SERPINB1
Summary: The protein encoded by this gene is a member of the serpin family of proteinase inhibitors. Members of this family maintain homeostasis by neutralizing overexpressed proteinase activity through their function as suicide substrates. This protein inhibits the neutrophil-derived proteinases neutrophil elastase, cathepsin G, and proteinase-3 and thus protects tissues from damage at inflammatory sites. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:130135 Ensembl IDEnsembl:ENSG00000021355 HGNC IDHGNC:HGNC:3311 PHARMGKB IDPA35046 Map Location6p25.2 | |||||
GO terms in SERPINB1
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0004867 | serine-type endopeptidase inhibitor activity |
| MF | NAS | GO:0004867 | serine-type endopeptidase inhibitor activity |
| BP | IBA | GO:0010951 | negative regulation of endopeptidase activity |
| BP | IEA | GO:0010951 | negative regulation of endopeptidase activity |
| BP | TAS | GO:0043312 | neutrophil degranulation |
| CC | HDA | GO:0005576 | extracellular region |
Gene expression in normal tissue: SERPINB1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SERPINB1
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa05146 | Amoebiasis - Homo sapiens (human) |
| wikipathways | WP2877 | Vitamin D Receptor Pathway |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-6798695 | Neutrophil degranulation |
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Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SERPINB1
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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