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iGMDRD286

Canonical SMILES: CC1=CC=C(C=C1)C=C2CNCC(=CC3=CC=C(C=C3)C)C2=O.Cl

InChI: InChI=1S/C21H21NO.ClH/c1-15-3-7-17(8-4-15)11-19-13-22-14-20(21(19)23)12-18-9-5-16(2)6-10-18;/h3-12,22H,13-14H2,1-2H3;1H/b19-11+,20-12+;

InChI Key: ZOKZLTXPTLIWOJ-BYCVLTJGSA-N

Standard Name	Pubchem CID	Drug Status	Drug Type
Nsc 632839	5351360	Alone	Small Molecule

Drug-model tissue-cancer distribution: Bubble Plot

Drug-gene pathway enrichments

Drug-gene GO enrichments

Drug-Gene: Aster Plot

Gene ID	Gene Name	Model Num.
3696	ITGB8	3
1105	CHD1	2
27125	AFF4	2
4854	NOTCH3	3
7514	XPO1	1
8999	CDKL2	2
5296	PIK3R2	3
5027	P2RX7	3
10903	MTMR11	2
79848	CSPP1	1
6491	STIL	1
5261	PHKG2	3
10987	COPS5	6
21	ABCA3	3
132	ADK	3
3383	ICAM1	3
6774	STAT3	3
8915	BCL10	3
7161	TP73	1
7750	ZMYM2	5
4926	NUMA1	2
2048	EPHB2	3
4627	MYH9	2
4168	MCF2	3
2956	MSH6	4
2200	FBN1	2
4303	FOXO4	3
57679	ALS2	6
1520	CTSS	8
57554	LRRC7	7
9706	ULK2	2
93	ACVR2B	2
3845	KRAS	4
51347	TAOK3	2
55215	FANCI	1
8289	ARID1A	8
701	BUB1B	3
3939	LDHA	2
5934	RBL2	2
25778	DSTYK	3
53616	ADAM22	7
6938	TCF12	4
6597	SMARCA4	3
3551	IKBKB	3
81035	COLEC12	3
9869	SETDB1	8
4036	LRP2	4
11160	ERLIN2	1
11116	FGFR1OP	5
10320	IKZF1	1
3209	HOXA13	2
390502	SERPINA2	3
5754	PTK7	4
64783	RBM15	4
51684	SUFU	4
10892	MALT1	6
4771	NF2	4
23235	SIK2	7
10863	ADAM28	2
6598	SMARCB1	6
9891	NUAK1	3
4170	MCL1	2
23213	SULF1	6
5218	CDK14	3
3066	HDAC2	3
55781	RIOK2	3
23310	NCAPD3	3
6732	SRPK1	2
5298	PI4KB	3
27	ABL2	2
8749	ADAM18	3
3841	KPNA5	4
2241	FER	3
22821	RASA3	9
9816	URB2	3
84299	MIEN1	8
79934	COQ8B	5
577	ADGRB3	2
28231	SLCO4A1	2
1387	CREBBP	4
1893	ECM1	4
10454	TAB1	3
3727	JUND	6
8844	KSR1	6
2885	GRB2	3
5788	PTPRC	2
23225	NUP210	1
2313	FLI1	3
4283	CXCL9	2
10013	HDAC6	3
5579	PRKCB	4
11200	CHEK2	3
10178	TENM1	1
9699	RIMS2	2
79858	NEK11	4
5596	MAPK4	2
5966	REL	3
9411	ARHGAP29	6
85021	REPS1	2
3604	TNFRSF9	5
8295	TRRAP	4
26576	SRPK3	5
2977	GUCY1A2	2
10438	C1D	3
11122	PTPRT	2
9024	BRSK2	3
5396	PRRX1	5
10215	OLIG2	3
5314	PKHD1	6
5605	MAP2K2	3
139378	ADGRG4	3
7158	TP53BP1	5
55294	FBXW7	2
10295	BCKDK	2
2033	EP300	5
6927	HNF1A	3
54567	DLL4	1
8784	TNFRSF18	4
5664	PSEN2	3
641	BLM	5
5914	RARA	10
64324	NSD1	3
83439	TCF7L1	5
23522	KAT6B	2
55728	N4BP2	2
1453	CSNK1D	3
25925	ZNF521	4
102	ADAM10	2
54477	PLEKHA5	7
57670	KIAA1549	2
4610	MYCL	1
2115	ETV1	1
4301	AFDN	3
816	CAMK2B	5
84033	OBSCN	6
5607	MAP2K5	2
51776	MAP3K20	3
342977	NANOS3	1
256646	NUTM1	2
2268	FGR	3
388228	SBK1	3
7025	NR2F1	5
1880	GPR183	4
9693	RAPGEF2	3
57787	MARK4	4
4478	MSN	3
222484	LNX2	5
1586	CYP17A1	6
8549	LGR5	3
8852	AKAP4	7
22806	IKZF3	3
166614	DCLK2	2
4005	LMO2	2
3645	INSRR	3
5468	PPARG	2
80351	TNKS2	2
8313	AXIN2	3
6733	SRPK2	6
6091	ROBO1	6
1050	CEBPA	1
2260	FGFR1	9
5330	PLCB2	3
10217	CTDSPL	1
4216	MAP3K4	1
2736	GLI2	1
83990	BRIP1	5
51804	SIX4	2
4194	MDM4	1
7088	TLE1	5
5898	RALA	3
4982	TNFRSF11B	3
23405	DICER1	4
1277	COL1A1	2
171019	ADAMTS19	8
375449	MAST4	5
2064	ERBB2	6
94103	ORMDL3	8
287015	TRIM42	3
83983	TSSK6	2
65217	PCDH15	10
8395	PIP5K1B	4
54899	PXK	3
286826	LIN9	3
7486	WRN	3
440730	TRIM67	3
23387	SIK3	2
1456	CSNK1G3	2
783	CACNB2	2
5580	PRKCD	3
9759	HDAC4	3
1452	CSNK1A1	2
8714	ABCC3	3
10400	PEMT	2
5286	PIK3C2A	3
64170	CARD9	3
6709	SPTAN1	6
219970	GLYATL2	1
158056	MAMDC4	2
2068	ERCC2	2
5591	PRKDC	5
5568	PRKACG	3
6464	SHC1	2
6098	ROS1	5
9472	AKAP6	2
157285	PRAG1	3
54437	SEMA5B	5
8515	ITGA10	1
2778	GNAS	4
6917	TCEA1	2
3667	IRS1	4
80243	PREX2	6
472	ATM	2
8945	BTRC	2
5165	PDK3	6
1009	CDH11	5
8148	TAF15	3
28996	HIPK2	5
575	ADGRB1	3
53942	CNTN5	6
9564	BCAR1	5
4804	NGFR	3
4058	LTK	3
1123	CHN1	2
1496	CTNNA2	5
7010	TEK	2
7533	YWHAH	3
5289	PIK3C3	5
5450	POU2AF1	6
23152	CIC	1
2272	FHIT	2
2066	ERBB4	2
904	CCNT1	2
1647	GADD45A	6
5327	PLAT	6
9319	TRIP13	1
10413	YAP1	6
2201	FBN2	2
1029	CDKN2A	6
7184	HSP90B1	1
9794	MAML1	3
27436	EML4	4
284656	EPHA10	3
57523	NYNRIN	2
2868	GRK4	4
657	BMPR1A	4
861	RUNX1	2
149420	PDIK1L	3
5834	PYGB	1
3932	LCK	6
7157	TP53	1
2099	ESR1	2
4173	MCM4	2
4602	MYB	1
79058	ASPSCR1	5
6714	SRC	1
57194	ATP10A	4
25836	NIPBL	2
7869	SEMA3B	1
8218	CLTCL1	5
57410	SCYL1	4
836	CASP3	4
8061	FOSL1	1
4292	MLH1	10
93210	PGAP3	7
114788	CSMD3	5
2263	FGFR2	4
4086	SMAD1	1
6199	RPS6KB2	6
106480993	RN7SL263P	6
8408	ULK1	3
7249	TSC2	3
65243	ZFP69B	5
9967	THRAP3	3
1045	CDX2	3
4869	NPM1	1
64386	MMP25	3
344387	CDKL4	3
863	CBFA2T3	5
1555	CYP2B6	1
51086	TNNI3K	2
5597	MAPK6	2
55437	STRADB	3
2309	FOXO3	1
369	ARAF	3
4921	DDR2	1
6197	RPS6KA3	9
57188	ADAMTSL3	2
65125	WNK1	2
57591	MRTFA	3
652	BMP4	5
6035	RNASE1	6
676	BRDT	6
984	CDK11B	2
5650	KLK7	2
7175	TPR	3
5871	MAP4K2	6
5608	MAP2K6	2
54106	TLR9	3
23365	ARHGEF12	1
84181	CHD6	5
4026	LPP	6
8997	KALRN	6
6795	AURKC	6
23269	MGA	2
3643	INSR	3
6280	S100A9	2
5371	PML	1
23469	PHF3	2
170692	ADAMTS18	2
7471	WNT1	6
6654	SOS1	6
672	BRCA1	8
1616	DAXX	2
10948	STARD3	5
2737	GLI3	2
4139	MARK1	2
7204	TRIO	4
9252	RPS6KA5	3
78989	COLEC11	2
23373	CRTC1	1
9448	MAP4K4	2
3426	CFI	5
2047	EPHB1	3
5069	PAPPA	2
7786	MAP3K12	3
10769	PLK2	3
64840	PORCN	4
30827	CXXC1	4
56997	COQ8A	3
8216	LZTR1	1
4214	MAP3K1	1
3702	ITK	4
9972	NUP153	2
3239	HOXD13	6
5290	PIK3CA	2
92335	STRADA	3
3720	JARID2	5
5034	P4HB	10
1687	GSDME	5
7043	TGFB3	3
85366	MYLK2	1
2318	FLNC	3
57154	SMURF1	6
5530	PPP3CA	4
675	BRCA2	6
607	BCL9	5
4803	NGF	4
10155	TRIM28	6
7075	TIE1	2
1956	EGFR	1
8445	DYRK2	2
640	BLK	4
841	CASP8	3
2735	GLI1	1
4609	MYC	3
11064	CNTRL	3
5789	PTPRD	5
5599	MAPK8	3
8013	NR4A3	3
10461	MERTK	2
51321	AMZ2	5
100130933	SMIM6	6
4684	NCAM1	2
26278	SACS	5
1031	CDKN2C	3
894	CCND2	3
283629	TSSK4	3
896	CCND3	2
1440	CSF3	8
79759	ZNF668	2
5592	PRKG1	3
3635	INPP5D	7
1653	DDX1	5
5187	PER1	2
7917	BAG6	3
375056	MIA3	2
10971	YWHAQ	9
93627	TBCK	4
137872	ADHFE1	10
56924	PAK6	2
23005	MAPKBP1	6
10186	LHFPL6	7
203102	ADAM32	3
673	BRAF	1
7153	TOP2A	13
84630	TTBK1	4
1981	EIF4G1	2
4790	NFKB1	3
84879	MFSD2A	3
22976	PAXIP1	4
23532	PRAME	5
780	DDR1	2
83452	RAB33B	3
8924	HERC2	5
2078	ERG	3
339345	NANOS2	3
120892	LRRK2	5
89795	NAV3	4
65268	WNK2	5
6095	RORA	7
146057	TTBK2	6
1677	DFFB	3
7301	TYRO3	1
93273	LEMD1	6
7468	NSD2	3
11184	MAP4K1	3
5128	CDK17	7
9113	LATS1	4
460	ASTN1	3
9064	MAP3K6	2
5294	PIK3CG	2
5979	RET	3
9451	EIF2AK3	4
1977	EIF4E	6
8491	MAP4K3	1
4853	NOTCH2	3
1230	CCR1	3
9509	ADAMTS2	3
266747	RGL4	1
5563	PRKAA2	2
23396	PIP5K1C	2
23742	NPAP1	2
5728	PTEN	3
57521	RPTOR	2
208	AKT2	1
51330	TNFRSF12A	3
51592	TRIM33	2
7030	TFE3	2
2316	FLNA	3
8888	MCM3AP	4
7155	TOP2B	4
80124	VCPIP1	3
22883	CLSTN1	2
667	DST	4
23281	MTUS2	1
4004	LMO1	3
3554	IL1R1	3
140803	TRPM6	6
4317	MMP8	3
2324	FLT4	3
10962	MLLT11	5
177	AGER	3
5896	RAG1	3
8301	PICALM	3
4055	LTBR	6
28954	REM1	3
7273	TTN	4
1445	CSK	3
79834	PEAK1	5
2119	ETV5	3
85415	RHPN2	2
23389	MED13L	6
6787	NEK4	4
2277	VEGFD	1
8667	EIF3H	6
23411	SIRT1	1
8648	NCOA1	3
29941	PKN3	3
79012	CAMKV	2
9372	ZFYVE9	7
55561	CDC42BPG	3
2046	EPHA8	3
128869	PIGU	2
10243	GPHN	6
5532	PPP3CB	2
9943	OXSR1	5
22843	PPM1E	1
2353	FOS	2
286151	FBXO43	2
5588	PRKCQ	6
4297	KMT2A	4
558	AXL	2
7248	TSC1	4
126792	B3GALT6	1
83417	FCRL4	4
5581	PRKCE	3
5923	RASGRF1	3
2317	FLNB	7
100124696	TEC	3
9223	MAGI1	1
5395	PMS2	2
778	CACNA1F	6
171389	NLRP6	2
140913	PPIAP10	3
53353	LRP1B	1
9659	PDE4DIP	8
63976	PRDM16	8
2049	EPHB3	3
283455	KSR2	2
6093	ROCK1	2
131890	GRK7	3
2194	FASN	6
5927	KDM5A	6
598	BCL2L1	2
3579	CXCR2	3
55007	FAM118A	2
5589	PRKCSH	3
2321	FLT1	3
6196	RPS6KA2	2
57448	BIRC6	4
57007	ACKR3	3
2304	FOXE1	3
8317	CDC7	2
3717	JAK2	5
23139	MAST2	4
2157	F8	2
7227	TRPS1	3
53335	BCL11A	4
1627	DBN1	2
79837	PIP4K2C	6
3709	ITPR2	2
6778	STAT6	4
4221	MEN1	1
4067	LYN	1
65267	WNK3	1
84254	CAMKK1	3
3984	LIMK1	2
8428	STK24	5
6777	STAT5B	2
8569	MKNK1	3
7112	TMPO	3
84072	HORMAD1	7
11076	TPPP	8
2122	MECOM	4
2903	GRIN2A	3
4974	OMG	5
5925	RB1	8
4893	NRAS	2
5584	PRKCI	3
1026	CDKN1A	7
2065	ERBB3	5
2074	ERCC6	2
8661	EIF3A	5
7403	KDM6A	5
2308	FOXO1	7
81629	TSSK3	3
7508	XPC	3
4615	MYD88	3
112268437	LOC112268437	3
8841	HDAC3	2
4638	MYLK	3
51364	ZMYND10	6
255239	ANKK1	3
5586	PKN2	1
7040	TGFB1	6
3488	IGFBP5	2
3480	IGF1R	3
2011	MARK2	4
79728	PALB2	2
10494	STK25	4
4299	AFF1	3
2261	FGFR3	3
139604	MAGEB16	2
5567	PRKACB	2
84446	BRSK1	1
55422	ZNF331	4
1013	CDH15	7
581	BAX	3
156	GRK2	3
5260	PHKG1	6
4613	MYCN	2
63893	UBE2O	4
1840	DTX1	3
57096	RPGRIP1	3
2044	EPHA5	2
5287	PIK3C2B	2
4629	MYH11	1
6868	ADAM17	7
23112	TNRC6B	3
2178	FANCE	1
27255	CNTN6	2
3895	KTN1	3
1499	CTNNB1	5
2444	FRK	7
3440	IFNA2	4
56155	TEX14	3
2892	GRIA3	8
4916	NTRK3	4
2886	GRB7	6
167359	NIM1K	1
4486	MST1R	3
5624	PROC	3
5970	RELA	2
1488	CTBP2	2

Gene in drug-gene network: Network Plot

Models in Nsc 632839

SITE

DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.