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iGMDRD52

Canonical SMILES: CC(=C)C1CC2=C(O1)C=CC3=C2OC4COC5=CC(=C(C=C5C4C3=O)OC)OC

InChI: InChI=1S/C23H22O6/c1-11(2)16-8-14-15(28-16)6-5-12-22(24)21-13-7-18(25-3)19(26-4)9-17(13)27-10-20(21)29-23(12)14/h5-7,9,16,20-21H,1,8,10H2,2-4H3/t16-,20-,21+/m1/s1

InChI Key: JUVIOZPCNVVQFO-HBGVWJBISA-N

Standard Name	CHEMBL	Pubchem CID	DRUGBANK ID	Drug Status	Drug Type
Rotenone	CHEMBL429023	6758	DB11457	Alone	Small Molecule

Drug Class:

Agrochemicals Benzopyrans Chromones Enzyme Inhibitors Flavonoids Heterocyclic Compounds Heterocyclic Compounds with 4 or More Rings Heterocyclic Compounds, 1-Ring Heterocyclic Compounds, 2-Ring Insecticides Isoflavones Pesticides Pyrans Specialty Uses of Chemicals Toxic Actions Uncoupling Agents

Drug Pathways:

Isoflavonoid biosynthesis Biosynthesis of phenylpropanoids Biosynthesis of secondary metabolites Parkinson disease

Drug-model tissue-cancer distribution: Bubble Plot

Drug-gene pathway enrichments

Drug-gene GO enrichments

Drug-Gene: Aster Plot

Gene ID	Gene Name	Model Num.
331	XIAP	3
9833	MELK	1
7074	TIAM1	2
10903	MTMR11	2
79054	TRPM8	2
21	ABCA3	3
3383	ICAM1	3
7161	TP73	3
4926	NUMA1	2
57679	ALS2	3
2339	FNTA	3
4477	MSMB	3
9706	ULK2	3
3845	KRAS	3
6563	SLC14A1	2
2100	ESR2	3
8289	ARID1A	2
80070	ADAMTS20	1
5934	RBL2	2
25778	DSTYK	1
79092	CARD14	2
6597	SMARCA4	2
4036	LRP2	3
5133	PDCD1	2
843	CASP10	3
11116	FGFR1OP	1
79820	CATSPERB	2
390502	SERPINA2	2
4313	MMP2	4
1786	DNMT1	1
1607	DGKB	2
3694	ITGB6	2
55781	RIOK2	6
27	ABL2	3
51199	NIN	1
114783	LMTK3	2
112858	TP53RK	2
5756	TWF1	1
2043	EPHA4	4
5467	PPARD	2
5788	PTPRC	2
56164	STK31	2
5579	PRKCB	2
11200	CHEK2	3
10178	TENM1	2
9411	ARHGAP29	7
2977	GUCY1A2	6
5159	PDGFRB	3
10215	OLIG2	3
7158	TP53BP1	2
2033	EP300	1
6927	HNF1A	4
641	BLM	3
64324	NSD1	3
23522	KAT6B	5
816	CAMK2B	5
55819	RNF130	3
152137	CCDC50	2
8767	RIPK2	6
122011	CSNK1A1L	2
2051	EPHB6	2
222484	LNX2	3
3714	JAG2	2
3556	IL1RAP	2
5613	PRKX	3
26353	HSPB8	3
6041	RNASEL	2
200576	PIKFYVE	6
116986	AGAP2	4
199699	DAND5	3
23255	MTCL1	2
9636	ISG15	6
2736	GLI2	5
29904	EEF2K	3
7088	TLE1	2
2045	EPHA7	4
7016	TESK1	3
238	ALK	2
171019	ADAMTS19	3
2064	ERBB2	3
85443	DCLK3	3
65266	WNK4	2
65217	PCDH15	1
8395	PIP5K1B	1
79971	WLS	2
23387	SIK3	2
1456	CSNK1G3	6
6416	MAP2K4	4
9759	HDAC4	1
92	ACVR2A	2
10087	COL4A3BP	3
6464	SHC1	4
6098	ROS1	3
9472	AKAP6	5
157285	PRAG1	1
130497	OSR1	3
472	ATM	2
8945	BTRC	4
139285	AMER1	7
84433	CARD11	1
9564	BCAR1	2
4058	LTK	2
5289	PIK3C3	2
2272	FHIT	3
2066	ERBB4	2
2201	FBN2	2
7184	HSP90B1	2
27436	EML4	4
57523	NYNRIN	9
83694	RPS6KL1	3
5336	PLCG2	1
9874	TLK1	3
28514	DLL1	4
7157	TP53	2
6092	ROBO2	6
4602	MYB	2
6794	STK11	6
4857	NOVA1	6
5910	RAP1GDS1	6
3791	KDR	3
6184	RPN1	1
7249	TSC2	1
1019	CDK4	1
65243	ZFP69B	2
105	ADARB2	2
85481	PSKH2	3
5604	MAP2K1	3
1102	RCBTB2	1
55437	STRADB	2
2309	FOXO3	2
7038	TG	1
57188	ADAMTSL3	2
136332	LRGUK	3
4436	MSH2	2
1656	DDX6	2
80205	CHD9	4
2000	ELF4	6
3718	JAK3	3
57578	UNC79	5
4026	LPP	3
6654	SOS1	2
10948	STARD3	3
1848	DUSP6	3
9252	RPS6KA5	2
10733	PLK4	3
78989	COLEC11	5
23373	CRTC1	5
9448	MAP4K4	3
285220	EPHA6	5
546	ATRX	1
3417	IDH1	1
5297	PI4KA	4
10926	DBF4	2
10535	RNASEH2A	3
30827	CXXC1	3
340533	NEXMIF	3
5290	PIK3CA	2
5034	P4HB	2
1000	CDH2	2
253260	RICTOR	1
7043	TGFB3	6
57154	SMURF1	2
7075	TIE1	2
744	MPPED2	1
1956	EGFR	4
8445	DYRK2	4
4609	MYC	1
2624	GATA2	2
5789	PTPRD	2
90427	BMF	2
283629	TSSK4	3
79759	ZNF668	3
2189	FANCG	3
204851	HIPK1	4
3635	INPP5D	4
27330	RPS6KA6	6
6011	GRK1	4
1769	DNAH8	3
22976	PAXIP1	3
23532	PRAME	2
57538	ALPK3	3
339345	NANOS2	3
120892	LRRK2	2
7027	TFDP1	6
5979	RET	3
9451	EIF2AK3	2
9843	HEPH	3
9509	ADAMTS2	2
5563	PRKAA2	2
23742	NPAP1	2
7155	TOP2B	4
80124	VCPIP1	6
667	DST	2
115701	ALPK2	5
3554	IL1R1	3
2897	GRIK1	3
28954	REM1	6
79834	PEAK1	1
7454	WAS	2
10257	ABCC4	1
85415	RHPN2	5
55359	STYK1	3
2277	VEGFD	2
29959	NRBP1	2
8648	NCOA1	3
22843	PPM1E	1
57820	CCNB1IP1	3
23305	ACSL6	2
1643	DDB2	2
54738	FEV	3
558	AXL	1
57680	CHD8	3
5923	RASGRF1	1
2690	GHR	2
9201	DCLK1	2
5335	PLCG1	2
5587	PRKD1	4
55007	FAM118A	2
5170	PDPK1	1
1975	EIF4B	6
22982	DIP2C	1
79837	PIP4K2C	2
3709	ITPR2	1
1030	CDKN2B	2
3984	LIMK1	2
444	ASPH	2
2122	MECOM	1
3815	KIT	3
4893	NRAS	1
8661	EIF3A	1
7403	KDM6A	1
255239	ANKK1	5
4205	MEF2A	3
30849	PIK3R4	4
3716	JAK1	2
2011	MARK2	2
51135	IRAK4	2
11086	ADAM29	2
2073	ERCC5	3
4040	LRP6	3
4841	NONO	6
4763	NF1	4
55791	LRIF1	2
2044	EPHA5	2
814	CAMK4	1
10048	RANBP9	2
1608	DGKG	1
27255	CNTN6	2
83732	RIOK1	3
56155	TEX14	5
2892	GRIA3	5
2886	GRB7	1

Gene in drug-gene network: Network Plot

Models in Rotenone

SITE

DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.