NEK9


Summary: This gene encodes a member of the NimA (never in mitosis A) family of serine/threonine protein kinases. The encoded protein is activated in mitosis and, in turn, activates other family members during mitosis. This protein also mediates cellular processes that are essential for interphase progression. [provided by RefSeq, Jul 2016].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
OMIM IDMIM:609798
PHARMGKB IDPA38593
Map Location14q24.3

GO terms in NEK9


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Term Type
Evidence Type
GO Term ID
GO Des.
CC IEA GO:0005634 nucleus
CC IDA GO:0005813 centrosome
CC TAS GO:0005829 cytosol
BP IEA GO:0006468 protein phosphorylation
BP TAS GO:0007077 mitotic nuclear envelope disassembly
BP IEA GO:0051301 cell division
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Gene expression in normal tissue: NEK9

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined34PI3K/MTOR signaling1Stilbenoid, diarylheptanoid and gingerol biosynthesis1DNA replication1Protein stability and degradation1Metabolic pathways1p53 pathway1Other, kinases1Apoptosis regulation1Ferroptosis1

Pathways in NEK9


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Database
Pathway ID
Pathway Des.
reactome R-HSA-1640170 Cell Cycle
reactome R-HSA-2980766 Nuclear Envelope Breakdown
reactome R-HSA-2980767 Activation of NIMA Kinases NEK9, NEK6, NEK7
reactome R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly
reactome R-HSA-68875 Mitotic Prophase
reactome R-HSA-68886 M Phase
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD280 CYTOCHALASIN B 2
iGMDRD639 YK 4-279 3
iGMDRD193 Fqi1 7
iGMDRD446 LY 2183240 2
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in NEK9

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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