ARHGAP29


Summary: Rap1 is a small GTPase that, through effectors, regulates Rho GTPase signaling. These effectors- Rasip1, Radil, and the protein encoded by this gene- translocate to the cell membrane, where they form a multiprotein complex. This complex is necessary for Rap1-induced inhibition of Rho signaling. Defects in this gene may be a cause of nonsyndromic cleft lip with or without cleft palate. [provided by RefSeq, Jun 2016].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
Rho GTPase activating protein 29MIM:610496Ensembl:ENSG00000137962HGNC:HGNC:30207PA1283945481p22.1

GO terms in ARHGAP29


Term TypeEvidence TypeGO Term IDGO Des.
MFTASGO:0005096GTPase activator activity
MFIDAGO:0030165PDZ domain binding
MFIEAGO:0046872metal ion binding
BPTASGO:0007266Rho protein signal transduction
BPIEAGO:0043547positive regulation of GTPase activity
BPTASGO:0051056regulation of small GTPase mediated signal transduction
CCIDAGO:0005737cytoplasm
CCTASGO:0005829cytosol

Gene expression in normal tissue: ARHGAP29

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ARHGAP29


DatabasePathway IDPathway Des.
wikipathwaysWP3655Hypothetical Craniofacial Development Pathway
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-194315Signaling by Rho GTPases
reactomeR-HSA-194840Rho GTPase cycle

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD52Rotenone7
iGMDRD8012,4-dideoxy-DC-45-A22
iGMDRD782DC-45-A27
iGMDRD171Pemetrexed4
iGMDRD451Serdemetan2
iGMDRD23Gossypol5
iGMDRD60Quinoclamine3
iGMDRD780PP-304
iGMDRD398Sepantronium2
iGMDRD562Navitoclax9
iGMDRD188Piperlongumine2
iGMDRD781Sirolimus1
iGMDRD494Neopeltolide4
iGMDRD670ML 2103
iGMDRD427ABT7372
iGMDRD420Leucascandrolide A2
iGMDRD599Salermide3
iGMDRD126Tipifarnib4
iGMDRD634SCHEMBL26080412
iGMDRD466Chaetocin4
iGMDRD280CYTOCHALASIN B2
iGMDRD152179324-69-74
iGMDRD267Oligomycin A2
iGMDRD504Obatoclax1
iGMDRD289Parthenolide4
iGMDRD105Triptolide2
iGMDRD251ML1622
iGMDRD322FK 8662
iGMDRD886Compound 1541A4
iGMDRD329Merck603
iGMDRD286Nsc 6328396
iGMDRD414MST-3128
iGMDRD523Cyanoquinoline, 111
iGMDRD116CD4372
iGMDRD512nutlin 33
iGMDRD330BRD41325
iGMDRD132(-)-gallocatechin-3-O-gallate3
iGMDRD177Teniposide4
iGMDRD85Ursolic acid2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ARHGAP29

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