SERPINB1
Summary: The protein encoded by this gene is a member of the serpin family of proteinase inhibitors. Members of this family maintain homeostasis by neutralizing overexpressed proteinase activity through their function as suicide substrates. This protein inhibits the neutrophil-derived proteinases neutrophil elastase, cathepsin G, and proteinase-3 and thus protects tissues from damage at inflammatory sites. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| serpin family B member 1 | MIM:130135 | Ensembl:ENSG00000021355 | HGNC:HGNC:3311 | PA35046 | 6p25.2 |
GO terms in SERPINB1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0004867 | serine-type endopeptidase inhibitor activity |
| MF | NAS | GO:0004867 | serine-type endopeptidase inhibitor activity |
| BP | IBA | GO:0010951 | negative regulation of endopeptidase activity |
| BP | IEA | GO:0010951 | negative regulation of endopeptidase activity |
| BP | TAS | GO:0043312 | neutrophil degranulation |
| CC | HDA | GO:0005576 | extracellular region |
| CC | TAS | GO:0005576 | extracellular region |
| CC | HDA | GO:0005615 | extracellular space |
| CC | IBA | GO:0005615 | extracellular space |
| CC | HDA | GO:0016020 | membrane |
| CC | TAS | GO:0034774 | secretory granule lumen |
| CC | HDA | GO:0062023 | collagen-containing extracellular matrix |
| CC | HDA | GO:0070062 | extracellular exosome |
Gene expression in normal tissue: SERPINB1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SERPINB1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa05146 | Amoebiasis - Homo sapiens (human) |
| wikipathways | WP2877 | Vitamin D Receptor Pathway |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-6798695 | Neutrophil degranulation |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD512 | nutlin 3 | 1 |
| iGMDRD486 | Tosedostat | 3 |
| iGMDRD405 | PIK-75 | 1 |
| iGMDRD150 | RITA | 3 |
| iGMDRD314 | Tanespimycin | 4 |
| iGMDRD435 | BI-2536 | 6 |
| iGMDRD154 | NSC23766 | 6 |
| iGMDRD177 | Teniposide | 1 |
| iGMDRD123 | Isoevodiamine | 1 |
| iGMDRD158 | NSC141540 | 5 |
| iGMDRD137 | Indisulam | 4 |
| iGMDRD267 | Oligomycin A | 3 |
| iGMDRD329 | Merck60 | 2 |
| iGMDRD414 | MST-312 | 3 |
| iGMDRD871 | BRD6368 | 6 |
| iGMDRD353 | PD0325901 | 2 |
| iGMDRD886 | Compound 1541A | 3 |
| iGMDRD300 | Tozasertib | 4 |
| iGMDRD420 | Leucascandrolide A | 6 |
| iGMDRD126 | Tipifarnib | 2 |
| iGMDRD781 | Sirolimus | 3 |
| iGMDRD427 | ABT737 | 7 |
| iGMDRD375 | GW-405833 | 3 |
| iGMDRD297 | Austocystin D | 5 |
| iGMDRD280 | CYTOCHALASIN B | 2 |
| iGMDRD255 | SB225002 | 3 |
| iGMDRD802 | 4-methylfasudil | 2 |
| iGMDRD474 | Avrainvillamide | 3 |
| iGMDRD801 | 2,4-dideoxy-DC-45-A2 | 2 |
| iGMDRD885 | Compound 110 | 3 |
| iGMDRD318 | PAC-1 | 6 |
| iGMDRD187 | BRD9876 | 2 |
| iGMDRD294 | Batimastat | 2 |
| iGMDRD171 | Pemetrexed | 1 |
| iGMDRD782 | DC-45-A2 | 5 |
| iGMDRD506 | Fedratinib | 13 |
| iGMDRD562 | Navitoclax | 5 |
| iGMDRD887 | Compound 23 citrate | 2 |
| iGMDRD74 | Idarubicin | 4 |
| iGMDRD23 | Gossypol | 3 |
| iGMDRD451 | Serdemetan | 5 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SERPINB1
CLASSFICATION
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