iGMDRD690
Standard Name | CHEMBL | Pubchem CID | DRUGBANK ID | Drug Status | Drug Type |
---|---|---|---|---|---|
PRIMA-1MET | CHEMBL3186011 | 52918400 | DB11684 | Alone | Small Molecule |
Drug Targets:
TP53Drug-model tissue-cancer distribution: Bubble Plot
Drug-gene pathway enrichments
Drug-gene GO enrichments
Drug-Gene: Aster Plot
Gene ID | Gene Name | Model Num. |
---|---|---|
6664 | SOX11 | 6 |
10221 | TRIB1 | 3 |
132 | ADK | 9 |
7750 | ZMYM2 | 1 |
5546 | PRCC | 2 |
51765 | STK26 | 6 |
57679 | ALS2 | 3 |
7272 | TTK | 2 |
3757 | KCNH2 | 1 |
4750 | NEK1 | 3 |
23552 | CDK20 | 2 |
80070 | ADAMTS20 | 3 |
3939 | LDHA | 2 |
2335 | FN1 | 3 |
6938 | TCF12 | 2 |
10395 | DLC1 | 3 |
6657 | SOX2 | 6 |
5079 | PAX5 | 3 |
23235 | SIK2 | 7 |
4170 | MCL1 | 1 |
55534 | MAML3 | 1 |
340371 | NRBP2 | 1 |
1387 | CREBBP | 9 |
2043 | EPHA4 | 3 |
5579 | PRKCB | 8 |
11200 | CHEK2 | 3 |
8295 | TRRAP | 2 |
54567 | DLL4 | 6 |
23522 | KAT6B | 7 |
440279 | UNC13C | 2 |
4610 | MYCL | 3 |
169436 | STKLD1 | 3 |
22806 | IKZF3 | 3 |
11169 | WDHD1 | 1 |
4739 | NEDD9 | 6 |
83931 | STK40 | 2 |
22858 | ICK | 2 |
287015 | TRIM42 | 2 |
23191 | CYFIP1 | 2 |
783 | CACNB2 | 2 |
57510 | XPO5 | 2 |
1973 | EIF4A1 | 3 |
6917 | TCEA1 | 6 |
5924 | RASGRF2 | 1 |
4087 | SMAD2 | 2 |
5450 | POU2AF1 | 7 |
2272 | FHIT | 4 |
2201 | FBN2 | 2 |
9794 | MAML1 | 2 |
157753 | TMEM74 | 8 |
8576 | STK16 | 3 |
7157 | TP53 | 1 |
6794 | STK11 | 1 |
8218 | CLTCL1 | 3 |
7249 | TSC2 | 2 |
65243 | ZFP69B | 5 |
344387 | CDKL4 | 3 |
3572 | IL6ST | 3 |
80205 | CHD9 | 2 |
2081 | ERN1 | 3 |
84181 | CHD6 | 2 |
8997 | KALRN | 8 |
4437 | MSH3 | 4 |
285220 | EPHA6 | 4 |
3426 | CFI | 2 |
10926 | DBF4 | 2 |
10769 | PLK2 | 3 |
5578 | PRKCA | 6 |
9972 | NUP153 | 3 |
3720 | JARID2 | 2 |
1687 | GSDME | 5 |
4293 | MAP3K9 | 2 |
5366 | PMAIP1 | 3 |
57154 | SMURF1 | 2 |
4609 | MYC | 3 |
90956 | ADCK2 | 3 |
7917 | BAG6 | 2 |
1544 | CYP1A2 | 6 |
93627 | TBCK | 2 |
4790 | NFKB1 | 3 |
23532 | PRAME | 5 |
780 | DDR1 | 2 |
2078 | ERG | 3 |
867 | CBL | 4 |
6095 | RORA | 2 |
93273 | LEMD1 | 3 |
11184 | MAP4K1 | 1 |
5294 | PIK3CG | 3 |
5979 | RET | 3 |
11262 | SP140 | 2 |
55290 | BRF2 | 3 |
9509 | ADAMTS2 | 3 |
8621 | CDK13 | 2 |
5563 | PRKAA2 | 6 |
10010 | TANK | 4 |
7030 | TFE3 | 3 |
667 | DST | 2 |
5305 | PIP4K2A | 3 |
7036 | TFR2 | 6 |
596 | BCL2 | 1 |
55359 | STYK1 | 3 |
53904 | MYO3A | 4 |
9372 | ZFYVE9 | 3 |
4297 | KMT2A | 2 |
51151 | SLC45A2 | 3 |
558 | AXL | 3 |
2690 | GHR | 2 |
9021 | SOCS3 | 3 |
55289 | ACOXL | 6 |
2049 | EPHB3 | 3 |
6093 | ROCK1 | 3 |
1719 | DHFR | 4 |
3717 | JAK2 | 2 |
80216 | ALPK1 | 5 |
4261 | CIITA | 3 |
3656 | IRAK2 | 5 |
444 | ASPH | 6 |
7403 | KDM6A | 2 |
2308 | FOXO1 | 3 |
9878 | TOX4 | 3 |
581 | BAX | 3 |
10891 | PPARGC1A | 6 |
23683 | PRKD3 | 3 |
7294 | TXK | 3 |
2178 | FANCE | 2 |
1436 | CSF1R | 3 |
5685 | PSMA4 | 3 |
Gene in drug-gene network: Network Plot
![](image/drug_network_legends.png)
Models in PRIMA-1MET