ZFYVE9
Summary: This gene encodes a double zinc finger motif-containing protein that participates in the transforming growth factor-beta (TGFB) signalling pathway. The encoded protein interacts directly with SMAD2 and SMAD3, and recruits SMAD2 to the TGFB receptor. There are multiple pseudogenes for this gene on chromosomes 2, 15, and X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:603755 Ensembl IDEnsembl:ENSG00000157077 HGNC IDHGNC:HGNC:6775 PHARMGKB IDPA30532 Map Location1p32.3 | |||||
Gene Categories:
PROTEASEGO terms in ZFYVE9
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0005545 | 1-phosphatidylinositol binding |
| MF | NAS | GO:0008236 | serine-type peptidase activity |
| MF | IPI | GO:0019904 | protein domain specific binding |
| MF | IEA | GO:0046872 | metal ion binding |
| CC | IBA | GO:0005769 | early endosome |
Gene expression in normal tissue: ZFYVE9
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ZFYVE9
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | tgfbrpathway | TGF-beta receptor signaling |
| netpath | Pathway_TGF_beta_Receptor | TGF_beta_Receptor |
| kegg | hsa04144 | Endocytosis - Homo sapiens (human) |
| kegg | hsa04350 | TGF-beta signaling pathway - Homo sapiens (human) |
| wikipathways | WP366 | TGF-beta Signaling Pathway |
| wikipathways | WP560 | TGF-beta Receptor Signaling |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ZFYVE9
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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