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iGMDRD188

Canonical SMILES: COC1=CC(=CC(=C1OC)OC)C=CC(=O)N2CCC=CC2=O

InChI: InChI=1S/C17H19NO5/c1-21-13-10-12(11-14(22-2)17(13)23-3)7-8-16(20)18-9-5-4-6-15(18)19/h4,6-8,10-11H,5,9H2,1-3H3/b8-7+

InChI Key: VABYUUZNAVQNPG-BQYQJAHWSA-N

Standard Name	CHEMBL	Pubchem CID	Drug Status	Drug Type
Piperlongumine	CHEMBL465843	637858	Alone	Small Molecule

Drug Targets:

Increases ROS levels

Drug-model tissue-cancer distribution: Bubble Plot

Drug-gene pathway enrichments

Drug-gene GO enrichments

Drug-Gene: Aster Plot

Gene ID	Gene Name	Model Num.
331	XIAP	2
3696	ITGB8	3
64901	RANBP17	2
1147	CHUK	3
1105	CHD1	5
9833	MELK	1
27125	AFF4	3
7514	XPO1	1
8999	CDKL2	4
6664	SOX11	3
8019	BRD3	1
81037	CLPTM1L	4
5027	P2RX7	3
10903	MTMR11	3
997	CDC34	3
471	ATIC	2
79848	CSPP1	4
7837	PXDN	2
79054	TRPM8	3
10221	TRIB1	3
1464	CSPG4	2
10641	NPRL2	6
23085	ERC1	8
6491	STIL	2
5261	PHKG2	6
8444	DYRK3	5
10987	COPS5	9
9261	MAPKAPK2	2
21	ABCA3	6
3383	ICAM1	3
7421	VDR	3
8476	CDC42BPA	2
7750	ZMYM2	6
11183	MAP4K5	2
5546	PRCC	2
10806	SDCCAG8	2
2956	MSH6	2
2200	FBN1	1
26286	ARFGAP3	1
55872	PBK	3
57679	ALS2	2
150465	TTL	4
3708	ITPR1	3
1969	EPHA2	3
9706	ULK2	2
9149	DYRK1B	4
7272	TTK	3
3845	KRAS	2
3757	KCNH2	2
51347	TAOK3	3
4750	NEK1	2
8289	ARID1A	4
80070	ADAMTS20	3
701	BUB1B	6
51231	VRK3	3
5934	RBL2	2
2335	FN1	6
5593	PRKG2	3
53616	ADAM22	2
3431	SP110	5
6938	TCF12	4
2475	MTOR	5
1263	PLK3	3
9475	ROCK2	3
6597	SMARCA4	3
150209	AIFM3	1
9869	SETDB1	2
11160	ERLIN2	1
10395	DLC1	1
5133	PDCD1	2
3069	HDLBP	2
11116	FGFR1OP	8
10320	IKZF1	2
3209	HOXA13	1
79820	CATSPERB	3
7444	VRK2	6
7942	TFEB	1
390502	SERPINA2	8
53944	CSNK1G1	6
5754	PTK7	4
56776	FMN2	2
64783	RBM15	5
51684	SUFU	8
10892	MALT1	10
23235	SIK2	4
10863	ADAM28	3
6598	SMARCB1	5
9891	NUAK1	2
1136	CHRNA3	3
1607	DGKB	8
3320	HSP90AA1	1
3066	HDAC2	11
10142	AKAP9	1
55781	RIOK2	3
23310	NCAPD3	5
7098	TLR3	6
5298	PI4KB	3
8749	ADAM18	4
3841	KPNA5	2
2241	FER	6
55534	MAML3	2
22821	RASA3	4
140469	MYO3B	2
79934	COQ8B	7
54822	TRPM7	3
7080	NKX2-1	1
28231	SLCO4A1	2
114783	LMTK3	2
202374	STK32A	2
1387	CREBBP	1
1893	ECM1	3
5756	TWF1	1
10454	TAB1	3
3727	JUND	3
127933	UHMK1	2
2885	GRB2	3
5788	PTPRC	5
23225	NUP210	2
56164	STK31	2
4283	CXCL9	3
10013	HDAC6	5
5579	PRKCB	2
31	ACACA	5
7133	TNFRSF1B	2
79858	NEK11	2
5966	REL	3
9411	ARHGAP29	2
85021	REPS1	2
3604	TNFRSF9	2
29998	BICRA	2
1111	CHEK1	4
2977	GUCY1A2	9
10438	C1D	4
11122	PTPRT	6
23617	TSSK2	2
9024	BRSK2	3
5396	PRRX1	3
5159	PDGFRB	4
7373	COL14A1	2
5166	PDK4	2
7173	TPO	4
10215	OLIG2	6
2120	ETV6	1
5314	PKHD1	4
139378	ADGRG4	2
145264	SERPINA12	3
55294	FBXW7	2
10295	BCKDK	3
2033	EP300	4
6927	HNF1A	2
8784	TNFRSF18	4
8030	CCDC6	3
9578	CDC42BPB	2
641	BLM	3
4595	MUTYH	1
1453	CSNK1D	5
10818	FRS2	1
54477	PLEKHA5	3
57670	KIAA1549	6
22861	NLRP1	2
440279	UNC13C	2
4610	MYCL	9
4301	AFDN	5
816	CAMK2B	5
5081	PAX7	3
55819	RNF130	3
84033	OBSCN	2
51776	MAP3K20	2
342977	NANOS3	3
256646	NUTM1	2
131096	KCNH8	2
388228	SBK1	3
7025	NR2F1	2
23012	STK38L	4
57787	MARK4	4
4478	MSN	1
1586	CYP17A1	4
6256	RXRA	1
1591	CYP24A1	4
32	ACACB	3
8852	AKAP4	1
3556	IL1RAP	3
5613	PRKX	9
329	BIRC2	2
2688	GH1	6
4005	LMO2	1
22984	PDCD11	4
6041	RNASEL	3
80351	TNKS2	5
8313	AXIN2	5
6733	SRPK2	3
6091	ROBO1	4
1050	CEBPA	1
2260	FGFR1	6
5330	PLCB2	3
730249	ACOD1	3
10188	TNK2	5
4216	MAP3K4	3
2736	GLI2	3
29904	EEF2K	1
83990	BRIP1	4
51804	SIX4	4
4739	NEDD9	3
9098	USP6	2
4194	MDM4	2
1984	EIF5A	3
7088	TLE1	2
388581	C1QTNF12	3
55681	SCYL2	3
4982	TNFRSF11B	2
2045	EPHA7	2
238	ALK	2
1277	COL1A1	2
7078	TIMP3	4
375449	MAST4	6
2064	ERBB2	5
983	CDK1	3
85443	DCLK3	2
287015	TRIM42	2
57476	GRAMD1B	2
83983	TSSK6	5
65217	PCDH15	7
8395	PIP5K1B	5
6663	SOX10	3
993	CDC25A	3
54899	PXK	3
7486	WRN	5
440730	TRIM67	1
23387	SIK3	1
4294	MAP3K10	3
1456	CSNK1G3	5
783	CACNB2	6
9759	HDAC4	3
92	ACVR2A	2
10400	PEMT	5
5286	PIK3C2A	3
64170	CARD9	3
6709	SPTAN1	4
8215	DVL1P1	2
1973	EIF4A1	3
158056	MAMDC4	3
50488	MINK1	6
2068	ERCC2	2
5591	PRKDC	3
5568	PRKACG	3
6464	SHC1	4
659	BMPR2	4
6037	RNASE3	1
6098	ROS1	1
8515	ITGA10	3
124923	SGK494	3
2778	GNAS	6
6917	TCEA1	6
472	ATM	5
8945	BTRC	7
5165	PDK3	3
1009	CDH11	9
83903	HASPIN	3
28996	HIPK2	2
575	ADGRB1	5
53942	CNTN5	2
5924	RASGRF2	3
2734	GLG1	2
84433	CARD11	4
9564	BCAR1	5
4804	NGFR	6
4058	LTK	2
6792	CDKL5	7
1123	CHN1	4
7010	TEK	1
5450	POU2AF1	3
898	CCNE1	2
23152	CIC	2
2050	EPHB4	1
2272	FHIT	2
7867	MAPKAPK3	3
2066	ERBB4	2
8798	DYRK4	3
904	CCNT1	3
1647	GADD45A	3
28951	TRIB2	3
5327	PLAT	2
5863	RGL2	5
51517	NCKIPSD	3
9319	TRIP13	2
79442	LRRC2	3
10413	YAP1	9
2201	FBN2	2
1029	CDKN2A	2
7184	HSP90B1	2
5108	PCM1	3
9794	MAML1	3
5129	CDK18	2
23048	FNBP1	2
27436	EML4	4
157753	TMEM74	3
57523	NYNRIN	4
8576	STK16	3
1910	EDNRB	3
3236	HOXD10	4
5336	PLCG2	4
9874	TLK1	3
11143	KAT7	2
28514	DLL1	3
3932	LCK	3
58508	KMT2C	1
7157	TP53	2
2099	ESR1	2
6092	ROBO2	9
7704	ZBTB16	3
79058	ASPSCR1	2
4855	NOTCH4	2
6794	STK11	6
2322	FLT3	2
57194	ATP10A	6
25836	NIPBL	7
7869	SEMA3B	5
8218	CLTCL1	9
57410	SCYL1	2
3791	KDR	1
7170	TPM3	2
2329	FMO4	1
356	FASLG	3
4292	MLH1	5
93210	PGAP3	4
6184	RPN1	3
54498	SMOX	2
2263	FGFR2	6
4086	SMAD1	1
106480993	RN7SL263P	3
5585	PKN1	3
7249	TSC2	4
7409	VAV1	3
65243	ZFP69B	5
1045	CDX2	3
105	ADARB2	2
85481	PSKH2	6
8833	GMPS	3
64386	MMP25	1
344387	CDKL4	4
863	CBFA2T3	5
1555	CYP2B6	4
5600	MAPK11	1
55437	STRADB	2
4921	DDR2	4
3572	IL6ST	5
5077	PAX3	2
6197	RPS6KA3	8
55589	BMP2K	3
65125	WNK1	5
136332	LRGUK	3
4436	MSH2	3
652	BMP4	3
6035	RNASE1	3
1656	DDX6	3
1441	CSF3R	3
5650	KLK7	3
7175	TPR	7
5871	MAP4K2	9
80205	CHD9	6
84181	CHD6	6
57578	UNC79	5
8997	KALRN	6
23269	MGA	1
6280	S100A9	2
5371	PML	6
23469	PHF3	5
4089	SMAD4	1
51284	TLR7	3
54658	UGT1A1	1
6654	SOS1	7
11168	PSIP1	3
1848	DUSP6	7
2737	GLI3	2
4139	MARK1	1
7204	TRIO	2
23373	CRTC1	2
5727	PTCH1	5
9448	MAP4K4	2
285220	EPHA6	2
546	ATRX	3
51366	UBR5	2
85414	SLC45A3	6
5297	PI4KA	2
501	ALDH7A1	5
7786	MAP3K12	6
10769	PLK2	2
64840	PORCN	3
56997	COQ8A	6
340533	NEXMIF	2
3702	ITK	5
9972	NUP153	8
3239	HOXD13	9
5290	PIK3CA	4
3562	IL3	3
92335	STRADA	2
3720	JARID2	4
1514	CTSL	5
5034	P4HB	8
4145	MATK	6
1687	GSDME	2
8202	NCOA3	1
79987	SVEP1	1
7043	TGFB3	4
85366	MYLK2	3
2318	FLNC	4
10565	ARFGEF1	2
64919	BCL11B	6
57154	SMURF1	4
5530	PPP3CA	3
675	BRCA2	4
26166	RGS22	2
607	BCL9	5
7075	TIE1	6
1956	EGFR	4
640	BLK	5
157680	VPS13B	5
841	CASP8	4
3065	HDAC1	6
64333	ARHGAP9	7
64750	SMURF2	3
2624	GATA2	4
3308	HSPA4	6
5789	PTPRD	3
5155	PDGFB	4
1459	CSNK2A2	4
8013	NR4A3	3
10461	MERTK	6
100130933	SMIM6	3
7297	TYK2	3
26278	SACS	4
894	CCND2	4
5462	POU5F1B	1
896	CCND3	2
6446	SGK1	1
79759	ZNF668	2
5592	PRKG1	8
1594	CYP27B1	2
5747	PTK2	1
5156	PDGFRA	3
7443	VRK1	4
3635	INPP5D	5
1653	DDX1	2
5187	PER1	5
375056	MIA3	4
10000	AKT3	2
93627	TBCK	5
137872	ADHFE1	3
27330	RPS6KA6	3
7132	TNFRSF1A	3
7189	TRAF6	1
56924	PAK6	2
23005	MAPKBP1	6
673	BRAF	1
7153	TOP2A	5
84630	TTBK1	4
1981	EIF4G1	3
1213	CLTC	3
4790	NFKB1	3
84879	MFSD2A	10
1769	DNAH8	2
22976	PAXIP1	4
3315	HSPB1	3
23532	PRAME	9
4863	NPAT	5
83452	RAB33B	4
8924	HERC2	2
2078	ERG	8
6469	SHH	1
120892	LRRK2	5
65268	WNK2	4
79184	BRCC3	2
7027	TFDP1	3
6095	RORA	6
146057	TTBK2	3
57507	ZNF608	2
84441	MAML2	3
7301	TYRO3	3
7468	NSD2	2
8029	CUBN	3
23118	TAB2	3
8626	TP63	1
9113	LATS1	5
460	ASTN1	5
9064	MAP3K6	2
5294	PIK3CG	3
7849	PAX8	3
5979	RET	1
9321	TRIP11	2
10253	SPRY2	6
9451	EIF2AK3	6
8491	MAP4K3	2
1230	CCR1	1
157	GRK3	2
266747	RGL4	3
3229	HOXC13	3
5563	PRKAA2	7
23396	PIP5K1C	2
10010	TANK	3
8312	AXIN1	5
10752	CHL1	2
5728	PTEN	2
57521	RPTOR	5
208	AKT2	6
51330	TNFRSF12A	3
1487	CTBP1	3
7030	TFE3	2
7155	TOP2B	3
1869	E2F1	1
80124	VCPIP1	3
4914	NTRK1	2
22883	CLSTN1	2
667	DST	4
23281	MTUS2	3
1974	EIF4A2	2
115701	ALPK2	2
660	BMX	3
3554	IL1R1	3
1613	DAPK3	3
2897	GRIK1	5
352909	DNAAF3	2
6146	RPL22	1
2324	FLT4	2
3678	ITGA5	4
9344	TAOK2	2
8301	PICALM	6
3899	AFF3	2
7273	TTN	2
91807	MYLK3	2
79834	PEAK1	3
7465	WEE1	3
7454	WAS	4
10257	ABCC4	2
85415	RHPN2	2
23389	MED13L	3
8667	EIF3H	6
54904	NSD3	2
23411	SIRT1	5
53904	MYO3A	1
29941	PKN3	5
3161	HMMR	2
9372	ZFYVE9	5
55561	CDC42BPG	2
2046	EPHA8	3
80184	CEP290	1
8821	INPP4B	2
84930	MASTL	2
8805	TRIM24	1
5532	PPP3CB	4
8394	PIP5K1A	2
2353	FOS	3
286151	FBXO43	3
10595	ERN2	2
344905	ATP13A5	3
5588	PRKCQ	3
5291	PIK3CB	3
558	AXL	1
7248	TSC1	2
126792	B3GALT6	2
4619	MYH1	5
332	BIRC5	4
57680	CHD8	2
3297	HSF1	3
5581	PRKCE	2
5923	RASGRF1	2
1399	CRKL	4
2690	GHR	2
2317	FLNB	6
10111	RAD50	4
100124696	TEC	3
9223	MAGI1	3
5395	PMS2	3
1789	DNMT3B	2
55289	ACOXL	6
152110	NEK10	1
1281	COL3A1	2
9659	PDE4DIP	2
63976	PRDM16	2
7293	TNFRSF4	4
2049	EPHB3	3
5927	KDM5A	6
598	BCL2L1	3
3579	CXCR2	3
63967	CLSPN	1
5583	PRKCH	3
10734	STAG3	3
5170	PDPK1	6
2321	FLT1	2
57448	BIRC6	4
2131	EXT1	3
57007	ACKR3	1
2304	FOXE1	8
23139	MAST2	4
7099	TLR4	3
2157	F8	4
53335	BCL11A	4
79837	PIP4K2C	4
3709	ITPR2	4
57147	SCYL3	3
6778	STAT6	1
11040	PIM2	2
8899	PRPF4B	3
4067	LYN	2
65267	WNK3	4
84254	CAMKK1	3
3984	LIMK1	2
8428	STK24	3
51562	MBIP	2
3516	RBPJ	5
6777	STAT5B	3
3552	IL1A	5
5932	RBBP8	2
3977	LIFR	6
84072	HORMAD1	3
444	ASPH	3
11076	TPPP	2
7913	DEK	3
2122	MECOM	5
3662	IRF4	2
51167	CYB5R4	3
1760	DMPK	2
5087	PBX1	2
9212	AURKB	4
2903	GRIN2A	5
4974	OMG	5
5925	RB1	7
4893	NRAS	2
1209	CLPTM1	2
1026	CDKN1A	2
2065	ERBB3	3
2074	ERCC6	2
5324	PLAG1	2
862	RUNX1T1	4
10420	TESK2	2
7403	KDM6A	4
2308	FOXO1	1
81629	TSSK3	3
7508	XPC	3
4615	MYD88	3
2258	FGF13	3
4302	MLLT6	3
4638	MYLK	5
255239	ANKK1	3
5586	PKN2	3
4205	MEF2A	3
7040	TGFB1	10
3716	JAK1	4
3488	IGFBP5	5
3480	IGF1R	3
2011	MARK2	2
10494	STK25	1
2651	GCNT2	2
11086	ADAM29	3
374	AREG	3
2261	FGFR3	8
139604	MAGEB16	2
5567	PRKACB	3
8711	TNK1	6
4040	LRP6	3
84446	BRSK1	3
55422	ZNF331	6
55746	NUP133	1
8814	CDKL1	3
57697	FANCM	3
5260	PHKG1	1
9625	AATK	3
1994	ELAVL1	5
63893	UBE2O	4
1840	DTX1	2
65975	STK33	2
4591	TRIM37	4
10891	PPARGC1A	1
440270	GOLGA8B	1
5288	PIK3C2G	4
57096	RPGRIP1	3
4629	MYH11	3
23683	PRKD3	2
3679	ITGA7	4
10048	RANBP9	2
4780	NFE2L2	1
6868	ADAM17	3
27255	CNTN6	2
1499	CTNNB1	8
27151	CPAMD8	2
3440	IFNA2	7
1436	CSF1R	6
167359	NIM1K	3
4486	MST1R	7
2904	GRIN2B	2
578	BAK1	3
1488	CTBP2	2

Gene in drug-gene network: Network Plot

Models in Piperlongumine

SITE

DATATYPES

CLASSFICATION

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