iGMDRD300
| Standard Name | CHEMBL | Pubchem CID | Drug Status | Drug Type |
|---|---|---|---|---|
| Tozasertib | CHEMBL572878 CHEMBL2105657 | 5494450 | Alone | Small Molecule |
Drug Pathways:
MitosisDrug-model tissue-cancer distribution: Bubble Plot
Drug-gene pathway enrichments
Drug-gene GO enrichments
Drug-Gene: Aster Plot
| Gene ID | Gene Name | Model Num. |
|---|---|---|
| 3696 | ITGB8 | 1 |
| 64901 | RANBP17 | 1 |
| 27125 | AFF4 | 3 |
| 4854 | NOTCH3 | 5 |
| 6664 | SOX11 | 3 |
| 10460 | TACC3 | 4 |
| 5296 | PIK3R2 | 3 |
| 5027 | P2RX7 | 5 |
| 10903 | MTMR11 | 3 |
| 1464 | CSPG4 | 3 |
| 23085 | ERC1 | 2 |
| 6491 | STIL | 3 |
| 21 | ABCA3 | 3 |
| 132 | ADK | 3 |
| 3383 | ICAM1 | 1 |
| 6774 | STAT3 | 5 |
| 7161 | TP73 | 4 |
| 4926 | NUMA1 | 2 |
| 29101 | SSU72 | 1 |
| 2048 | EPHB2 | 3 |
| 114801 | TMEM200A | 1 |
| 8929 | PHOX2B | 3 |
| 10806 | SDCCAG8 | 1 |
| 2956 | MSH6 | 4 |
| 4303 | FOXO4 | 2 |
| 150465 | TTL | 3 |
| 4477 | MSMB | 2 |
| 1520 | CTSS | 5 |
| 57554 | LRRC7 | 2 |
| 347365 | ITIH6 | 4 |
| 3845 | KRAS | 2 |
| 4750 | NEK1 | 1 |
| 5295 | PIK3R1 | 2 |
| 2100 | ESR2 | 1 |
| 8289 | ARID1A | 3 |
| 80070 | ADAMTS20 | 9 |
| 25913 | POT1 | 1 |
| 701 | BUB1B | 5 |
| 3939 | LDHA | 1 |
| 2335 | FN1 | 5 |
| 53616 | ADAM22 | 4 |
| 3431 | SP110 | 8 |
| 81035 | COLEC12 | 3 |
| 9869 | SETDB1 | 5 |
| 11160 | ERLIN2 | 1 |
| 10395 | DLC1 | 3 |
| 5241 | PGR | 3 |
| 353345 | GPR141 | 9 |
| 79820 | CATSPERB | 3 |
| 56776 | FMN2 | 3 |
| 10892 | MALT1 | 5 |
| 4771 | NF2 | 1 |
| 23235 | SIK2 | 6 |
| 4170 | MCL1 | 2 |
| 23213 | SULF1 | 1 |
| 5218 | CDK14 | 3 |
| 22853 | LMTK2 | 1 |
| 7253 | TSHR | 3 |
| 8749 | ADAM18 | 1 |
| 3841 | KPNA5 | 2 |
| 2241 | FER | 2 |
| 1404 | HAPLN1 | 2 |
| 9816 | URB2 | 6 |
| 5154 | PDGFA | 6 |
| 6455 | SH3GL1 | 3 |
| 140469 | MYO3B | 2 |
| 114908 | TMEM123 | 4 |
| 79934 | COQ8B | 1 |
| 7080 | NKX2-1 | 10 |
| 51199 | NIN | 3 |
| 202374 | STK32A | 4 |
| 1387 | CREBBP | 4 |
| 1893 | ECM1 | 3 |
| 9232 | PTTG1 | 3 |
| 2043 | EPHA4 | 3 |
| 8844 | KSR1 | 9 |
| 5788 | PTPRC | 2 |
| 23225 | NUP210 | 4 |
| 2313 | FLI1 | 3 |
| 56164 | STK31 | 5 |
| 10013 | HDAC6 | 4 |
| 7133 | TNFRSF1B | 5 |
| 10178 | TENM1 | 4 |
| 9699 | RIMS2 | 2 |
| 1111 | CHEK1 | 3 |
| 26576 | SRPK3 | 2 |
| 2977 | GUCY1A2 | 3 |
| 11122 | PTPRT | 4 |
| 23617 | TSSK2 | 3 |
| 9024 | BRSK2 | 6 |
| 7173 | TPO | 6 |
| 5605 | MAP2K2 | 3 |
| 139378 | ADGRG4 | 2 |
| 7158 | TP53BP1 | 1 |
| 974 | CD79B | 3 |
| 2033 | EP300 | 1 |
| 54567 | DLL4 | 2 |
| 8784 | TNFRSF18 | 7 |
| 4001 | LMNB1 | 2 |
| 83439 | TCF7L1 | 1 |
| 10006 | ABI1 | 3 |
| 7852 | CXCR4 | 3 |
| 284521 | OR2L13 | 3 |
| 4610 | MYCL | 5 |
| 5743 | PTGS2 | 8 |
| 51776 | MAP3K20 | 3 |
| 152137 | CCDC50 | 2 |
| 1880 | GPR183 | 5 |
| 9693 | RAPGEF2 | 10 |
| 646643 | SBK2 | 3 |
| 6418 | SET | 3 |
| 222484 | LNX2 | 3 |
| 3927 | LASP1 | 5 |
| 3714 | JAG2 | 3 |
| 3556 | IL1RAP | 7 |
| 2242 | FES | 6 |
| 10342 | TFG | 3 |
| 3645 | INSRR | 3 |
| 22984 | PDCD11 | 6 |
| 9175 | MAP3K13 | 5 |
| 5468 | PPARG | 5 |
| 8313 | AXIN2 | 3 |
| 6733 | SRPK2 | 3 |
| 2042 | EPHA3 | 1 |
| 4792 | NFKBIA | 10 |
| 116986 | AGAP2 | 2 |
| 5330 | PLCB2 | 3 |
| 23255 | MTCL1 | 6 |
| 730249 | ACOD1 | 6 |
| 4216 | MAP3K4 | 1 |
| 5601 | MAPK9 | 3 |
| 269 | AMHR2 | 2 |
| 55681 | SCYL2 | 3 |
| 1992 | SERPINB1 | 4 |
| 399979 | SNX19 | 3 |
| 375449 | MAST4 | 1 |
| 7428 | VHL | 3 |
| 2064 | ERBB2 | 3 |
| 85443 | DCLK3 | 1 |
| 6850 | SYK | 3 |
| 57476 | GRAMD1B | 2 |
| 83983 | TSSK6 | 1 |
| 65217 | PCDH15 | 3 |
| 23387 | SIK3 | 3 |
| 783 | CACNB2 | 2 |
| 6416 | MAP2K4 | 2 |
| 9759 | HDAC4 | 2 |
| 8714 | ABCC3 | 3 |
| 1973 | EIF4A1 | 3 |
| 158056 | MAMDC4 | 4 |
| 2068 | ERCC2 | 2 |
| 5591 | PRKDC | 1 |
| 5568 | PRKACG | 3 |
| 6037 | RNASE3 | 2 |
| 9472 | AKAP6 | 1 |
| 54437 | SEMA5B | 3 |
| 2778 | GNAS | 2 |
| 130497 | OSR1 | 1 |
| 6917 | TCEA1 | 2 |
| 472 | ATM | 10 |
| 8945 | BTRC | 3 |
| 1009 | CDH11 | 2 |
| 139285 | AMER1 | 7 |
| 8148 | TAF15 | 6 |
| 53942 | CNTN5 | 12 |
| 84433 | CARD11 | 3 |
| 4804 | NGFR | 3 |
| 4058 | LTK | 3 |
| 54986 | ULK4 | 4 |
| 1123 | CHN1 | 6 |
| 1496 | CTNNA2 | 2 |
| 7010 | TEK | 4 |
| 5450 | POU2AF1 | 5 |
| 898 | CCNE1 | 7 |
| 2066 | ERBB4 | 2 |
| 8798 | DYRK4 | 1 |
| 839 | CASP6 | 3 |
| 5327 | PLAT | 5 |
| 51517 | NCKIPSD | 6 |
| 2201 | FBN2 | 7 |
| 1029 | CDKN2A | 1 |
| 7184 | HSP90B1 | 3 |
| 10062 | NR1H3 | 2 |
| 139728 | PNCK | 2 |
| 57523 | NYNRIN | 6 |
| 3236 | HOXD10 | 2 |
| 11143 | KAT7 | 6 |
| 7157 | TP53 | 3 |
| 7704 | ZBTB16 | 2 |
| 79058 | ASPSCR1 | 3 |
| 10114 | HIPK3 | 3 |
| 114788 | CSMD3 | 2 |
| 84513 | PLPP5 | 3 |
| 2263 | FGFR2 | 3 |
| 225689 | MAPK15 | 2 |
| 106480993 | RN7SL263P | 3 |
| 8408 | ULK1 | 3 |
| 9639 | ARHGEF10 | 3 |
| 1019 | CDK4 | 3 |
| 11213 | IRAK3 | 2 |
| 9967 | THRAP3 | 2 |
| 1045 | CDX2 | 1 |
| 4869 | NPM1 | 1 |
| 64386 | MMP25 | 3 |
| 344387 | CDKL4 | 3 |
| 863 | CBFA2T3 | 3 |
| 8874 | ARHGEF7 | 3 |
| 5600 | MAPK11 | 6 |
| 7038 | TG | 3 |
| 369 | ARAF | 3 |
| 4921 | DDR2 | 3 |
| 8660 | IRS2 | 3 |
| 3572 | IL6ST | 1 |
| 2177 | FANCD2 | 5 |
| 3187 | HNRNPH1 | 3 |
| 55589 | BMP2K | 3 |
| 57591 | MRTFA | 3 |
| 4436 | MSH2 | 2 |
| 652 | BMP4 | 8 |
| 6535 | SLC6A8 | 1 |
| 676 | BRDT | 3 |
| 5650 | KLK7 | 3 |
| 5871 | MAP4K2 | 10 |
| 9401 | RECQL4 | 3 |
| 2000 | ELF4 | 2 |
| 23365 | ARHGEF12 | 5 |
| 57578 | UNC79 | 2 |
| 4026 | LPP | 11 |
| 8997 | KALRN | 6 |
| 4437 | MSH3 | 1 |
| 2071 | ERCC3 | 6 |
| 57551 | TAOK1 | 1 |
| 2175 | FANCA | 3 |
| 23469 | PHF3 | 4 |
| 170692 | ADAMTS18 | 8 |
| 6654 | SOS1 | 4 |
| 672 | BRCA1 | 2 |
| 2060 | EPS15 | 3 |
| 2737 | GLI3 | 2 |
| 7204 | TRIO | 2 |
| 256536 | TCERG1L | 2 |
| 9252 | RPS6KA5 | 3 |
| 10733 | PLK4 | 3 |
| 5727 | PTCH1 | 2 |
| 546 | ATRX | 4 |
| 5606 | MAP2K3 | 7 |
| 5069 | PAPPA | 3 |
| 3558 | IL2 | 3 |
| 286133 | SCARA5 | 3 |
| 4214 | MAP3K1 | 3 |
| 8731 | RNMT | 5 |
| 1198 | CLK3 | 3 |
| 9972 | NUP153 | 5 |
| 3239 | HOXD13 | 9 |
| 2187 | FANCB | 1 |
| 50615 | IL21R | 1 |
| 84823 | LMNB2 | 3 |
| 5290 | PIK3CA | 1 |
| 92335 | STRADA | 3 |
| 4145 | MATK | 9 |
| 1687 | GSDME | 3 |
| 26524 | LATS2 | 2 |
| 6391 | SDHC | 3 |
| 2318 | FLNC | 9 |
| 10565 | ARFGEF1 | 2 |
| 64919 | BCL11B | 8 |
| 57154 | SMURF1 | 6 |
| 607 | BCL9 | 3 |
| 10155 | TRIM28 | 3 |
| 1017 | CDK2 | 3 |
| 1956 | EGFR | 1 |
| 157680 | VPS13B | 3 |
| 2735 | GLI1 | 4 |
| 3065 | HDAC1 | 1 |
| 4609 | MYC | 8 |
| 64333 | ARHGAP9 | 1 |
| 64750 | SMURF2 | 2 |
| 3308 | HSPA4 | 3 |
| 5789 | PTPRD | 3 |
| 5599 | MAPK8 | 3 |
| 8021 | NUP214 | 3 |
| 10461 | MERTK | 2 |
| 26278 | SACS | 5 |
| 896 | CCND3 | 4 |
| 29951 | PDZRN4 | 4 |
| 6446 | SGK1 | 1 |
| 1594 | CYP27B1 | 2 |
| 2189 | FANCG | 5 |
| 3635 | INPP5D | 3 |
| 1653 | DDX1 | 3 |
| 8900 | CCNA1 | 4 |
| 5187 | PER1 | 3 |
| 375056 | MIA3 | 2 |
| 10971 | YWHAQ | 4 |
| 10000 | AKT3 | 3 |
| 93627 | TBCK | 2 |
| 27330 | RPS6KA6 | 2 |
| 7189 | TRAF6 | 7 |
| 3949 | LDLR | 3 |
| 10186 | LHFPL6 | 1 |
| 673 | BRAF | 2 |
| 7153 | TOP2A | 3 |
| 1213 | CLTC | 2 |
| 84879 | MFSD2A | 5 |
| 3315 | HSPB1 | 3 |
| 23532 | PRAME | 2 |
| 780 | DDR1 | 3 |
| 5598 | MAPK7 | 9 |
| 65268 | WNK2 | 4 |
| 6095 | RORA | 7 |
| 29844 | TFPT | 3 |
| 146057 | TTBK2 | 3 |
| 4968 | OGG1 | 2 |
| 5205 | ATP8B1 | 2 |
| 8626 | TP63 | 1 |
| 5294 | PIK3CG | 5 |
| 1024 | CDK8 | 3 |
| 5979 | RET | 6 |
| 664 | BNIP3 | 4 |
| 4853 | NOTCH2 | 3 |
| 9509 | ADAMTS2 | 3 |
| 5563 | PRKAA2 | 6 |
| 10010 | TANK | 2 |
| 8312 | AXIN1 | 2 |
| 23476 | BRD4 | 3 |
| 57521 | RPTOR | 6 |
| 208 | AKT2 | 9 |
| 51592 | TRIM33 | 1 |
| 5595 | MAPK3 | 2 |
| 667 | DST | 2 |
| 23281 | MTUS2 | 6 |
| 4004 | LMO1 | 3 |
| 284086 | NEK8 | 2 |
| 1613 | DAPK3 | 1 |
| 3429 | IFI27 | 1 |
| 140803 | TRPM6 | 3 |
| 4317 | MMP8 | 2 |
| 2648 | KAT2A | 2 |
| 10962 | MLLT11 | 6 |
| 6009 | RHEB | 3 |
| 1676 | DFFA | 6 |
| 2870 | GRK6 | 6 |
| 3899 | AFF3 | 3 |
| 28954 | REM1 | 2 |
| 1445 | CSK | 5 |
| 79834 | PEAK1 | 1 |
| 2119 | ETV5 | 6 |
| 10257 | ABCC4 | 5 |
| 23389 | MED13L | 2 |
| 8028 | MLLT10 | 3 |
| 54904 | NSD3 | 7 |
| 387 | RHOA | 2 |
| 29941 | PKN3 | 9 |
| 221895 | JAZF1 | 3 |
| 1662 | DDX10 | 3 |
| 10076 | PTPRU | 6 |
| 7248 | TSC1 | 2 |
| 332 | BIRC5 | 2 |
| 5581 | PRKCE | 4 |
| 317 | APAF1 | 3 |
| 2690 | GHR | 4 |
| 9021 | SOCS3 | 8 |
| 100124696 | TEC | 1 |
| 9223 | MAGI1 | 1 |
| 860 | RUNX2 | 2 |
| 55289 | ACOXL | 6 |
| 3181 | HNRNPA2B1 | 3 |
| 9659 | PDE4DIP | 2 |
| 9201 | DCLK1 | 2 |
| 7293 | TNFRSF4 | 6 |
| 2049 | EPHB3 | 3 |
| 283455 | KSR2 | 3 |
| 6093 | ROCK1 | 2 |
| 2130 | EWSR1 | 2 |
| 2213 | FCGR2B | 3 |
| 3579 | CXCR2 | 1 |
| 5587 | PRKD1 | 1 |
| 5170 | PDPK1 | 5 |
| 2304 | FOXE1 | 2 |
| 23139 | MAST2 | 3 |
| 22982 | DIP2C | 1 |
| 5506 | PPP1R3A | 3 |
| 3709 | ITPR2 | 2 |
| 57147 | SCYL3 | 3 |
| 8899 | PRPF4B | 2 |
| 4067 | LYN | 2 |
| 150094 | SIK1 | 4 |
| 8428 | STK24 | 6 |
| 51562 | MBIP | 7 |
| 6300 | MAPK12 | 3 |
| 3516 | RBPJ | 3 |
| 7112 | TMPO | 3 |
| 4261 | CIITA | 3 |
| 3656 | IRAK2 | 2 |
| 4330 | MN1 | 3 |
| 84072 | HORMAD1 | 8 |
| 444 | ASPH | 3 |
| 11076 | TPPP | 5 |
| 7913 | DEK | 2 |
| 8536 | CAMK1 | 6 |
| 3662 | IRF4 | 2 |
| 9212 | AURKB | 3 |
| 2903 | GRIN2A | 2 |
| 5925 | RB1 | 4 |
| 4217 | MAP3K5 | 2 |
| 2074 | ERCC6 | 2 |
| 3691 | ITGB4 | 5 |
| 54790 | TET2 | 8 |
| 8717 | TRADD | 3 |
| 4302 | MLLT6 | 3 |
| 197259 | MLKL | 2 |
| 5586 | PKN2 | 1 |
| 7040 | TGFB1 | 2 |
| 30849 | PIK3R4 | 2 |
| 9878 | TOX4 | 2 |
| 3488 | IGFBP5 | 2 |
| 3480 | IGF1R | 1 |
| 79728 | PALB2 | 2 |
| 10494 | STK25 | 2 |
| 4299 | AFF1 | 5 |
| 9262 | STK17B | 3 |
| 2261 | FGFR3 | 4 |
| 865 | CBFB | 3 |
| 5567 | PRKACB | 2 |
| 3092 | HIP1 | 1 |
| 54518 | APBB1IP | 3 |
| 4763 | NF1 | 1 |
| 1612 | DAPK1 | 2 |
| 5260 | PHKG1 | 1 |
| 55791 | LRIF1 | 2 |
| 4613 | MYCN | 9 |
| 63893 | UBE2O | 2 |
| 1840 | DTX1 | 1 |
| 440270 | GOLGA8B | 1 |
| 5288 | PIK3C2G | 2 |
| 57096 | RPGRIP1 | 3 |
| 94 | ACVRL1 | 3 |
| 5287 | PIK3C2B | 4 |
| 23031 | MAST3 | 1 |
| 4593 | MUSK | 3 |
| 4629 | MYH11 | 3 |
| 3679 | ITGA7 | 5 |
| 6943 | TCF21 | 3 |
| 1608 | DGKG | 3 |
| 6868 | ADAM17 | 2 |
| 23112 | TNRC6B | 1 |
| 83732 | RIOK1 | 2 |
| 5885 | RAD21 | 3 |
| 1499 | CTNNB1 | 4 |
| 56155 | TEX14 | 3 |
| 2892 | GRIA3 | 2 |
| 1436 | CSF1R | 6 |
| 4916 | NTRK3 | 3 |
| 1795 | DOCK3 | 2 |
| 11035 | RIPK3 | 3 |
| 5624 | PROC | 5 |
| 5970 | RELA | 3 |
Gene in drug-gene network: Network Plot
Models in Tozasertib
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.