CNTN6
Summary: The protein encoded by this gene is a member of the immunoglobulin superfamily. It is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein that functions as a cell adhesion molecule. It may play a role in the formation of axon connections in the developing nervous system. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| contactin 6 | MIM:607220 | Ensembl:ENSG00000134115 | HGNC:HGNC:2176 | PA26690 | 3p26.3 |
GO terms in CNTN6
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IEA | GO:0005886 | plasma membrane |
| CC | IEA | GO:0031225 | anchored component of membrane |
| BP | IEA | GO:0007155 | cell adhesion |
| BP | IEA | GO:0007219 | Notch signaling pathway |
| BP | TAS | GO:0007417 | central nervous system development |
| BP | IEA | GO:0030182 | neuron differentiation |
| BP | IEA | GO:0045747 | positive regulation of Notch signaling pathway |
| MF | IEA | GO:0005112 | Notch binding |
Gene expression in normal tissue: CNTN6
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CNTN6
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-373760 | L1CAM interactions |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-447041 | CHL1 interactions |
| pid | notch_pathway | Notch signaling pathway |
| wikipathways | WP3651 | Pathways Affected in Adenoid Cystic Carcinoma |
| wikipathways | WP3845 | Canonical and Non-canonical Notch signaling |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD85 | Ursolic acid | 2 |
| iGMDRD351 | GW843682X | 5 |
| iGMDRD901 | ELCPK | 5 |
| iGMDRD123 | Isoevodiamine | 2 |
| iGMDRD177 | Teniposide | 2 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 3 |
| iGMDRD945 | ML214 | 8 |
| iGMDRD84 | Lovastatin acid | 3 |
| iGMDRD424 | Tamatinib | 3 |
| iGMDRD523 | Cyanoquinoline, 11 | 3 |
| iGMDRD414 | MST-312 | 3 |
| iGMDRD286 | Nsc 632839 | 2 |
| iGMDRD872 | BRD7137 | 2 |
| iGMDRD662 | JQ-1 | 3 |
| iGMDRD886 | Compound 1541A | 3 |
| iGMDRD263 | AACOCF3 | 1 |
| iGMDRD246 | NPC26 | 4 |
| iGMDRD322 | FK 866 | 4 |
| iGMDRD103 | SN-38 | 4 |
| iGMDRD137 | Indisulam | 2 |
| iGMDRD202 | Curcumin | 3 |
| iGMDRD121 | GMX1778 | 4 |
| iGMDRD5 | Tyrphostin AG 1478 | 2 |
| iGMDRD379 | BIBR-1532 | 3 |
| iGMDRD705 | Nakiterpiosin | 2 |
| iGMDRD289 | Parthenolide | 4 |
| iGMDRD481 | Dactolisib | 1 |
| iGMDRD231 | Importazole | 1 |
| iGMDRD77 | Itraconazole | 5 |
| iGMDRD446 | LY 2183240 | 2 |
| iGMDRD639 | YK 4-279 | 3 |
| iGMDRD152 | 179324-69-7 | 1 |
| iGMDRD193 | Fqi1 | 2 |
| iGMDRD61 | Kinetin riboside | 3 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
| iGMDRD466 | Chaetocin | 3 |
| iGMDRD634 | SCHEMBL2608041 | 3 |
| iGMDRD151 | CHM-1 | 2 |
| iGMDRD1008 | SR-II-138A | 2 |
| iGMDRD420 | Leucascandrolide A | 2 |
| iGMDRD772 | BRD4770 | 2 |
| iGMDRD779 | PRL-3 Inhibitor I | 4 |
| iGMDRD546 | BMS-754807 | 2 |
| iGMDRD427 | ABT737 | 1 |
| iGMDRD188 | Piperlongumine | 2 |
| iGMDRD74 | Idarubicin | 4 |
| iGMDRD506 | Fedratinib | 3 |
| iGMDRD562 | Navitoclax | 2 |
| iGMDRD780 | PP-30 | 1 |
| iGMDRD64 | Parbendazole | 3 |
| iGMDRD874 | BRD8958 | 1 |
| iGMDRD451 | Serdemetan | 2 |
| iGMDRD270 | Ciclosporin | 2 |
| iGMDRD138 | PX 12 | 1 |
| iGMDRD802 | 4-methylfasudil | 4 |
| iGMDRD171 | Pemetrexed | 2 |
| iGMDRD441 | TW 37 | 2 |
| iGMDRD870 | BRD63610 | 2 |
| iGMDRD52 | Rotenone | 2 |
| iGMDRD294 | Batimastat | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CNTN6
CLASSFICATION
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