HDAC6
Summary: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplication of two catalytic domains which appear to function independently of each other. This protein possesses histone deacetylase activity and represses transcription. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| histone deacetylase 6 | MIM:300272 | Ensembl:ENSG00000094631 | HGNC:HGNC:14064 | PA29231 | Xp11.23 |
GO terms in HDAC6
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0000209 | protein polyubiquitination |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | IMP | GO:0006476 | protein deacetylation |
| BP | TAS | GO:0006476 | protein deacetylation |
| BP | IMP | GO:0006515 | protein quality control for misfolded or incompletely synthesized proteins |
| BP | IMP | GO:0006886 | intracellular protein transport |
| BP | IEA | GO:0006914 | autophagy |
| BP | IEA | GO:0007026 | negative regulation of microtubule depolymerization |
| BP | IMP | GO:0009636 | response to toxic substance |
| BP | IMP | GO:0009967 | positive regulation of signal transduction |
| BP | IMP | GO:0010033 | response to organic substance |
| BP | IMP | GO:0010469 | regulation of signaling receptor activity |
| BP | TAS | GO:0010506 | regulation of autophagy |
| BP | IMP | GO:0010634 | positive regulation of epithelial cell migration |
| BP | IC | GO:0010727 | negative regulation of hydrogen peroxide metabolic process |
| BP | IMP | GO:0010870 | positive regulation of receptor biosynthetic process |
| BP | IMP | GO:0016241 | regulation of macroautophagy |
| BP | IDA | GO:0016575 | histone deacetylation |
| BP | ISS | GO:0016575 | histone deacetylation |
| BP | IMP | GO:0031647 | regulation of protein stability |
| BP | IMP | GO:0032418 | lysosome localization |
| BP | IMP | GO:0032461 | positive regulation of protein oligomerization |
| BP | IEA | GO:0032984 | protein-containing complex disassembly |
| BP | IMP | GO:0033138 | positive regulation of peptidyl-serine phosphorylation |
| BP | IMP | GO:0034983 | peptidyl-lysine deacetylation |
| BP | IMP | GO:0035967 | cellular response to topologically incorrect protein |
| BP | IMP | GO:0040029 | regulation of gene expression, epigenetic |
| BP | IEA | GO:0043162 | ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway |
| BP | IMP | GO:0043242 | negative regulation of protein complex disassembly |
| BP | IEA | GO:0045598 | regulation of fat cell differentiation |
| BP | IMP | GO:0045861 | negative regulation of proteolysis |
| BP | ISS | GO:0045892 | negative regulation of transcription, DNA-templated |
| BP | IEA | GO:0048668 | collateral sprouting |
| BP | IC | GO:0051354 | negative regulation of oxidoreductase activity |
| BP | IEA | GO:0051646 | mitochondrion localization |
| BP | IMP | GO:0051788 | response to misfolded protein |
| BP | TAS | GO:0060271 | cilium assembly |
| BP | IC | GO:0060632 | regulation of microtubule-based movement |
| BP | TAS | GO:0060765 | regulation of androgen receptor signaling pathway |
| BP | IEA | GO:0060997 | dendritic spine morphogenesis |
| BP | IGI | GO:0061734 | parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization |
| BP | IEA | GO:0070201 | regulation of establishment of protein localization |
| BP | IMP | GO:0070301 | cellular response to hydrogen peroxide |
| BP | IMP | GO:0070842 | aggresome assembly |
| BP | IMP | GO:0070845 | polyubiquitinated misfolded protein transport |
| BP | IMP | GO:0070846 | Hsp90 deacetylation |
| BP | IMP | GO:0070848 | response to growth factor |
| BP | IEA | GO:0070932 | histone H3 deacetylation |
| BP | IEA | GO:0071218 | cellular response to misfolded protein |
| BP | IMP | GO:0090035 | positive regulation of chaperone-mediated protein complex assembly |
| BP | IDA | GO:0090042 | tubulin deacetylation |
| BP | ISS | GO:0090042 | tubulin deacetylation |
| BP | TAS | GO:0090042 | tubulin deacetylation |
| BP | IDA | GO:1901300 | positive regulation of hydrogen peroxide-mediated programmed cell death |
| BP | TAS | GO:1903146 | regulation of autophagy of mitochondrion |
| CC | IDA | GO:0000118 | histone deacetylase complex |
| CC | ISS | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | ISS | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005771 | multivesicular body |
| CC | ISS | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0005874 | microtubule |
| CC | IDA | GO:0005875 | microtubule associated complex |
| CC | IEA | GO:0005881 | cytoplasmic microtubule |
| CC | IDA | GO:0005901 | caveola |
| CC | IDA | GO:0016234 | inclusion body |
| CC | IDA | GO:0016235 | aggresome |
| CC | TAS | GO:0016235 | aggresome |
| CC | IDA | GO:0030286 | dynein complex |
| CC | ISS | GO:0030424 | axon |
| CC | ISS | GO:0030425 | dendrite |
| CC | IDA | GO:0031252 | cell leading edge |
| CC | ISS | GO:0043204 | perikaryon |
| CC | IDA | GO:0048471 | perinuclear region of cytoplasm |
| MF | IDA | GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | IEA | GO:0003779 | actin binding |
| MF | IDA | GO:0004407 | histone deacetylase activity |
| MF | IMP | GO:0004407 | histone deacetylase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0008013 | beta-catenin binding |
| MF | IDA | GO:0008017 | microtubule binding |
| MF | ISS | GO:0008017 | microtubule binding |
| MF | IEA | GO:0008270 | zinc ion binding |
| MF | ISS | GO:0019899 | enzyme binding |
| MF | IDA | GO:0031593 | polyubiquitin modification-dependent protein binding |
| MF | IPI | GO:0031625 | ubiquitin protein ligase binding |
| MF | IEA | GO:0032041 | NAD-dependent histone deacetylase activity (H3-K14 specific) |
| MF | IPI | GO:0042826 | histone deacetylase binding |
| MF | IDA | GO:0042903 | tubulin deacetylase activity |
| MF | IMP | GO:0042903 | tubulin deacetylase activity |
| MF | ISS | GO:0042903 | tubulin deacetylase activity |
| MF | TAS | GO:0042903 | tubulin deacetylase activity |
| MF | IDA | GO:0043014 | alpha-tubulin binding |
| MF | IEA | GO:0043130 | ubiquitin binding |
| MF | IDA | GO:0048156 | tau protein binding |
| MF | ISS | GO:0048156 | tau protein binding |
| MF | TAS | GO:0048156 | tau protein binding |
| MF | IEA | GO:0048487 | beta-tubulin binding |
| MF | EXP | GO:0051787 | misfolded protein binding |
| MF | IDA | GO:0051879 | Hsp90 protein binding |
| MF | IDA | GO:0070840 | dynein complex binding |
Gene expression in normal tissue: HDAC6
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in HDAC6
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-157118 | Signaling by NOTCH |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-1852241 | Organelle biogenesis and maintenance |
| reactome | R-HSA-1980143 | Signaling by NOTCH1 |
| reactome | R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-2262752 | Cellular responses to stress |
| reactome | R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer |
| reactome | R-HSA-2644603 | Signaling by NOTCH1 in Cancer |
| reactome | R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants |
| reactome | R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer |
| reactome | R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants |
| reactome | R-HSA-3371511 | HSF1 activation |
| reactome | R-HSA-3371556 | Cellular response to heat stress |
| reactome | R-HSA-5617833 | Cilium Assembly |
| reactome | R-HSA-5663202 | Diseases of signal transduction |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-8878166 | Transcriptional regulation by RUNX2 |
| reactome | R-HSA-8878166 | Transcriptional regulation by RUNX2 |
| reactome | R-HSA-8940973 | RUNX2 regulates osteoblast differentiation |
| reactome | R-HSA-8941326 | RUNX2 regulates bone development |
| reactome | R-HSA-8953897 | Cellular responses to external stimuli |
| biocarta | ranbp2pathway | sumoylation by ranbp2 regulates transcriptional repression |
| kegg | hsa05034 | Alcoholism - Homo sapiens (human) |
| kegg | hsa05165 | Human papillomavirus infection - Homo sapiens (human) |
| kegg | hsa05203 | Viral carcinogenesis - Homo sapiens (human) |
| pid | hdac_classii_pathway | Signaling events mediated by HDAC Class II |
| netpath | Pathway_TNFalpha | TNFalpha |
| wikipathways | WP179 | Cell Cycle |
| wikipathways | WP2064 | Neural Crest Differentiation |
| wikipathways | WP2858 | Ectoderm Differentiation |
| wikipathways | WP3996 | Ethanol effects on histone modifications |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD314 | Tanespimycin | 4 |
| iGMDRD341 | Triacsin c | 3 |
| iGMDRD154 | NSC23766 | 6 |
| iGMDRD901 | ELCPK | 2 |
| iGMDRD211 | (1S,3R)-RSL3 | 2 |
| iGMDRD123 | Isoevodiamine | 2 |
| iGMDRD177 | Teniposide | 1 |
| iGMDRD512 | nutlin 3 | 3 |
| iGMDRD532 | Olaparib | 2 |
| iGMDRD150 | RITA | 7 |
| iGMDRD424 | Tamatinib | 2 |
| iGMDRD329 | Merck60 | 3 |
| iGMDRD366 | PI-103 | 5 |
| iGMDRD286 | Nsc 632839 | 3 |
| iGMDRD414 | MST-312 | 3 |
| iGMDRD300 | Tozasertib | 4 |
| iGMDRD886 | Compound 1541A | 3 |
| iGMDRD158 | NSC141540 | 6 |
| iGMDRD137 | Indisulam | 1 |
| iGMDRD289 | Parthenolide | 2 |
| iGMDRD434 | BMS-536924 | 1 |
| iGMDRD639 | YK 4-279 | 3 |
| iGMDRD375 | GW-405833 | 3 |
| iGMDRD280 | CYTOCHALASIN B | 1 |
| iGMDRD144 | NSC95397 | 3 |
| iGMDRD427 | ABT737 | 5 |
| iGMDRD506 | Fedratinib | 1 |
| iGMDRD188 | Piperlongumine | 5 |
| iGMDRD74 | Idarubicin | 6 |
| iGMDRD730 | Kahalalide F | 2 |
| iGMDRD23 | Gossypol | 1 |
| iGMDRD444 | Tivantinib | 2 |
| iGMDRD451 | Serdemetan | 2 |
| iGMDRD64 | Parbendazole | 1 |
| iGMDRD802 | 4-methylfasudil | 3 |
| iGMDRD138 | PX 12 | 3 |
| iGMDRD801 | 2,4-dideoxy-DC-45-A2 | 3 |
| iGMDRD309 | 17AAG | 1 |
| iGMDRD187 | BRD9876 | 1 |
| iGMDRD171 | Pemetrexed | 1 |
| iGMDRD782 | DC-45-A2 | 5 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in HDAC6
CLASSFICATION
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