YWHAQ

Summary: This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse and rat orthologs. This gene is upregulated in patients with amyotrophic lateral sclerosis. It contains in its 5' UTR a 6 bp tandem repeat sequence which is polymorphic, however, there is no correlation between the repeat number and the disease. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Nametyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
OMIM IDMIM:609009
Ensembl IDEnsembl:ENSG00000134308
HGNC IDHGNC:HGNC:12854
PHARMGKB IDPA37443
Map Location2p25.1

GO terms in YWHAQ


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Term Type
Evidence Type
GO Term ID
GO Des.
CC IDA GO:0005737 cytoplasm
CC IEA GO:0005739 mitochondrion
CC TAS GO:0005829 cytosol
CC HDA GO:0005925 focal adhesion
CC HDA GO:0016020 membrane
CC IDA GO:0032991 protein-containing complex
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Gene expression in normal tissue: YWHAQ

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 39BLOOtissue: BLOO cancer: BLOOD model num: 0BLOODtissue: BLOOD cancer: undefined model num: 29

Gene-drug pathway distribution

undefined11Mitosis1ERK MAPK signaling1Apoptosis regulation1Longevity regulating pathway1

Pathways in YWHAQ


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Database
Pathway ID
Pathway Des.
reactome R-HSA-109581 Apoptosis
reactome R-HSA-109606 Intrinsic Pathway for Apoptosis
reactome R-HSA-111447 Activation of BAD and translocation to mitochondria
reactome R-HSA-114452 Activation of BH3-only proteins
reactome R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane
reactome R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD579 PF750 5
iGMDRD126 Tipifarnib 7
iGMDRD137 Indisulam 4
iGMDRD885 Compound 110 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in YWHAQ

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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