ARHGAP29
Summary: Rap1 is a small GTPase that, through effectors, regulates Rho GTPase signaling. These effectors- Rasip1, Radil, and the protein encoded by this gene- translocate to the cell membrane, where they form a multiprotein complex. This complex is necessary for Rap1-induced inhibition of Rho signaling. Defects in this gene may be a cause of nonsyndromic cleft lip with or without cleft palate. [provided by RefSeq, Jun 2016].
Loading, please wait...
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:610496 Ensembl IDEnsembl:ENSG00000137962 HGNC IDHGNC:HGNC:30207 PHARMGKB IDPA128394548 Map Location1p22.1 | |||||
GO terms in ARHGAP29
Loading, please wait...
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0005096 | GTPase activator activity |
| MF | IDA | GO:0030165 | PDZ domain binding |
| MF | IEA | GO:0046872 | metal ion binding |
| BP | TAS | GO:0007266 | Rho protein signal transduction |
| BP | IEA | GO:0043547 | positive regulation of GTPase activity |
| BP | TAS | GO:0051056 | regulation of small GTPase mediated signal transduction |
Gene expression in normal tissue: ARHGAP29
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ARHGAP29
Loading, please wait...
Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP3655 | Hypothetical Craniofacial Development Pathway |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-194315 | Signaling by Rho GTPases |
| reactome | R-HSA-194840 | Rho GTPase cycle |
Showing 1 to 4 of 4 rows
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ARHGAP29
Loading, please wait...
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.