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iGMDRD329

Canonical SMILES: CC(=O)NC1=CC=C(C=C1)C(=O)NC2=C(C=CC(=C2)C3=CC=CS3)N

InChI: InChI=1S/C19H17N3O2S/c1-12(23)21-15-7-4-13(5-8-15)19(24)22-17-11-14(6-9-16(17)20)18-3-2-10-25-18/h2-11H,20H2,1H3,(H,21,23)(H,22,24)

InChI Key: ABZSPJVXTTUFAA-UHFFFAOYSA-N

Standard Name	Pubchem CID	Drug Status	Drug Type
Merck60	6918880	Alone	Small Molecule

Drug Targets:

HDAC1 HDAC2

Drug-model tissue-cancer distribution: Bubble Plot

Drug-gene pathway enrichments

Drug-gene GO enrichments

Drug-Gene: Aster Plot

Gene ID	Gene Name	Model Num.
3696	ITGB8	5
64901	RANBP17	6
1147	CHUK	2
27125	AFF4	5
4854	NOTCH3	2
8999	CDKL2	3
6664	SOX11	6
7074	TIAM1	2
5027	P2RX7	3
10221	TRIB1	3
1464	CSPG4	3
10641	NPRL2	3
23085	ERC1	2
6491	STIL	6
132	ADK	15
3383	ICAM1	3
11183	MAP4K5	6
79947	DHDDS	1
4168	MCF2	5
2956	MSH6	1
2200	FBN1	6
150465	TTL	3
10783	NEK6	5
1969	EPHA2	2
347365	ITIH6	6
3845	KRAS	3
51347	TAOK3	2
4750	NEK1	2
8289	ARID1A	2
80070	ADAMTS20	2
137994	LETM2	6
701	BUB1B	2
3939	LDHA	6
11193	WBP4	2
2335	FN1	3
79092	CARD14	2
53616	ADAM22	2
4352	MPL	3
1263	PLK3	4
9475	ROCK2	5
83942	TSSK1B	4
3326	HSP90AB1	5
9869	SETDB1	3
10395	DLC1	1
353345	GPR141	8
5133	PDCD1	4
3069	HDLBP	2
11116	FGFR1OP	2
6657	SOX2	1
390502	SERPINA2	1
56776	FMN2	7
23235	SIK2	4
10863	ADAM28	3
6598	SMARCB1	1
4170	MCL1	4
1607	DGKB	5
3320	HSP90AA1	2
22853	LMTK2	3
23310	NCAPD3	1
6732	SRPK1	2
5298	PI4KB	5
27	ABL2	4
8749	ADAM18	1
55534	MAML3	2
8737	RIPK1	3
341676	NEK5	1
340371	NRBP2	3
22821	RASA3	2
9816	URB2	3
1545	CYP1B1	1
2249	FGF4	2
54822	TRPM7	1
112858	TP53RK	2
1387	CREBBP	6
11329	STK38	2
5756	TWF1	1
2043	EPHA4	2
55023	PHIP	3
5788	PTPRC	1
56164	STK31	6
10013	HDAC6	3
5579	PRKCB	11
11200	CHEK2	6
7133	TNFRSF1B	2
51755	CDK12	1
9048	ARTN	3
5596	MAPK4	2
9411	ARHGAP29	3
3604	TNFRSF9	2
29998	BICRA	3
8295	TRRAP	2
10438	C1D	3
11122	PTPRT	8
23617	TSSK2	3
9024	BRSK2	3
5159	PDGFRB	5
55351	STK32B	1
5166	PDK4	6
5314	PKHD1	2
7158	TP53BP1	3
145264	SERPINA12	6
974	CD79B	3
2033	EP300	3
9578	CDC42BPB	4
23522	KAT6B	7
55728	N4BP2	6
25865	PRKD2	6
10006	ABI1	3
440279	UNC13C	4
340156	MYLK4	5
5743	PTGS2	5
84033	OBSCN	3
342667	STAC2	2
11073	TOPBP1	6
7025	NR2F1	4
1880	GPR183	9
122011	CSNK1A1L	4
3621	ING1	6
9693	RAPGEF2	2
608	TNFRSF17	3
4478	MSN	3
3714	JAG2	2
8852	AKAP4	3
3556	IL1RAP	2
329	BIRC2	5
64083	GOLPH3	1
9175	MAP3K13	3
5468	PPARG	4
200576	PIKFYVE	3
8313	AXIN2	7
6091	ROBO1	2
2042	EPHA3	2
1050	CEBPA	1
116986	AGAP2	4
51343	FZR1	4
5330	PLCB2	4
114548	NLRP3	2
730249	ACOD1	6
80129	CCDC170	3
9636	ISG15	3
11169	WDHD1	3
4216	MAP3K4	2
2736	GLI2	5
2908	NR3C1	4
83990	BRIP1	3
51804	SIX4	2
5601	MAPK9	3
4194	MDM4	3
284217	LAMA1	3
269	AMHR2	2
2045	EPHA7	3
1992	SERPINB1	2
171019	ADAMTS19	3
22858	ICK	2
65266	WNK4	3
287015	TRIM42	6
57476	GRAMD1B	7
83983	TSSK6	3
54899	PXK	4
7486	WRN	1
29775	CARD10	2
440730	TRIM67	3
5580	PRKCD	3
4140	MARK3	1
6416	MAP2K4	4
92	ACVR2A	2
57510	XPO5	6
64170	CARD9	1
6709	SPTAN1	2
1973	EIF4A1	3
10087	COL4A3BP	3
6098	ROS1	6
9472	AKAP6	3
157285	PRAG1	1
54437	SEMA5B	1
8515	ITGA10	2
9590	AKAP12	4
3685	ITGAV	4
3667	IRS1	2
2580	GAK	6
83903	HASPIN	1
28996	HIPK2	2
575	ADGRB1	2
53942	CNTN5	4
5924	RASGRF2	5
4087	SMAD2	4
2734	GLG1	4
84433	CARD11	6
9096	TBX18	6
4058	LTK	2
1123	CHN1	2
5289	PIK3C3	4
898	CCNE1	2
2272	FHIT	6
2066	ERBB4	2
8798	DYRK4	3
28951	TRIB2	2
10413	YAP1	3
2201	FBN2	4
7184	HSP90B1	3
5108	PCM1	4
139728	PNCK	2
57523	NYNRIN	2
83694	RPS6KL1	3
657	BMPR1A	5
3236	HOXD10	9
5336	PLCG2	3
9874	TLK1	3
11143	KAT7	6
10018	BCL2L11	5
8743	TNFSF10	2
58508	KMT2C	3
6092	ROBO2	3
4602	MYB	1
79058	ASPSCR1	4
4296	MAP3K11	3
2322	FLT3	5
57194	ATP10A	2
25836	NIPBL	3
3791	KDR	1
4292	MLH1	2
114788	CSMD3	5
6184	RPN1	3
54498	SMOX	9
7249	TSC2	6
105	ADARB2	5
4869	NPM1	2
863	CBFA2T3	2
1555	CYP2B6	2
1102	RCBTB2	3
23043	TNIK	3
7422	VEGFA	1
55437	STRADB	4
2309	FOXO3	1
7038	TG	1
9965	FGF19	1
6197	RPS6KA3	3
57188	ADAMTSL3	2
3187	HNRNPH1	3
57105	CYSLTR2	2
55589	BMP2K	3
57591	MRTFA	2
136332	LRGUK	3
676	BRDT	2
984	CDK11B	2
5650	KLK7	8
5871	MAP4K2	2
9401	RECQL4	3
23365	ARHGEF12	7
2081	ERN1	3
4026	LPP	3
8997	KALRN	6
4437	MSH3	8
6795	AURKC	3
2071	ERCC3	4
23269	MGA	3
6280	S100A9	2
23469	PHF3	3
51284	TLR7	6
7471	WNT1	2
3559	IL2RA	3
672	BRCA1	7
2668	GDNF	3
7204	TRIO	3
256536	TCERG1L	2
9252	RPS6KA5	2
78989	COLEC11	1
835	CASP2	1
23373	CRTC1	3
285220	EPHA6	5
3417	IDH1	4
23678	SGK3	2
85414	SLC45A3	3
5606	MAP2K3	2
5069	PAPPA	3
10926	DBF4	5
64840	PORCN	5
56997	COQ8A	3
57144	PAK5	3
286133	SCARA5	6
4214	MAP3K1	1
3702	ITK	3
602	BCL3	4
8731	RNMT	1
1198	CLK3	2
9972	NUP153	3
3239	HOXD13	3
84823	LMNB2	3
5290	PIK3CA	2
92335	STRADA	2
2931	GSK3A	4
5034	P4HB	5
4145	MATK	9
1687	GSDME	3
8202	NCOA3	2
253260	RICTOR	2
5366	PMAIP1	3
5045	FURIN	3
7043	TGFB3	3
2318	FLNC	8
10565	ARFGEF1	4
64919	BCL11B	3
57154	SMURF1	2
3458	IFNG	2
607	BCL9	3
10155	TRIM28	3
7075	TIE1	5
8445	DYRK2	5
157680	VPS13B	4
3065	HDAC1	2
4609	MYC	6
90956	ADCK2	3
8021	NUP214	7
1459	CSNK2A2	2
10461	MERTK	4
90427	BMF	2
8795	TNFRSF10B	2
26278	SACS	4
894	CCND2	4
5462	POU5F1B	3
896	CCND3	3
29951	PDZRN4	2
51701	NLK	2
5592	PRKG1	3
1594	CYP27B1	9
5747	PTK2	6
3635	INPP5D	3
1653	DDX1	10
7917	BAG6	5
1544	CYP1A2	6
10000	AKT3	3
9159	PCSK7	3
3949	LDLR	8
56924	PAK6	2
203102	ADAM32	3
673	BRAF	1
7153	TOP2A	7
57082	KNL1	5
1213	CLTC	2
4790	NFKB1	3
1769	DNAH8	3
988	CDC5L	2
23532	PRAME	2
4863	NPAT	4
780	DDR1	3
8924	HERC2	6
2078	ERG	2
89795	NAV3	1
65268	WNK2	2
11126	CD160	2
6095	RORA	6
29844	TFPT	3
7301	TYRO3	1
5205	ATP8B1	2
7468	NSD2	7
8029	CUBN	10
8626	TP63	2
4298	MLLT1	2
9321	TRIP11	2
10253	SPRY2	3
9451	EIF2AK3	5
1977	EIF4E	4
4853	NOTCH2	2
1230	CCR1	2
162968	ZNF497	2
157	GRK3	4
5563	PRKAA2	5
23396	PIP5K1C	5
23049	SMG1	5
10010	TANK	2
57521	RPTOR	5
208	AKT2	6
2796	GNRH1	3
1869	E2F1	1
22883	CLSTN1	2
667	DST	6
284086	NEK8	2
83666	PARP9	2
2897	GRIK1	2
23542	MAPK8IP2	2
6770	STAR	4
2188	FANCF	3
6146	RPL22	1
2324	FLT4	5
6009	RHEB	9
2264	FGFR4	7
177	AGER	5
5896	RAG1	3
6498	SKIL	2
4055	LTBR	6
28954	REM1	4
7273	TTN	1
1018	CDK3	3
91807	MYLK3	3
79834	PEAK1	5
5582	PRKCG	3
995	CDC25C	6
7465	WEE1	3
7454	WAS	6
7036	TFR2	6
596	BCL2	3
85415	RHPN2	5
23389	MED13L	3
8028	MLLT10	3
2277	VEGFD	2
54904	NSD3	3
23411	SIRT1	5
8648	NCOA1	3
3161	HMMR	5
54861	SNRK	3
2046	EPHA8	3
7150	TOP1	6
8821	INPP4B	3
5532	PPP3CB	1
22843	PPM1E	3
8394	PIP5K1A	3
2353	FOS	2
1643	DDB2	2
54738	FEV	3
4297	KMT2A	3
5291	PIK3CB	2
10076	PTPRU	4
7248	TSC1	3
9748	SLK	1
4619	MYH1	2
2869	GRK5	2
2690	GHR	4
2041	EPHA1	2
9021	SOCS3	8
100124696	TEC	6
5395	PMS2	3
860	RUNX2	6
778	CACNA1F	3
1789	DNMT3B	3
53353	LRP1B	3
55289	ACOXL	3
1281	COL3A1	3
9659	PDE4DIP	8
9201	DCLK1	7
63976	PRDM16	7
2049	EPHB3	3
54101	RIPK4	2
5335	PLCG1	2
4628	MYH10	3
5927	KDM5A	3
1385	CREB1	2
55007	FAM118A	2
1719	DHFR	5
2321	FLT1	3
6196	RPS6KA2	8
2131	EXT1	1
22982	DIP2C	3
7099	TLR4	3
2157	F8	3
53335	BCL11A	3
5506	PPP1R3A	2
1627	DBN1	3
57147	SCYL3	6
6778	STAT6	2
4221	MEN1	5
8899	PRPF4B	2
6194	RPS6	3
23301	EHBP1	1
65267	WNK3	2
8428	STK24	10
6777	STAT5B	2
3552	IL1A	2
80216	ALPK1	3
5932	RBBP8	4
3977	LIFR	6
4261	CIITA	9
444	ASPH	3
11076	TPPP	3
23250	ATP11A	2
182	JAG1	3
3662	IRF4	2
1760	DMPK	3
5087	PBX1	3
6653	SORL1	3
5925	RB1	1
1515	CTSV	2
5584	PRKCI	2
862	RUNX1T1	2
10420	TESK2	2
7403	KDM6A	4
54790	TET2	4
2308	FOXO1	1
2534	FYN	2
1432	MAPK14	3
7508	XPC	6
8841	HDAC3	5
5586	PKN2	3
4205	MEF2A	2
7040	TGFB1	2
30849	PIK3R4	1
55959	SULF2	6
3488	IGFBP5	2
79728	PALB2	2
4915	NTRK2	3
4299	AFF1	3
2651	GCNT2	3
11086	ADAM29	4
142	PARP1	4
2261	FGFR3	3
23072	HECW1	3
5567	PRKACB	2
84197	POMK	1
55422	ZNF331	7
1013	CDH15	3
3092	HIP1	3
54518	APBB1IP	2
4763	NF1	3
8814	CDKL1	6
5260	PHKG1	2
4613	MYCN	7
494551	WEE2	3
440270	GOLGA8B	2
57096	RPGRIP1	3
2044	EPHA5	2
4593	MUSK	3
4629	MYH11	3
30811	HUNK	3
1608	DGKG	3
7294	TXK	4
6868	ADAM17	3
23112	TNRC6B	6
2178	FANCE	2
1499	CTNNB1	2
2444	FRK	3
56155	TEX14	2
5602	MAPK10	1
2892	GRIA3	3
1795	DOCK3	3
11035	RIPK3	2
4486	MST1R	3
5624	PROC	2
5970	RELA	4
1488	CTBP2	2

Gene in drug-gene network: Network Plot

Models in Merck60

SITE

DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.