ZFYVE9


Summary: This gene encodes a double zinc finger motif-containing protein that participates in the transforming growth factor-beta (TGFB) signalling pathway. The encoded protein interacts directly with SMAD2 and SMAD3, and recruits SMAD2 to the TGFB receptor. There are multiple pseudogenes for this gene on chromosomes 2, 15, and X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
zinc finger FYVE-type containing 9MIM:603755Ensembl:ENSG00000157077HGNC:HGNC:6775PA305321p32.3

Gene Categories:

PROTEASE

GO terms in ZFYVE9


Term TypeEvidence TypeGO Term IDGO Des.
MFIPIGO:0005515protein binding
MFIDAGO:00055451-phosphatidylinositol binding
MFNASGO:0008236serine-type peptidase activity
MFIPIGO:0019904protein domain specific binding
MFIEAGO:0046872metal ion binding
CCIBAGO:0005769early endosome
CCNASGO:0005769early endosome
CCIDAGO:0005829cytosol
CCIDAGO:0031901early endosome membrane
CCTASGO:0031901early endosome membrane
CCIMPGO:0032991protein-containing complex
CCIDAGO:0043231intracellular membrane-bounded organelle
BPIEAGO:0006508proteolysis
BPIBAGO:0006886intracellular protein transport
BPNASGO:0006897endocytosis
BPIMPGO:0007179transforming growth factor beta receptor signaling pathway
BPNASGO:0007179transforming growth factor beta receptor signaling pathway
BPTASGO:0007179transforming growth factor beta receptor signaling pathway
BPIBAGO:0015031protein transport
BPIBAGO:0016197endosomal transport

Gene expression in normal tissue: ZFYVE9

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ZFYVE9


DatabasePathway IDPathway Des.
pidtgfbrpathwayTGF-beta receptor signaling
netpathPathway_TGF_beta_ReceptorTGF_beta_Receptor
kegghsa04144Endocytosis - Homo sapiens (human)
kegghsa04350TGF-beta signaling pathway - Homo sapiens (human)
wikipathwaysWP366TGF-beta Signaling Pathway
wikipathwaysWP560TGF-beta Receptor Signaling
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-1643685Disease
reactomeR-HSA-170834Signaling by TGF-beta Receptor Complex
reactomeR-HSA-170834Signaling by TGF-beta Receptor Complex
reactomeR-HSA-2173788Downregulation of TGF-beta receptor signaling
reactomeR-HSA-2173789TGF-beta receptor signaling activates SMADs
reactomeR-HSA-2173789TGF-beta receptor signaling activates SMADs
reactomeR-HSA-3304349Loss of Function of SMAD2/3 in Cancer
reactomeR-HSA-3304351Signaling by TGF-beta Receptor Complex in Cancer
reactomeR-HSA-3304356SMAD2/3 Phosphorylation Motif Mutants in Cancer
reactomeR-HSA-3315487SMAD2/3 MH2 Domain Mutants in Cancer
reactomeR-HSA-3656532TGFBR1 KD Mutants in Cancer
reactomeR-HSA-3656534Loss of Function of TGFBR1 in Cancer
reactomeR-HSA-5663202Diseases of signal transduction
reactomeR-HSA-9006936Signaling by TGF-beta family members
reactomeR-HSA-9006936Signaling by TGF-beta family members

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD213SMR0000686504
iGMDRD105Triptolide3
iGMDRD289Parthenolide3
iGMDRD434BMS-5369241
iGMDRD5Tyrphostin AG 14781
iGMDRD121GMX17783
iGMDRD82Quiflapon3
iGMDRD322FK 8664
iGMDRD505Pevonedistat4
iGMDRD147Prima-14
iGMDRD286Nsc 6328397
iGMDRD872BRD71371
iGMDRD150RITA7
iGMDRD522ML-0301
iGMDRD148Pifithrin-mu3
iGMDRD248BRD43541
iGMDRD84Lovastatin acid3
iGMDRD307Manumycin A3
iGMDRD945ML2143
iGMDRD211(1S,3R)-RSL33
iGMDRD177Teniposide3
iGMDRD314Tanespimycin2
iGMDRD57Chloropentafluorobenzene3
iGMDRD341Triacsin c2
iGMDRD85Ursolic acid4
iGMDRD441TW 373
iGMDRD885Compound 1103
iGMDRD318PAC-13
iGMDRD8012,4-dideoxy-DC-45-A25
iGMDRD294Batimastat3
iGMDRD782DC-45-A23
iGMDRD171Pemetrexed3
iGMDRD268Cerulenin6
iGMDRD524ISX-91
iGMDRD690PRIMA-1MET3
iGMDRD60Quinoclamine1
iGMDRD640CAY106183
iGMDRD224Necrostatin-14
iGMDRD888Compound 443
iGMDRD562Navitoclax3
iGMDRD100Zebularine3
iGMDRD188Piperlongumine5
iGMDRD779PRL-3 Inhibitor I1
iGMDRD427ABT7373
iGMDRD144NSC953973
iGMDRD670ML 2105
iGMDRD772BRD47706
iGMDRD634SCHEMBL26080418
iGMDRD61Kinetin riboside1
iGMDRD797ISOX DUAL3
iGMDRD201SKI II3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ZFYVE9

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