IL6ST
Summary: The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants have been described. A related pseudogene has been identified on chromosome 17. [provided by RefSeq, May 2014].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:600694 Ensembl IDEnsembl:ENSG00000134352 HGNC IDHGNC:HGNC:6021 PHARMGKB IDPA29837 Map Location5q11.2 | |||||
GO terms in IL6ST
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0004896 | cytokine receptor activity |
| MF | IDA | GO:0004897 | ciliary neurotrophic factor receptor activity |
| MF | IBA | GO:0004915 | interleukin-6 receptor activity |
| MF | IDA | GO:0004915 | interleukin-6 receptor activity |
| MF | IEA | GO:0004921 | interleukin-11 receptor activity |
| MF | IBA | GO:0004923 | leukemia inhibitory factor receptor activity |
Gene expression in normal tissue: IL6ST
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in IL6ST
Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1059683 | Interleukin-6 signaling |
| reactome | R-HSA-1059683 | Interleukin-6 signaling |
| reactome | R-HSA-110056 | MAPK3 (ERK1) activation |
| reactome | R-HSA-112409 | RAF-independent MAPK1/3 activation |
| reactome | R-HSA-112411 | MAPK1 (ERK2) activation |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in IL6ST
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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