FMN2
Summary: This gene is a member of the formin homology protein family. The encoded protein is thought to have essential roles in organization of the actin cytoskeleton and in cell polarity. This protein mediates the formation of an actin mesh that positions the spindle during oogenesis and also regulates the formation of actin filaments in the nucleus. This protein also forms a perinuclear actin/focal-adhesion system that regulates the shape and position of the nucleus during cell migration. Mutations in this gene have been associated with infertility and also with an autosomal recessive form of intellectual disability (MRT47). Alternatively spliced transcript variants have been identified. [provided by RefSeq, Jul 2017].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| formin 2 | MIM:606373 | Ensembl:ENSG00000155816 | HGNC:HGNC:14074 | PA28185 | 1q43 |
GO terms in FMN2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | ND | GO:0003674 | molecular_function |
| MF | IDA | GO:0003779 | actin binding |
| CC | IDA | GO:0005730 | nucleolus |
| CC | IEA | GO:0005789 | endoplasmic reticulum membrane |
| CC | IEA | GO:0005819 | spindle |
| CC | IDA | GO:0005829 | cytosol |
| CC | IEA | GO:0005886 | plasma membrane |
| CC | IEA | GO:0005902 | microvillus |
| CC | ISS | GO:0005938 | cell cortex |
| CC | IDA | GO:0015629 | actin cytoskeleton |
| CC | ISS | GO:0030659 | cytoplasmic vesicle membrane |
| CC | IEA | GO:0048471 | perinuclear region of cytoplasm |
| BP | IMP | GO:0006974 | cellular response to DNA damage stimulus |
| BP | IEA | GO:0007275 | multicellular organism development |
| BP | IEA | GO:0015031 | protein transport |
| BP | ISS | GO:0016192 | vesicle-mediated transport |
| BP | IEA | GO:0035556 | intracellular signal transduction |
| BP | ISS | GO:0040038 | polar body extrusion after meiotic divisions |
| BP | IMP | GO:0042177 | negative regulation of protein catabolic process |
| BP | IMP | GO:0043066 | negative regulation of apoptotic process |
| BP | ISS | GO:0046907 | intracellular transport |
| BP | ISS | GO:0048477 | oogenesis |
| BP | ISS | GO:0051295 | establishment of meiotic spindle localization |
| BP | ISS | GO:0051758 | homologous chromosome movement towards spindle pole involved in homologous chromosome segregation |
| BP | ISS | GO:0070649 | formin-nucleated actin cable assembly |
| BP | IMP | GO:0071456 | cellular response to hypoxia |
Gene expression in normal tissue: FMN2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in FMN2
| Database | Pathway ID | Pathway Des. |
|---|
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD679 | Bistramide A | 4 |
| iGMDRD394 | BX-795 | 4 |
| iGMDRD280 | CYTOCHALASIN B | 9 |
| iGMDRD797 | ISOX DUAL | 1 |
| iGMDRD61 | Kinetin riboside | 2 |
| iGMDRD152 | 179324-69-7 | 4 |
| iGMDRD316 | N9-Isopropyl-olomoucine | 1 |
| iGMDRD639 | YK 4-279 | 2 |
| iGMDRD427 | ABT737 | 3 |
| iGMDRD144 | NSC95397 | 3 |
| iGMDRD599 | Salermide | 1 |
| iGMDRD640 | CAY10618 | 3 |
| iGMDRD23 | Gossypol | 2 |
| iGMDRD598 | QS-11 | 2 |
| iGMDRD399 | Selumetinib | 2 |
| iGMDRD100 | Zebularine | 3 |
| iGMDRD188 | Piperlongumine | 2 |
| iGMDRD577 | BIX01294 | 2 |
| iGMDRD171 | Pemetrexed | 1 |
| iGMDRD187 | BRD9876 | 2 |
| iGMDRD885 | Compound 110 | 3 |
| iGMDRD474 | Avrainvillamide | 2 |
| iGMDRD138 | PX 12 | 3 |
| iGMDRD255 | SB225002 | 3 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 8 |
| iGMDRD237 | ABT-751 | 2 |
| iGMDRD698 | Neratinib | 2 |
| iGMDRD351 | GW843682X | 1 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 1 |
| iGMDRD424 | Tamatinib | 3 |
| iGMDRD150 | RITA | 6 |
| iGMDRD79 | Gemcitabine | 3 |
| iGMDRD486 | Tosedostat | 5 |
| iGMDRD300 | Tozasertib | 3 |
| iGMDRD322 | FK 866 | 1 |
| iGMDRD82 | Quiflapon | 1 |
| iGMDRD353 | PD0325901 | 1 |
| iGMDRD871 | BRD6368 | 2 |
| iGMDRD67 | PENFLURIDOL | 3 |
| iGMDRD329 | Merck60 | 7 |
| iGMDRD434 | BMS-536924 | 3 |
| iGMDRD6 | AM-580 | 4 |
| iGMDRD77 | Itraconazole | 1 |
| iGMDRD481 | Dactolisib | 1 |
| iGMDRD158 | NSC141540 | 2 |
| iGMDRD121 | GMX1778 | 2 |
| iGMDRD137 | Indisulam | 4 |
| iGMDRD202 | Curcumin | 3 |
| iGMDRD5 | Tyrphostin AG 1478 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in FMN2
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