iGMDRD300


Canonical SMILES: CC1=CC(=NN1)NC2=NC(=NC(=C2)N3CCN(CC3)C)SC4=CC=C(C=C4)NC(=O)C5CC5

InChI: InChI=1S/C23H28N8OS/c1-15-13-20(29-28-15)25-19-14-21(31-11-9-30(2)10-12-31)27-23(26-19)33-18-7-5-17(6-8-18)24-22(32)16-3-4-16/h5-8,13-14,16H,3-4,9-12H2,1-2H3,(H,24,32)(H2,25,26,27,28,29)

InChI Key: GCIKSSRWRFVXBI-UHFFFAOYSA-N

Standard NameCHEMBLPubchem CIDDrug StatusDrug Type
TozasertibCHEMBL572878 CHEMBL2105657 5494450AloneSmall Molecule


Drug Pathways:

Mitosis

Drug-model tissue-cancer distribution: Bubble Plot

Drug-gene pathway enrichments

Drug-gene GO enrichments

Drug-Gene: Aster Plot


Gene IDGene NameModel Num.
3696ITGB81
64901RANBP171
27125AFF43
4854NOTCH35
6664SOX113
10460TACC34
5296PIK3R23
5027P2RX75
10903MTMR113
1464CSPG43
23085ERC12
6491STIL3
21ABCA33
132ADK3
3383ICAM11
6774STAT35
7161TP734
4926NUMA12
29101SSU721
2048EPHB23
114801TMEM200A1
8929PHOX2B3
10806SDCCAG81
2956MSH64
4303FOXO42
150465TTL3
4477MSMB2
1520CTSS5
57554LRRC72
347365ITIH64
3845KRAS2
4750NEK11
5295PIK3R12
2100ESR21
8289ARID1A3
80070ADAMTS209
25913POT11
701BUB1B5
3939LDHA1
2335FN15
53616ADAM224
3431SP1108
81035COLEC123
9869SETDB15
11160ERLIN21
10395DLC13
5241PGR3
353345GPR1419
79820CATSPERB3
56776FMN23
10892MALT15
4771NF21
23235SIK26
4170MCL12
23213SULF11
5218CDK143
22853LMTK21
7253TSHR3
8749ADAM181
3841KPNA52
2241FER2
1404HAPLN12
9816URB26
5154PDGFA6
6455SH3GL13
140469MYO3B2
114908TMEM1234
79934COQ8B1
7080NKX2-110
51199NIN3
202374STK32A4
1387CREBBP4
1893ECM13
9232PTTG13
2043EPHA43
8844KSR19
5788PTPRC2
23225NUP2104
2313FLI13
56164STK315
10013HDAC64
7133TNFRSF1B5
10178TENM14
9699RIMS22
1111CHEK13
26576SRPK32
2977GUCY1A23
11122PTPRT4
23617TSSK23
9024BRSK26
7173TPO6
5605MAP2K23
139378ADGRG42
7158TP53BP11
974CD79B3
2033EP3001
54567DLL42
8784TNFRSF187
4001LMNB12
83439TCF7L11
10006ABI13
7852CXCR43
284521OR2L133
4610MYCL5
5743PTGS28
51776MAP3K203
152137CCDC502
1880GPR1835
9693RAPGEF210
646643SBK23
6418SET3
222484LNX23
3927LASP15
3714JAG23
3556IL1RAP7
2242FES6
10342TFG3
3645INSRR3
22984PDCD116
9175MAP3K135
5468PPARG5
8313AXIN23
6733SRPK23
2042EPHA31
4792NFKBIA10
116986AGAP22
5330PLCB23
23255MTCL16
730249ACOD16
4216MAP3K41
5601MAPK93
269AMHR22
55681SCYL23
1992SERPINB14
399979SNX193
375449MAST41
7428VHL3
2064ERBB23
85443DCLK31
6850SYK3
57476GRAMD1B2
83983TSSK61
65217PCDH153
23387SIK33
783CACNB22
6416MAP2K42
9759HDAC42
8714ABCC33
1973EIF4A13
158056MAMDC44
2068ERCC22
5591PRKDC1
5568PRKACG3
6037RNASE32
9472AKAP61
54437SEMA5B3
2778GNAS2
130497OSR11
6917TCEA12
472ATM10
8945BTRC3
1009CDH112
139285AMER17
8148TAF156
53942CNTN512
84433CARD113
4804NGFR3
4058LTK3
54986ULK44
1123CHN16
1496CTNNA22
7010TEK4
5450POU2AF15
898CCNE17
2066ERBB42
8798DYRK41
839CASP63
5327PLAT5
51517NCKIPSD6
2201FBN27
1029CDKN2A1
7184HSP90B13
10062NR1H32
139728PNCK2
57523NYNRIN6
3236HOXD102
11143KAT76
7157TP533
7704ZBTB162
79058ASPSCR13
10114HIPK33
114788CSMD32
84513PLPP53
2263FGFR23
225689MAPK152
106480993RN7SL263P3
8408ULK13
9639ARHGEF103
1019CDK43
11213IRAK32
9967THRAP32
1045CDX21
4869NPM11
64386MMP253
344387CDKL43
863CBFA2T33
8874ARHGEF73
5600MAPK116
7038TG3
369ARAF3
4921DDR23
8660IRS23
3572IL6ST1
2177FANCD25
3187HNRNPH13
55589BMP2K3
57591MRTFA3
4436MSH22
652BMP48
6535SLC6A81
676BRDT3
5650KLK73
5871MAP4K210
9401RECQL43
2000ELF42
23365ARHGEF125
57578UNC792
4026LPP11
8997KALRN6
4437MSH31
2071ERCC36
57551TAOK11
2175FANCA3
23469PHF34
170692ADAMTS188
6654SOS14
672BRCA12
2060EPS153
2737GLI32
7204TRIO2
256536TCERG1L2
9252RPS6KA53
10733PLK43
5727PTCH12
546ATRX4
5606MAP2K37
5069PAPPA3
3558IL23
286133SCARA53
4214MAP3K13
8731RNMT5
1198CLK33
9972NUP1535
3239HOXD139
2187FANCB1
50615IL21R1
84823LMNB23
5290PIK3CA1
92335STRADA3
4145MATK9
1687GSDME3
26524LATS22
6391SDHC3
2318FLNC9
10565ARFGEF12
64919BCL11B8
57154SMURF16
607BCL93
10155TRIM283
1017CDK23
1956EGFR1
157680VPS13B3
2735GLI14
3065HDAC11
4609MYC8
64333ARHGAP91
64750SMURF22
3308HSPA43
5789PTPRD3
5599MAPK83
8021NUP2143
10461MERTK2
26278SACS5
896CCND34
29951PDZRN44
6446SGK11
1594CYP27B12
2189FANCG5
3635INPP5D3
1653DDX13
8900CCNA14
5187PER13
375056MIA32
10971YWHAQ4
10000AKT33
93627TBCK2
27330RPS6KA62
7189TRAF67
3949LDLR3
10186LHFPL61
673BRAF2
7153TOP2A3
1213CLTC2
84879MFSD2A5
3315HSPB13
23532PRAME2
780DDR13
5598MAPK79
65268WNK24
6095RORA7
29844TFPT3
146057TTBK23
4968OGG12
5205ATP8B12
8626TP631
5294PIK3CG5
1024CDK83
5979RET6
664BNIP34
4853NOTCH23
9509ADAMTS23
5563PRKAA26
10010TANK2
8312AXIN12
23476BRD43
57521RPTOR6
208AKT29
51592TRIM331
5595MAPK32
667DST2
23281MTUS26
4004LMO13
284086NEK82
1613DAPK31
3429IFI271
140803TRPM63
4317MMP82
2648KAT2A2
10962MLLT116
6009RHEB3
1676DFFA6
2870GRK66
3899AFF33
28954REM12
1445CSK5
79834PEAK11
2119ETV56
10257ABCC45
23389MED13L2
8028MLLT103
54904NSD37
387RHOA2
29941PKN39
221895JAZF13
1662DDX103
10076PTPRU6
7248TSC12
332BIRC52
5581PRKCE4
317APAF13
2690GHR4
9021SOCS38
100124696TEC1
9223MAGI11
860RUNX22
55289ACOXL6
3181HNRNPA2B13
9659PDE4DIP2
9201DCLK12
7293TNFRSF46
2049EPHB33
283455KSR23
6093ROCK12
2130EWSR12
2213FCGR2B3
3579CXCR21
5587PRKD11
5170PDPK15
2304FOXE12
23139MAST23
22982DIP2C1
5506PPP1R3A3
3709ITPR22
57147SCYL33
8899PRPF4B2
4067LYN2
150094SIK14
8428STK246
51562MBIP7
6300MAPK123
3516RBPJ3
7112TMPO3
4261CIITA3
3656IRAK22
4330MN13
84072HORMAD18
444ASPH3
11076TPPP5
7913DEK2
8536CAMK16
3662IRF42
9212AURKB3
2903GRIN2A2
5925RB14
4217MAP3K52
2074ERCC62
3691ITGB45
54790TET28
8717TRADD3
4302MLLT63
197259MLKL2
5586PKN21
7040TGFB12
30849PIK3R42
9878TOX42
3488IGFBP52
3480IGF1R1
79728PALB22
10494STK252
4299AFF15
9262STK17B3
2261FGFR34
865CBFB3
5567PRKACB2
3092HIP11
54518APBB1IP3
4763NF11
1612DAPK12
5260PHKG11
55791LRIF12
4613MYCN9
63893UBE2O2
1840DTX11
440270GOLGA8B1
5288PIK3C2G2
57096RPGRIP13
94ACVRL13
5287PIK3C2B4
23031MAST31
4593MUSK3
4629MYH113
3679ITGA75
6943TCF213
1608DGKG3
6868ADAM172
23112TNRC6B1
83732RIOK12
5885RAD213
1499CTNNB14
56155TEX143
2892GRIA32
1436CSF1R6
4916NTRK33
1795DOCK32
11035RIPK33
5624PROC5
5970RELA3

Gene in drug-gene network: Network Plot

Models in Tozasertib

​​​​