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iGMDRD451

Canonical SMILES: C1=CC=C2C(=C1)C(=CN2)CCNC3=CC=C(C=C3)NC4=CC=NC=C4

InChI: InChI=1S/C21H20N4/c1-2-4-21-20(3-1)16(15-24-21)9-14-23-17-5-7-18(8-6-17)25-19-10-12-22-13-11-19/h1-8,10-13,15,23-24H,9,14H2,(H,22,25)

InChI Key: CEGSUKYESLWKJP-UHFFFAOYSA-N

Standard Name	CHEMBL	Pubchem CID	DRUGBANK ID	Drug Status	Drug Type
Serdemetan	CHEMBL2137530	11609600	DB12027	Alone	Small Molecule

Drug Class:

Amines Biogenic Amines Biogenic Monoamines Heterocyclic Compounds Heterocyclic Compounds, 2-Ring Indoles Radiation-Sensitizing Agents

Drug Targets:

MDM2

Drug Pathways:

p53 pathway

Drug-model tissue-cancer distribution: Bubble Plot

Drug-gene pathway enrichments

Drug-gene GO enrichments

Drug-Gene: Aster Plot

Gene ID	Gene Name	Model Num.
331	XIAP	2
64901	RANBP17	5
27102	EIF2AK1	2
4854	NOTCH3	2
8999	CDKL2	2
6664	SOX11	3
8019	BRD3	2
10460	TACC3	3
5027	P2RX7	2
10903	MTMR11	3
10221	TRIB1	3
10641	NPRL2	1
8444	DYRK3	2
10987	COPS5	3
9261	MAPKAPK2	3
132	ADK	5
5933	RBL1	2
11183	MAP4K5	2
2986	GUCY2F	5
114801	TMEM200A	1
79947	DHDDS	3
2956	MSH6	1
2200	FBN1	3
57679	ALS2	2
150465	TTL	2
3708	ITPR1	2
10783	NEK6	3
9706	ULK2	3
7272	TTK	5
4750	NEK1	2
5295	PIK3R1	2
23097	CDK19	2
8289	ARID1A	4
6351	CCL4	3
137994	LETM2	3
26511	CHIC2	3
3939	LDHA	3
3431	SP110	4
4352	MPL	3
9475	ROCK2	2
6597	SMARCA4	3
3326	HSP90AB1	2
4036	LRP2	2
10395	DLC1	3
5133	PDCD1	4
843	CASP10	3
9530	BAG4	3
7444	VRK2	2
390502	SERPINA2	4
53944	CSNK1G1	3
5079	PAX5	3
64783	RBM15	1
57580	PREX1	1
10892	MALT1	3
4313	MMP2	6
6598	SMARCB1	7
4170	MCL1	1
1607	DGKB	2
3066	HDAC2	2
2241	FER	2
6455	SH3GL1	3
6887	TAL2	5
114908	TMEM123	1
54822	TRPM7	2
80122	MAP3K19	2
28231	SLCO4A1	2
114783	LMTK3	2
202374	STK32A	2
1387	CREBBP	3
2043	EPHA4	2
10013	HDAC6	2
5579	PRKCB	3
11200	CHEK2	3
31	ACACA	3
51755	CDK12	3
9411	ARHGAP29	2
1111	CHEK1	2
26576	SRPK3	2
11122	PTPRT	3
5899	RALB	2
7373	COL14A1	5
5166	PDK4	3
5314	PKHD1	2
55294	FBXW7	2
23522	KAT6B	3
55728	N4BP2	3
57670	KIAA1549	2
284521	OR2L13	3
4301	AFDN	1
5743	PTGS2	3
84033	OBSCN	2
342977	NANOS3	4
256646	NUTM1	2
122011	CSNK1A1L	1
9693	RAPGEF2	2
23012	STK38L	4
6256	RXRA	3
32	ACACB	2
3556	IL1RAP	4
329	BIRC2	1
2688	GH1	3
26353	HSPB8	2
22806	IKZF3	1
10342	TFG	2
22984	PDCD11	1
114548	NLRP3	3
83990	BRIP1	4
51804	SIX4	3
3688	ITGB1	3
269	AMHR2	2
7424	VEGFC	3
55681	SCYL2	2
2045	EPHA7	2
140901	STK35	3
1992	SERPINB1	5
238	ALK	2
983	CDK1	3
83983	TSSK6	3
26750	RPS6KC1	2
783	CACNB2	2
6416	MAP2K4	1
9759	HDAC4	2
92	ACVR2A	3
1973	EIF4A1	3
10087	COL4A3BP	3
6793	STK10	3
5591	PRKDC	4
6098	ROS1	2
2778	GNAS	3
51433	ANAPC5	2
80243	PREX2	2
575	ADGRB1	5
5924	RASGRF2	5
7533	YWHAH	2
5289	PIK3C3	2
2272	FHIT	3
2066	ERBB4	2
79442	LRRC2	3
10413	YAP1	2
7184	HSP90B1	5
139728	PNCK	1
9794	MAML1	2
23048	FNBP1	2
157753	TMEM74	3
2868	GRK4	2
5336	PLCG2	2
9874	TLK1	3
6092	ROBO2	2
4088	SMAD3	6
25836	NIPBL	1
8218	CLTCL1	2
397	ARHGDIB	3
356	FASLG	3
2263	FGFR2	3
65243	ZFP69B	3
5604	MAP2K1	1
4869	NPM1	2
863	CBFA2T3	2
8874	ARHGEF7	1
23043	TNIK	1
7422	VEGFA	3
7038	TG	1
2177	FANCD2	2
50945	TBX22	1
6535	SLC6A8	2
7175	TPR	3
80205	CHD9	2
57578	UNC79	2
4026	LPP	2
4437	MSH3	3
7994	KAT6A	4
4089	SMAD4	1
256536	TCERG1L	2
9252	RPS6KA5	2
78989	COLEC11	4
23373	CRTC1	3
285220	EPHA6	2
51366	UBR5	1
3426	CFI	4
3417	IDH1	2
23678	SGK3	4
5606	MAP2K3	3
5297	PI4KA	2
501	ALDH7A1	1
10769	PLK2	2
340533	NEXMIF	2
1198	CLK3	4
9972	NUP153	2
3239	HOXD13	2
2187	FANCB	3
3562	IL3	3
3720	JARID2	4
2931	GSK3A	8
26524	LATS2	2
5366	PMAIP1	3
10565	ARFGEF1	1
2030	SLC29A1	3
675	BRCA2	4
3458	IFNG	1
7075	TIE1	2
1956	EGFR	1
3065	HDAC1	3
4609	MYC	3
90956	ADCK2	3
2624	GATA2	3
3308	HSPA4	1
5789	PTPRD	7
6776	STAT5A	1
51701	NLK	3
3553	IL1B	2
5747	PTK2	2
5156	PDGFRA	3
1544	CYP1A2	3
91754	NEK9	4
27330	RPS6KA6	5
3949	LDLR	4
7153	TOP2A	2
1981	EIF4G1	5
1213	CLTC	3
4790	NFKB1	3
6011	GRK1	3
1769	DNAH8	5
22976	PAXIP1	2
23532	PRAME	6
120892	LRRK2	2
89795	NAV3	3
867	CBL	4
6095	RORA	3
7301	TYRO3	3
9113	LATS1	3
5294	PIK3CG	5
664	BNIP3	6
23598	PATZ1	3
23396	PIP5K1C	3
23049	SMG1	2
10010	TANK	3
8312	AXIN1	2
1806	DPYD	3
7030	TFE3	3
1316	KLF6	3
667	DST	2
53836	GPR87	2
352909	DNAAF3	3
1950	EGF	2
2264	FGFR4	4
177	AGER	2
658	BMPR1B	1
23090	ZNF423	3
6498	SKIL	4
28954	REM1	2
6789	STK4	2
7036	TFR2	3
55359	STYK1	3
6787	NEK4	2
2277	VEGFD	2
3161	HMMR	2
221895	JAZF1	3
5532	PPP3CB	3
286151	FBXO43	5
57820	CCNB1IP1	3
1662	DDX10	3
10595	ERN2	2
4297	KMT2A	2
4619	MYH1	2
332	BIRC5	2
57680	CHD8	3
2869	GRK5	2
1399	CRKL	2
64764	CREB3L2	2
10111	RAD50	2
3181	HNRNPA2B1	3
1281	COL3A1	2
6093	ROCK1	2
3557	IL1RN	6
6760	SS18	3
2776	GNAQ	3
5927	KDM5A	5
1719	DHFR	5
5583	PRKCH	2
1975	EIF4B	3
23139	MAST2	2
22982	DIP2C	5
6778	STAT6	2
4067	LYN	2
8428	STK24	3
4772	NFATC1	3
3552	IL1A	3
80216	ALPK1	5
5932	RBBP8	4
4261	CIITA	4
170685	NUDT10	5
2122	MECOM	1
3662	IRF4	2
3815	KIT	1
5925	RB1	3
4893	NRAS	1
1209	CLPTM1	3
5324	PLAG1	3
862	RUNX1T1	2
8717	TRADD	3
2308	FOXO1	1
2534	FYN	2
2258	FGF13	3
8841	HDAC3	2
5586	PKN2	2
4205	MEF2A	4
3488	IGFBP5	2
3480	IGF1R	3
23092	ARHGAP26	3
4299	AFF1	2
2651	GCNT2	2
2261	FGFR3	3
865	CBFB	3
2073	ERCC5	3
581	BAX	3
79966	SCD5	3
55746	NUP133	3
8814	CDKL1	1
55791	LRIF1	1
4613	MYCN	3
1840	DTX1	3
4286	MITF	3
57096	RPGRIP1	3
23683	PRKD3	3
1608	DGKG	1
699	BUB1	2
7294	TXK	2
6868	ADAM17	1
27255	CNTN6	2
3895	KTN1	2
3440	IFNA2	1
2892	GRIA3	2
1436	CSF1R	3
1795	DOCK3	3
5970	RELA	1

Gene in drug-gene network: Network Plot

Models in Serdemetan

SITE

DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.