SERPINB1


Summary: The protein encoded by this gene is a member of the serpin family of proteinase inhibitors. Members of this family maintain homeostasis by neutralizing overexpressed proteinase activity through their function as suicide substrates. This protein inhibits the neutrophil-derived proteinases neutrophil elastase, cathepsin G, and proteinase-3 and thus protects tissues from damage at inflammatory sites. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
serpin family B member 1MIM:130135Ensembl:ENSG00000021355HGNC:HGNC:3311PA350466p25.2

GO terms in SERPINB1


Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0004867serine-type endopeptidase inhibitor activity
MFNASGO:0004867serine-type endopeptidase inhibitor activity
BPIBAGO:0010951negative regulation of endopeptidase activity
BPIEAGO:0010951negative regulation of endopeptidase activity
BPTASGO:0043312neutrophil degranulation
CCHDAGO:0005576extracellular region
CCTASGO:0005576extracellular region
CCHDAGO:0005615extracellular space
CCIBAGO:0005615extracellular space
CCHDAGO:0016020membrane
CCTASGO:0034774secretory granule lumen
CCHDAGO:0062023collagen-containing extracellular matrix
CCHDAGO:0070062extracellular exosome

Gene expression in normal tissue: SERPINB1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SERPINB1


DatabasePathway IDPathway Des.
kegghsa05146Amoebiasis - Homo sapiens (human)
wikipathwaysWP2877Vitamin D Receptor Pathway
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-6798695Neutrophil degranulation

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD512nutlin 31
iGMDRD486Tosedostat3
iGMDRD405PIK-751
iGMDRD150RITA3
iGMDRD314Tanespimycin4
iGMDRD435BI-25366
iGMDRD154NSC237666
iGMDRD177Teniposide1
iGMDRD123Isoevodiamine1
iGMDRD158NSC1415405
iGMDRD137Indisulam4
iGMDRD267Oligomycin A3
iGMDRD329Merck602
iGMDRD414MST-3123
iGMDRD871BRD63686
iGMDRD353PD03259012
iGMDRD886Compound 1541A3
iGMDRD300Tozasertib4
iGMDRD420Leucascandrolide A6
iGMDRD126Tipifarnib2
iGMDRD781Sirolimus3
iGMDRD427ABT7377
iGMDRD375GW-4058333
iGMDRD297Austocystin D5
iGMDRD280CYTOCHALASIN B2
iGMDRD255SB2250023
iGMDRD8024-methylfasudil2
iGMDRD474Avrainvillamide3
iGMDRD8012,4-dideoxy-DC-45-A22
iGMDRD885Compound 1103
iGMDRD318PAC-16
iGMDRD187BRD98762
iGMDRD294Batimastat2
iGMDRD171Pemetrexed1
iGMDRD782DC-45-A25
iGMDRD506Fedratinib13
iGMDRD562Navitoclax5
iGMDRD887Compound 23 citrate2
iGMDRD74Idarubicin4
iGMDRD23Gossypol3
iGMDRD451Serdemetan5

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SERPINB1

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