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iGMDRD126

Canonical SMILES: CN1C=NC=C1C(C2=CC=C(C=C2)Cl)(C3=CC4=C(C=C3)N(C(=O)C=C4C5=CC(=CC=C5)Cl)C)N

InChI: InChI=1S/C27H22Cl2N4O/c1-32-16-31-15-25(32)27(30,18-6-9-20(28)10-7-18)19-8-11-24-23(13-19)22(14-26(34)33(24)2)17-4-3-5-21(29)12-17/h3-16H,30H2,1-2H3/t27-/m1/s1

InChI Key: PLHJCIYEEKOWNM-HHHXNRCGSA-N

Standard Name	CHEMBL	Pubchem CID	DRUGBANK ID	Drug Status	Drug Type
Tipifarnib	CHEMBL289228	159324	DB04960	Alone	Small Molecule

Drug Class:

Antineoplastic Agents Heterocyclic Compounds Heterocyclic Compounds, 2-Ring P-glycoprotein/ABCB1 Inhibitors Quinolines

Drug Targets:

FNTA FNTB (P49356)

Drug-model tissue-cancer distribution: Bubble Plot

Drug-gene pathway enrichments

Drug-gene GO enrichments

Drug-Gene: Aster Plot

Gene ID	Gene Name	Model Num.
331	XIAP	2
64901	RANBP17	7
27102	EIF2AK1	3
27125	AFF4	3
4854	NOTCH3	3
7514	XPO1	2
8999	CDKL2	3
6664	SOX11	3
5027	P2RX7	6
10903	MTMR11	1
997	CDC34	3
79054	TRPM8	1
10221	TRIB1	3
10641	NPRL2	6
23085	ERC1	7
8444	DYRK3	3
10987	COPS5	1
21	ABCA3	2
6581	SLC22A3	3
132	ADK	4
3383	ICAM1	3
6774	STAT3	9
6195	RPS6KA1	6
6319	SCD	6
8476	CDC42BPA	3
11183	MAP4K5	3
2986	GUCY2F	1
2048	EPHB2	7
4168	MCF2	3
2956	MSH6	2
2200	FBN1	1
7171	TPM4	1
150465	TTL	3
1520	CTSS	5
57554	LRRC7	3
9706	ULK2	2
93	ACVR2B	2
347365	ITIH6	1
3845	KRAS	2
1138	CHRNA5	2
4750	NEK1	8
8289	ARID1A	7
80070	ADAMTS20	4
3939	LDHA	2
51231	VRK3	3
25778	DSTYK	1
84700	MYO18B	2
5593	PRKG2	2
3431	SP110	3
4352	MPL	3
6938	TCF12	4
2475	MTOR	4
9263	STK17A	2
9475	ROCK2	4
6597	SMARCA4	3
81035	COLEC12	3
9869	SETDB1	5
4036	LRP2	3
7764	ZNF217	2
11160	ERLIN2	2
10395	DLC1	6
353345	GPR141	2
5133	PDCD1	2
10320	IKZF1	1
79820	CATSPERB	3
7942	TFEB	7
390502	SERPINA2	4
5754	PTK7	2
5079	PAX5	8
64783	RBM15	9
10892	MALT1	3
4771	NF2	3
23235	SIK2	5
10863	ADAM28	3
4170	MCL1	3
1607	DGKB	4
3320	HSP90AA1	4
9641	IKBKE	3
3066	HDAC2	2
10142	AKAP9	3
22853	LMTK2	9
7253	TSHR	3
23310	NCAPD3	3
5298	PI4KB	3
27	ABL2	6
3841	KPNA5	3
2241	FER	2
341676	NEK5	5
1404	HAPLN1	2
22821	RASA3	4
2249	FGF4	1
577	ADGRB3	2
114783	LMTK3	1
202374	STK32A	7
1387	CREBBP	5
1893	ECM1	1
7555	CNBP	3
10454	TAB1	3
9232	PTTG1	3
2043	EPHA4	3
23225	NUP210	4
5579	PRKCB	4
5596	MAPK4	3
9411	ARHGAP29	4
8558	CDK10	3
29998	BICRA	2
1111	CHEK1	2
2977	GUCY1A2	7
10438	C1D	5
11122	PTPRT	2
27148	STK36	4
9024	BRSK2	2
55300	PI4K2B	4
2120	ETV6	3
5605	MAP2K2	3
51512	GTSE1	3
139378	ADGRG4	3
7158	TP53BP1	2
89910	UBE3B	2
974	CD79B	3
2033	EP300	3
8784	TNFRSF18	4
9578	CDC42BPB	2
641	BLM	2
64324	NSD1	3
4595	MUTYH	3
23522	KAT6B	2
3227	HOXC11	3
10006	ABI1	2
25925	ZNF521	3
7852	CXCR4	3
54477	PLEKHA5	2
57670	KIAA1549	6
837	CASP4	2
4301	AFDN	2
816	CAMK2B	2
84033	OBSCN	6
342667	STAC2	1
51776	MAP3K20	9
342977	NANOS3	2
2268	FGR	3
646643	SBK2	3
1586	CYP17A1	2
8549	LGR5	7
6256	RXRA	3
26353	HSPB8	4
64083	GOLPH3	1
22806	IKZF3	5
2242	FES	3
4005	LMO2	2
3645	INSRR	1
22984	PDCD11	5
9175	MAP3K13	1
200576	PIKFYVE	6
80351	TNKS2	2
1437	CSF2	2
8313	AXIN2	4
6733	SRPK2	5
6091	ROBO1	2
2260	FGFR1	3
5330	PLCB2	7
114548	NLRP3	3
730249	ACOD1	3
80129	CCDC170	6
10217	CTDSPL	1
4216	MAP3K4	5
29904	EEF2K	3
51804	SIX4	6
9098	USP6	2
269	AMHR2	2
83931	STK40	2
2045	EPHA7	4
23405	DICER1	8
1992	SERPINB1	2
375449	MAST4	5
4752	NEK3	3
57476	GRAMD1B	3
83983	TSSK6	2
8643	PTCH2	2
65217	PCDH15	3
993	CDC25A	2
5534	PPP3R1	3
4294	MAP3K10	2
1456	CSNK1G3	1
783	CACNB2	8
9759	HDAC4	2
8714	ABCC3	3
5286	PIK3C2A	2
8215	DVL1P1	2
5591	PRKDC	3
80312	TET1	3
5568	PRKACG	3
8091	HMGA2	3
659	BMPR2	2
6037	RNASE3	3
9472	AKAP6	2
157285	PRAG1	3
54437	SEMA5B	3
8515	ITGA10	2
2778	GNAS	8
9590	AKAP12	2
3685	ITGAV	3
6917	TCEA1	2
472	ATM	3
3418	IDH2	5
83903	HASPIN	2
8148	TAF15	9
28996	HIPK2	3
53942	CNTN5	2
5924	RASGRF2	8
84433	CARD11	4
9564	BCAR1	2
8038	ADAM12	2
4058	LTK	2
7010	TEK	4
5450	POU2AF1	7
898	CCNE1	3
23152	CIC	6
2272	FHIT	1
2066	ERBB4	1
839	CASP6	3
5863	RGL2	5
10290	SPEG	6
5108	PCM1	4
139728	PNCK	5
9794	MAML1	2
5129	CDK18	5
27436	EML4	4
8576	STK16	3
3236	HOXD10	2
5336	PLCG2	2
9874	TLK1	1
11143	KAT7	2
28514	DLL1	1
7157	TP53	2
2099	ESR1	2
6092	ROBO2	5
7704	ZBTB16	2
79058	ASPSCR1	3
6794	STK11	2
2322	FLT3	1
57194	ATP10A	2
25836	NIPBL	5
8218	CLTCL1	3
3791	KDR	5
114788	CSMD3	7
6184	RPN1	1
26281	FGF20	3
54498	SMOX	1
2263	FGFR2	1
2133	EXT3	3
106480993	RN7SL263P	3
5585	PKN1	2
7249	TSC2	1
1019	CDK4	3
65243	ZFP69B	2
9967	THRAP3	3
124540	MSI2	6
85481	PSKH2	6
8833	GMPS	7
5604	MAP2K1	6
4869	NPM1	4
64386	MMP25	3
344387	CDKL4	1
863	CBFA2T3	2
8874	ARHGEF7	5
1555	CYP2B6	5
51086	TNNI3K	2
1102	RCBTB2	8
9088	PKMYT1	3
5600	MAPK11	1
7038	TG	4
369	ARAF	5
3572	IL6ST	8
9965	FGF19	3
57105	CYSLTR2	2
65125	WNK1	1
57591	MRTFA	4
136332	LRGUK	2
4436	MSH2	3
652	BMP4	5
676	BRDT	3
1656	DDX6	5
7175	TPR	2
5871	MAP4K2	5
3718	JAK3	3
8115	TCL1A	3
2081	ERN1	3
84181	CHD6	3
4437	MSH3	5
8923202	COX2	1
2071	ERCC3	3
57551	TAOK1	4
6280	S100A9	4
23469	PHF3	2
4089	SMAD4	2
8288	EPX	3
6654	SOS1	8
1616	DAXX	4
2668	GDNF	3
4139	MARK1	5
7204	TRIO	5
256536	TCERG1L	2
139760	GPR119	3
78989	COLEC11	5
23373	CRTC1	8
5727	PTCH1	6
546	ATRX	4
3426	CFI	3
5606	MAP2K3	2
5297	PI4KA	2
5069	PAPPA	6
7786	MAP3K12	3
57144	PAK5	5
8216	LZTR1	3
3239	HOXD13	6
2187	FANCB	6
84823	LMNB2	3
5290	PIK3CA	3
3562	IL3	3
92335	STRADA	3
3720	JARID2	2
1687	GSDME	3
26524	LATS2	5
90	ACVR1	2
5366	PMAIP1	3
5045	FURIN	4
7043	TGFB3	7
10565	ARFGEF1	1
64919	BCL11B	4
5530	PPP3CA	2
675	BRCA2	3
10155	TRIM28	3
28958	COA3	3
7075	TIE1	3
1956	EGFR	9
157680	VPS13B	5
3065	HDAC1	4
4609	MYC	7
64333	ARHGAP9	2
11064	CNTRL	2
64750	SMURF2	4
90956	ADCK2	9
54206	ERRFI1	1
2624	GATA2	5
8021	NUP214	4
5155	PDGFB	4
8013	NR4A3	6
10461	MERTK	4
100130933	SMIM6	3
4684	NCAM1	2
26278	SACS	9
894	CCND2	2
5462	POU5F1B	3
896	CCND3	1
6776	STAT5A	2
51701	NLK	1
2189	FANCG	2
5156	PDGFRA	3
3635	INPP5D	8
7917	BAG6	5
375056	MIA3	5
10971	YWHAQ	7
1544	CYP1A2	3
91754	NEK9	2
93627	TBCK	3
27330	RPS6KA6	5
3949	LDLR	3
7015	TERT	1
10186	LHFPL6	1
57082	KNL1	3
1981	EIF4G1	2
1213	CLTC	2
1769	DNAH8	2
22976	PAXIP1	2
23532	PRAME	2
4863	NPAT	2
780	DDR1	3
83452	RAB33B	5
57538	ALPK3	4
8924	HERC2	7
2078	ERG	2
6502	SKP2	3
339345	NANOS2	4
65268	WNK2	2
79184	BRCC3	5
7027	TFDP1	3
867	CBL	1
6095	RORA	5
29844	TFPT	3
146057	TTBK2	5
57507	ZNF608	7
84441	MAML2	1
7301	TYRO3	3
5205	ATP8B1	2
8626	TP63	4
9113	LATS1	4
8178	ELL	3
9064	MAP3K6	3
5294	PIK3CG	3
1024	CDK8	3
4298	MLLT1	2
5979	RET	2
10253	SPRY2	2
9843	HEPH	3
664	BNIP3	6
4853	NOTCH2	2
162968	ZNF497	3
9509	ADAMTS2	3
266747	RGL4	2
23049	SMG1	3
10010	TANK	5
8312	AXIN1	5
23476	BRD4	7
208	AKT2	4
51592	TRIM33	9
7030	TFE3	8
140609	NEK7	3
8888	MCM3AP	4
80124	VCPIP1	2
4914	NTRK1	2
667	DST	4
115701	ALPK2	5
4004	LMO1	3
83666	PARP9	1
5305	PIP4K2A	2
352909	DNAAF3	5
140803	TRPM6	6
6770	STAR	2
2188	FANCF	3
6146	RPL22	3
2648	KAT2A	1
1950	EGF	4
658	BMPR1B	2
2870	GRK6	3
9344	TAOK2	2
3899	AFF3	7
6498	SKIL	3
7273	TTN	1
1445	CSK	7
171023	ASXL1	1
79834	PEAK1	2
7465	WEE1	1
7059	THBS3	3
7454	WAS	4
10257	ABCC4	2
85415	RHPN2	4
10562	OLFM4	1
8028	MLLT10	3
53904	MYO3A	5
8648	NCOA1	4
387	RHOA	3
3161	HMMR	3
55561	CDC42BPG	5
10249	GLYAT	3
8821	INPP4B	4
22843	PPM1E	3
23305	ACSL6	1
10595	ERN2	5
2072	ERCC4	2
344905	ATP13A5	2
29994	BAZ2B	1
51151	SLC45A2	2
5291	PIK3CB	2
3611	ILK	6
10076	PTPRU	3
558	AXL	2
7248	TSC1	4
332	BIRC5	3
83417	FCRL4	6
57680	CHD8	3
5581	PRKCE	7
317	APAF1	1
2041	EPHA1	2
10111	RAD50	3
100124696	TEC	3
9223	MAGI1	1
860	RUNX2	2
1789	DNMT3B	3
140913	PPIAP10	3
7094	TLN1	5
3181	HNRNPA2B1	1
9659	PDE4DIP	2
9201	DCLK1	4
63976	PRDM16	3
54101	RIPK4	4
283455	KSR2	6
6093	ROCK1	8
3557	IL1RN	3
2130	EWSR1	4
1385	CREB1	4
598	BCL2L1	5
3579	CXCR2	6
5587	PRKD1	1
1719	DHFR	10
5681	PSKH1	3
8317	CDC7	1
10922	FASTK	2
22982	DIP2C	4
7227	TRPS1	8
53335	BCL11A	3
5506	PPP1R3A	6
79837	PIP4K2C	4
3709	ITPR2	4
57147	SCYL3	1
6778	STAT6	2
1906	EDN1	6
27004	TCL6	6
4221	MEN1	3
4067	LYN	2
23301	EHBP1	2
3984	LIMK1	2
8428	STK24	5
4772	NFATC1	6
51562	MBIP	2
3516	RBPJ	4
3552	IL1A	2
80216	ALPK1	5
5915	RARB	1
330	BIRC3	6
4330	MN1	4
84072	HORMAD1	6
23512	SUZ12	4
11076	TPPP	3
7913	DEK	2
8536	CAMK1	1
2122	MECOM	7
51167	CYB5R4	2
1760	DMPK	2
3815	KIT	5
9212	AURKB	1
196528	ARID2	1
5925	RB1	2
4217	MAP3K5	3
4893	NRAS	1
2065	ERBB3	1
25	ABL1	3
10420	TESK2	2
1576	CYP3A4	2
7403	KDM6A	3
54790	TET2	3
2308	FOXO1	1
1432	MAPK14	6
7508	XPC	3
4615	MYD88	3
8841	HDAC3	4
4638	MYLK	3
51364	ZMYND10	3
197259	MLKL	2
4205	MEF2A	2
30849	PIK3R4	2
55959	SULF2	3
171017	ZNF384	3
3480	IGF1R	5
2011	MARK2	4
79728	PALB2	1
23092	ARHGAP26	2
10494	STK25	2
4915	NTRK2	8
55869	HDAC8	3
4299	AFF1	2
11086	ADAM29	4
142	PARP1	5
9262	STK17B	3
2261	FGFR3	7
84197	POMK	2
8711	TNK1	3
4040	LRP6	2
3092	HIP1	2
4763	NF1	6
1994	ELAVL1	2
1840	DTX1	5
440270	GOLGA8B	5
5288	PIK3C2G	7
94	ACVRL1	2
5287	PIK3C2B	2
2280	FKBP1A	3
23683	PRKD3	3
3679	ITGA7	2
10048	RANBP9	4
6943	TCF21	3
1608	DGKG	3
3265	HRAS	2
6868	ADAM17	2
57699	CPNE5	3
56155	TEX14	6
5602	MAPK10	2
2892	GRIA3	5
167359	NIM1K	1
11035	RIPK3	5
4486	MST1R	3
5624	PROC	2
5970	RELA	2
578	BAK1	3
1488	CTBP2	6

Gene in drug-gene network: Network Plot

Models in Tipifarnib

SITE

DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.