FMN2


Summary: This gene is a member of the formin homology protein family. The encoded protein is thought to have essential roles in organization of the actin cytoskeleton and in cell polarity. This protein mediates the formation of an actin mesh that positions the spindle during oogenesis and also regulates the formation of actin filaments in the nucleus. This protein also forms a perinuclear actin/focal-adhesion system that regulates the shape and position of the nucleus during cell migration. Mutations in this gene have been associated with infertility and also with an autosomal recessive form of intellectual disability (MRT47). Alternatively spliced transcript variants have been identified. [provided by RefSeq, Jul 2017].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
formin 2MIM:606373Ensembl:ENSG00000155816HGNC:HGNC:14074PA281851q43

GO terms in FMN2


Term TypeEvidence TypeGO Term IDGO Des.
MFNDGO:0003674molecular_function
MFIDAGO:0003779actin binding
CCIDAGO:0005730nucleolus
CCIEAGO:0005789endoplasmic reticulum membrane
CCIEAGO:0005819spindle
CCIDAGO:0005829cytosol
CCIEAGO:0005886plasma membrane
CCIEAGO:0005902microvillus
CCISSGO:0005938cell cortex
CCIDAGO:0015629actin cytoskeleton
CCISSGO:0030659cytoplasmic vesicle membrane
CCIEAGO:0048471perinuclear region of cytoplasm
BPIMPGO:0006974cellular response to DNA damage stimulus
BPIEAGO:0007275multicellular organism development
BPIEAGO:0015031protein transport
BPISSGO:0016192vesicle-mediated transport
BPIEAGO:0035556intracellular signal transduction
BPISSGO:0040038polar body extrusion after meiotic divisions
BPIMPGO:0042177negative regulation of protein catabolic process
BPIMPGO:0043066negative regulation of apoptotic process
BPISSGO:0046907intracellular transport
BPISSGO:0048477oogenesis
BPISSGO:0051295establishment of meiotic spindle localization
BPISSGO:0051758homologous chromosome movement towards spindle pole involved in homologous chromosome segregation
BPISSGO:0070649formin-nucleated actin cable assembly
BPIMPGO:0071456cellular response to hypoxia

Gene expression in normal tissue: FMN2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in FMN2


DatabasePathway IDPathway Des.

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD679Bistramide A4
iGMDRD394BX-7954
iGMDRD280CYTOCHALASIN B9
iGMDRD797ISOX DUAL1
iGMDRD61Kinetin riboside2
iGMDRD152179324-69-74
iGMDRD316N9-Isopropyl-olomoucine1
iGMDRD639YK 4-2792
iGMDRD427ABT7373
iGMDRD144NSC953973
iGMDRD599Salermide1
iGMDRD640CAY106183
iGMDRD23Gossypol2
iGMDRD598QS-112
iGMDRD399Selumetinib2
iGMDRD100Zebularine3
iGMDRD188Piperlongumine2
iGMDRD577BIX012942
iGMDRD171Pemetrexed1
iGMDRD187BRD98762
iGMDRD885Compound 1103
iGMDRD474Avrainvillamide2
iGMDRD138PX 123
iGMDRD255SB2250023
iGMDRD132(-)-gallocatechin-3-O-gallate8
iGMDRD237ABT-7512
iGMDRD698Neratinib2
iGMDRD351GW843682X1
iGMDRD345Compound 10b [PMID: 11504634]1
iGMDRD424Tamatinib3
iGMDRD150RITA6
iGMDRD79Gemcitabine3
iGMDRD486Tosedostat5
iGMDRD300Tozasertib3
iGMDRD322FK 8661
iGMDRD82Quiflapon1
iGMDRD353PD03259011
iGMDRD871BRD63682
iGMDRD67PENFLURIDOL3
iGMDRD329Merck607
iGMDRD434BMS-5369243
iGMDRD6AM-5804
iGMDRD77Itraconazole1
iGMDRD481Dactolisib1
iGMDRD158NSC1415402
iGMDRD121GMX17782
iGMDRD137Indisulam4
iGMDRD202Curcumin3
iGMDRD5Tyrphostin AG 14782

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in FMN2

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