
3161	HMMR	2
7150	TOP1	1
115650	TNFRSF13C	3
8394	PIP5K1A	6
3207	HOXA11	3
2353	FOS	4
23305	ACSL6	6
5291	PIK3CB	7
1493	CTLA4	2
558	AXL	2
7248	TSC1	6
126792	B3GALT6	2
4619	MYH1	4
2869	GRK5	1
5581	PRKCE	7
5923	RASGRF1	4
4774	NFIA	2
1399	CRKL	1
317	APAF1	3
9021	SOCS3	5
8031	NCOA4	1
10111	RAD50	5
100124696	TEC	4
6790	AURKA	4
9223	MAGI1	3
171389	NLRP6	2
7094	TLN1	3
152110	NEK10	3
1281	COL3A1	1
2185	PTK2B	1
63976	PRDM16	3
7293	TNFRSF4	6
54101	RIPK4	2
283455	KSR2	4
6093	ROCK1	2
3624	INHBA	5
2194	FASN	4
5927	KDM5A	2
598	BCL2L1	3
5583	PRKCH	3
5170	PDPK1	16
57448	BIRC6	2
5681	PSKH1	2
2304	FOXE1	3
23139	MAST2	7
7099	TLR4	4
2157	F8	1
7227	TRPS1	2
3709	ITPR2	2
1906	EDN1	3
8899	PRPF4B	3
4067	LYN	4
150094	SIK1	4
8428	STK24	5
4772	NFATC1	3
3516	RBPJ	3
7112	TMPO	3
3656	IRAK2	2
4330	MN1	2
84072	HORMAD1	7
1455	CSNK1G2	3
23512	SUZ12	6
11076	TPPP	1
7046	TGFBR1	4
3662	IRF4	2
51167	CYB5R4	6
1760	DMPK	2
5087	PBX1	1
9894	TELO2	3
6653	SORL1	3
2903	GRIN2A	4
5925	RB1	4
7113	TMPRSS2	3
63923	TNN	1
2065	ERBB3	2
3131	HLF	2
25	ABL1	2
862	RUNX1T1	1
3691	ITGB4	2
7403	KDM6A	4
2308	FOXO1	2
7508	XPC	4
4302	MLLT6	2
7040	TGFB1	8
3480	IGF1R	6
2011	MARK2	2
79728	PALB2	2
10494	STK25	3
11086	ADAM29	2
374	AREG	3
2261	FGFR3	3
5567	PRKACB	5
84197	POMK	2
8711	TNK1	2
84446	BRSK1	3
4841	NONO	3
156	GRK2	3
57697	FANCM	2
5260	PHKG1	2
1994	ELAVL1	7
4613	MYCN	4
1840	DTX1	4
65975	STK33	4
5288	PIK3C2G	4
57096	RPGRIP1	3
2280	FKBP1A	6
3110	MNX1	6
30811	HUNK	3
23683	PRKD3	2
6943	TCF21	6
1608	DGKG	5
2178	FANCE	7
1803	DPP4	1
83732	RIOK1	3
2444	FRK	4
27151	CPAMD8	2
5602	MAPK10	5
1436	CSF1R	2
1795	DOCK3	2
4486	MST1R	6
2904	GRIN2B	4
578	BAK1	3

Gene in drug-gene network: Network Plot

Models in BIX01294

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DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.