YWHAQ


Summary: This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse and rat orthologs. This gene is upregulated in patients with amyotrophic lateral sclerosis. It contains in its 5' UTR a 6 bp tandem repeat sequence which is polymorphic, however, there is no correlation between the repeat number and the disease. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein thetaMIM:609009Ensembl:ENSG00000134308HGNC:HGNC:12854PA374432p25.1

GO terms in YWHAQ


Term TypeEvidence TypeGO Term IDGO Des.
CCIDAGO:0005737cytoplasm
CCIEAGO:0005739mitochondrion
CCTASGO:0005829cytosol
CCHDAGO:0005925focal adhesion
CCHDAGO:0016020membrane
CCIDAGO:0032991protein-containing complex
CCHDAGO:0070062extracellular exosome
BPHEPGO:0021762substantia nigra development
BPIDAGO:0045892negative regulation of transcription, DNA-templated
BPTASGO:0061024membrane organization
BPTASGO:1900740positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
MFIPIGO:0005515protein binding
MFIEAGO:0019904protein domain specific binding
MFIPIGO:0042802identical protein binding
MFIPIGO:0047485protein N-terminus binding

Gene expression in normal tissue: YWHAQ

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in YWHAQ


DatabasePathway IDPathway Des.
reactomeR-HSA-109581Apoptosis
reactomeR-HSA-109606Intrinsic Pathway for Apoptosis
reactomeR-HSA-111447Activation of BAD and translocation to mitochondria
reactomeR-HSA-114452Activation of BH3-only proteins
reactomeR-HSA-1445148Translocation of SLC2A4 (GLUT4) to the plasma membrane
reactomeR-HSA-1445148Translocation of SLC2A4 (GLUT4) to the plasma membrane
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-1640170Cell Cycle
reactomeR-HSA-194315Signaling by Rho GTPases
reactomeR-HSA-195258RHO GTPase Effectors
reactomeR-HSA-199991Membrane Trafficking
reactomeR-HSA-199991Membrane Trafficking
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-3700989Transcriptional Regulation by TP53
reactomeR-HSA-5357801Programmed Cell Death
reactomeR-HSA-5625740RHO GTPases activate PKNs
reactomeR-HSA-5628897TP53 Regulates Metabolic Genes
reactomeR-HSA-5653656Vesicle-mediated transport
reactomeR-HSA-5653656Vesicle-mediated transport
reactomeR-HSA-69473G2/M DNA damage checkpoint
reactomeR-HSA-69481G2/M Checkpoints
reactomeR-HSA-69620Cell Cycle Checkpoints
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-75035Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
wikipathwaysWP179Cell Cycle
wikipathwaysWP2002miR-targeted genes in epithelium - TarBase
wikipathwaysWP2003miR-targeted genes in leukocytes - TarBase
wikipathwaysWP2004miR-targeted genes in lymphocytes - TarBase
wikipathwaysWP2005miR-targeted genes in muscle cell - TarBase
wikipathwaysWP2006miR-targeted genes in squamous cell - TarBase
wikipathwaysWP2272Pathogenic Escherichia coli infection
wikipathwaysWP2572Primary Focal Segmental Glomerulosclerosis FSGS
wikipathwaysWP286IL-3 Signaling Pathway
wikipathwaysWP289Myometrial Relaxation and Contraction Pathways
wikipathwaysWP536Calcium Regulation in the Cardiac Cell
wikipathwaysWP706Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways
pida6b1_a6b4_integrin_pathwaya6b1 and a6b4 Integrin signaling
pidbetacatenin_nuc_pathwayRegulation of nuclear beta catenin signaling and target gene transcription
piderbb1_downstream_pathwayErbB1 downstream signaling
pidfoxopathwayFoxO family signaling
pidinsulin_glucose_pathwayInsulin-mediated glucose transport
pidlkb1_pathwayLKB1 signaling events
pidmtor_4pathwaymTOR signaling pathway
pidnfat_3pathwayRole of Calcineurin-dependent NFAT signaling in lymphocytes
pidp38_mk2pathwayp38 signaling mediated by MAPKAP kinases
pidpdgfrbpathwayPDGFR-beta signaling pathway
pidpi3kciaktpathwayClass I PI3K signaling events mediated by Akt
pidpi3kplctrkpathwayTrk receptor signaling mediated by PI3K and PLC-gamma
pidtap63pathwayValidated transcriptional targets of TAp63 isoforms
kegghsa04110Cell cycle - Homo sapiens (human)
kegghsa04114Oocyte meiosis - Homo sapiens (human)
kegghsa04151PI3K-Akt signaling pathway - Homo sapiens (human)
kegghsa04390Hippo signaling pathway - Homo sapiens (human)
kegghsa05130Pathogenic Escherichia coli infection - Homo sapiens (human)
kegghsa05161Hepatitis B - Homo sapiens (human)
kegghsa05169Epstein-Barr virus infection - Homo sapiens (human)
kegghsa05203Viral carcinogenesis - Homo sapiens (human)
netpathPathway_Alpha6Beta4IntegrinAlpha6Beta4Integrin
netpathPathway_TCRTCR
netpathPathway_TNFalphaTNFalpha

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD579PF7505
iGMDRD126Tipifarnib7
iGMDRD137Indisulam4
iGMDRD885Compound 1103
iGMDRD781Sirolimus5
iGMDRD434BMS-5369243
iGMDRD577BIX012943
iGMDRD562Navitoclax8
iGMDRD219Bax channel blocker3
iGMDRD286Nsc 6328399
iGMDRD871BRD63683
iGMDRD367Ro 28-16753
iGMDRD399Selumetinib5
iGMDRD634SCHEMBL26080413
iGMDRD300Tozasertib4

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in YWHAQ

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