IL6ST
Summary: The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants have been described. A related pseudogene has been identified on chromosome 17. [provided by RefSeq, May 2014].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| interleukin 6 signal transducer | MIM:600694 | Ensembl:ENSG00000134352 | HGNC:HGNC:6021 | PA29837 | 5q11.2 |
GO terms in IL6ST
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0004896 | cytokine receptor activity |
| MF | IDA | GO:0004897 | ciliary neurotrophic factor receptor activity |
| MF | IBA | GO:0004915 | interleukin-6 receptor activity |
| MF | IDA | GO:0004915 | interleukin-6 receptor activity |
| MF | IEA | GO:0004921 | interleukin-11 receptor activity |
| MF | IBA | GO:0004923 | leukemia inhibitory factor receptor activity |
| MF | IDA | GO:0004923 | leukemia inhibitory factor receptor activity |
| MF | IBA | GO:0004924 | oncostatin-M receptor activity |
| MF | IDA | GO:0004924 | oncostatin-M receptor activity |
| MF | IBA | GO:0005127 | ciliary neurotrophic factor receptor binding |
| MF | IPI | GO:0005127 | ciliary neurotrophic factor receptor binding |
| MF | IBA | GO:0005138 | interleukin-6 receptor binding |
| MF | IPI | GO:0005138 | interleukin-6 receptor binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0019838 | growth factor binding |
| MF | IPI | GO:0019838 | growth factor binding |
| MF | IBA | GO:0019955 | cytokine binding |
| MF | IEA | GO:0019970 | interleukin-11 binding |
| MF | IBA | GO:0019981 | interleukin-6 binding |
| MF | IPI | GO:0019981 | interleukin-6 binding |
| MF | TAS | GO:0042803 | protein homodimerization activity |
| MF | IC | GO:0045509 | interleukin-27 receptor activity |
| BP | IC | GO:0002675 | positive regulation of acute inflammatory response |
| BP | IC | GO:0002821 | positive regulation of adaptive immune response |
| BP | IEA | GO:0005977 | glycogen metabolic process |
| BP | IBA | GO:0008284 | positive regulation of cell proliferation |
| BP | IDA | GO:0008284 | positive regulation of cell proliferation |
| BP | IGI | GO:0008284 | positive regulation of cell proliferation |
| BP | IEA | GO:0008593 | regulation of Notch signaling pathway |
| BP | IBA | GO:0009966 | regulation of signal transduction |
| BP | TAS | GO:0010575 | positive regulation of vascular endothelial growth factor production |
| BP | TAS | GO:0010613 | positive regulation of cardiac muscle hypertrophy |
| BP | IEA | GO:0016032 | viral process |
| BP | IDA | GO:0019221 | cytokine-mediated signaling pathway |
| BP | TAS | GO:0019221 | cytokine-mediated signaling pathway |
| BP | IDA | GO:0034097 | response to cytokine |
| BP | IEA | GO:0038154 | interleukin-11-mediated signaling pathway |
| BP | IMP | GO:0038165 | oncostatin-M-mediated signaling pathway |
| BP | IBA | GO:0042102 | positive regulation of T cell proliferation |
| BP | IMP | GO:0042102 | positive regulation of T cell proliferation |
| BP | IBA | GO:0042531 | positive regulation of tyrosine phosphorylation of STAT protein |
| BP | IMP | GO:0042531 | positive regulation of tyrosine phosphorylation of STAT protein |
| BP | TAS | GO:0043066 | negative regulation of apoptotic process |
| BP | IMP | GO:0045669 | positive regulation of osteoblast differentiation |
| BP | IEA | GO:0048711 | positive regulation of astrocyte differentiation |
| BP | IDA | GO:0048861 | leukemia inhibitory factor signaling pathway |
| BP | IBA | GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation |
| BP | IMP | GO:0070102 | interleukin-6-mediated signaling pathway |
| BP | TAS | GO:0070102 | interleukin-6-mediated signaling pathway |
| BP | IMP | GO:0070106 | interleukin-27-mediated signaling pathway |
| BP | TAS | GO:0070106 | interleukin-27-mediated signaling pathway |
| BP | IDA | GO:0070120 | ciliary neurotrophic factor-mediated signaling pathway |
| BP | TAS | GO:0070757 | interleukin-35-mediated signaling pathway |
| CC | TAS | GO:0005576 | extracellular region |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IBA | GO:0005896 | interleukin-6 receptor complex |
| CC | IDA | GO:0005896 | interleukin-6 receptor complex |
| CC | IBA | GO:0005900 | oncostatin-M receptor complex |
| CC | IDA | GO:0005900 | oncostatin-M receptor complex |
| CC | IBA | GO:0009897 | external side of plasma membrane |
| CC | IEA | GO:0009897 | external side of plasma membrane |
| CC | HDA | GO:0016020 | membrane |
| CC | IEA | GO:0030425 | dendrite |
| CC | IEA | GO:0043025 | neuronal cell body |
| CC | IBA | GO:0043235 | receptor complex |
| CC | HDA | GO:0070062 | extracellular exosome |
| CC | IBA | GO:0070110 | ciliary neurotrophic factor receptor complex |
| CC | IDA | GO:0070110 | ciliary neurotrophic factor receptor complex |
Gene expression in normal tissue: IL6ST
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in IL6ST
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1059683 | Interleukin-6 signaling |
| reactome | R-HSA-1059683 | Interleukin-6 signaling |
| reactome | R-HSA-110056 | MAPK3 (ERK1) activation |
| reactome | R-HSA-112409 | RAF-independent MAPK1/3 activation |
| reactome | R-HSA-112411 | MAPK1 (ERK2) activation |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-447115 | Interleukin-12 family signaling |
| reactome | R-HSA-447115 | Interleukin-12 family signaling |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-5683057 | MAPK family signaling cascades |
| reactome | R-HSA-5684996 | MAPK1/MAPK3 signaling |
| reactome | R-HSA-6783589 | Interleukin-6 family signaling |
| reactome | R-HSA-6783589 | Interleukin-6 family signaling |
| reactome | R-HSA-6788467 | IL-6-type cytokine receptor ligand interactions |
| reactome | R-HSA-8984722 | Interleukin-35 Signalling |
| reactome | R-HSA-9020956 | Interleukin-27 signaling |
| reactome | R-HSA-9020956 | Interleukin-27 signaling |
| pid | il27pathway | IL27-mediated signaling events |
| pid | il6_7pathway | IL6-mediated signaling events |
| pid | shp2_pathway | SHP2 signaling |
| netpath | Pathway_AndrogenReceptor | AndrogenReceptor |
| netpath | Pathway_IL11 | IL11 |
| netpath | Pathway_IL6 | IL6 |
| netpath | Pathway_Oncostatin_M | Oncostatin_M |
| kegg | hsa04060 | Cytokine-cytokine receptor interaction - Homo sapiens (human) |
| kegg | hsa04550 | Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human) |
| kegg | hsa04630 | Jak-STAT signaling pathway - Homo sapiens (human) |
| kegg | hsa04659 | Th17 cell differentiation - Homo sapiens (human) |
| kegg | hsa05167 | Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05203 | Viral carcinogenesis - Homo sapiens (human) |
| wikipathways | WP1528 | Physiological and Pathological Hypertrophy of the Heart |
| wikipathways | WP1544 | MicroRNAs in cardiomyocyte hypertrophy |
| wikipathways | WP2332 | Interleukin-11 Signaling Pathway |
| wikipathways | WP236 | Adipogenesis |
| wikipathways | WP2374 | Oncostatin M Signaling Pathway |
| wikipathways | WP2815 | Mammary gland development pathway - Involution (Stage 4 of 4) |
| wikipathways | WP364 | IL-6 signaling pathway |
| wikipathways | WP3931 | ESC Pluripotency Pathways |
| wikipathways | WP615 | Senescence and Autophagy in Cancer |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD300 | Tozasertib | 1 |
| iGMDRD246 | NPC26 | 3 |
| iGMDRD872 | BRD7137 | 3 |
| iGMDRD366 | PI-103 | 1 |
| iGMDRD434 | BMS-536924 | 3 |
| iGMDRD77 | Itraconazole | 3 |
| iGMDRD220 | fumonisin B1 | 3 |
| iGMDRD137 | Indisulam | 3 |
| iGMDRD901 | ELCPK | 3 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD341 | Triacsin c | 1 |
| iGMDRD351 | GW843682X | 2 |
| iGMDRD150 | RITA | 10 |
| iGMDRD79 | Gemcitabine | 3 |
| iGMDRD307 | Manumycin A | 3 |
| iGMDRD148 | Pifithrin-mu | 3 |
| iGMDRD690 | PRIMA-1MET | 3 |
| iGMDRD64 | Parbendazole | 3 |
| iGMDRD188 | Piperlongumine | 5 |
| iGMDRD577 | BIX01294 | 2 |
| iGMDRD506 | Fedratinib | 4 |
| iGMDRD562 | Navitoclax | 3 |
| iGMDRD782 | DC-45-A2 | 2 |
| iGMDRD474 | Avrainvillamide | 4 |
| iGMDRD255 | SB225002 | 7 |
| iGMDRD394 | BX-795 | 1 |
| iGMDRD679 | Bistramide A | 5 |
| iGMDRD634 | SCHEMBL2608041 | 4 |
| iGMDRD446 | LY 2183240 | 4 |
| iGMDRD61 | Kinetin riboside | 1 |
| iGMDRD193 | Fqi1 | 3 |
| iGMDRD427 | ABT737 | 1 |
| iGMDRD144 | NSC95397 | 5 |
| iGMDRD781 | Sirolimus | 3 |
| iGMDRD126 | Tipifarnib | 8 |
| iGMDRD889 | Compound 7d-cis | 2 |
| iGMDRD1008 | SR-II-138A | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in IL6ST
CLASSFICATION
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