ARHGAP29
Summary: Rap1 is a small GTPase that, through effectors, regulates Rho GTPase signaling. These effectors- Rasip1, Radil, and the protein encoded by this gene- translocate to the cell membrane, where they form a multiprotein complex. This complex is necessary for Rap1-induced inhibition of Rho signaling. Defects in this gene may be a cause of nonsyndromic cleft lip with or without cleft palate. [provided by RefSeq, Jun 2016].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| Rho GTPase activating protein 29 | MIM:610496 | Ensembl:ENSG00000137962 | HGNC:HGNC:30207 | PA128394548 | 1p22.1 |
GO terms in ARHGAP29
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0005096 | GTPase activator activity |
| MF | IDA | GO:0030165 | PDZ domain binding |
| MF | IEA | GO:0046872 | metal ion binding |
| BP | TAS | GO:0007266 | Rho protein signal transduction |
| BP | IEA | GO:0043547 | positive regulation of GTPase activity |
| BP | TAS | GO:0051056 | regulation of small GTPase mediated signal transduction |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005829 | cytosol |
Gene expression in normal tissue: ARHGAP29
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ARHGAP29
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP3655 | Hypothetical Craniofacial Development Pathway |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-194315 | Signaling by Rho GTPases |
| reactome | R-HSA-194840 | Rho GTPase cycle |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD52 | Rotenone | 7 |
| iGMDRD801 | 2,4-dideoxy-DC-45-A2 | 2 |
| iGMDRD782 | DC-45-A2 | 7 |
| iGMDRD171 | Pemetrexed | 4 |
| iGMDRD451 | Serdemetan | 2 |
| iGMDRD23 | Gossypol | 5 |
| iGMDRD60 | Quinoclamine | 3 |
| iGMDRD780 | PP-30 | 4 |
| iGMDRD398 | Sepantronium | 2 |
| iGMDRD562 | Navitoclax | 9 |
| iGMDRD188 | Piperlongumine | 2 |
| iGMDRD781 | Sirolimus | 1 |
| iGMDRD494 | Neopeltolide | 4 |
| iGMDRD670 | ML 210 | 3 |
| iGMDRD427 | ABT737 | 2 |
| iGMDRD420 | Leucascandrolide A | 2 |
| iGMDRD599 | Salermide | 3 |
| iGMDRD126 | Tipifarnib | 4 |
| iGMDRD634 | SCHEMBL2608041 | 2 |
| iGMDRD466 | Chaetocin | 4 |
| iGMDRD280 | CYTOCHALASIN B | 2 |
| iGMDRD152 | 179324-69-7 | 4 |
| iGMDRD267 | Oligomycin A | 2 |
| iGMDRD504 | Obatoclax | 1 |
| iGMDRD289 | Parthenolide | 4 |
| iGMDRD105 | Triptolide | 2 |
| iGMDRD251 | ML162 | 2 |
| iGMDRD322 | FK 866 | 2 |
| iGMDRD886 | Compound 1541A | 4 |
| iGMDRD329 | Merck60 | 3 |
| iGMDRD286 | Nsc 632839 | 6 |
| iGMDRD414 | MST-312 | 8 |
| iGMDRD523 | Cyanoquinoline, 11 | 1 |
| iGMDRD116 | CD437 | 2 |
| iGMDRD512 | nutlin 3 | 3 |
| iGMDRD330 | BRD4132 | 5 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 3 |
| iGMDRD177 | Teniposide | 4 |
| iGMDRD85 | Ursolic acid | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ARHGAP29
CLASSFICATION
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