NEK9
Summary: This gene encodes a member of the NimA (never in mitosis A) family of serine/threonine protein kinases. The encoded protein is activated in mitosis and, in turn, activates other family members during mitosis. This protein also mediates cellular processes that are essential for interphase progression. [provided by RefSeq, Jul 2016].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| NIMA related kinase 9 | MIM:609798 | Ensembl:ENSG00000119638 | HGNC:HGNC:18591 | PA38593 | 14q24.3 |
GO terms in NEK9
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IEA | GO:0005634 | nucleus |
| CC | IDA | GO:0005813 | centrosome |
| CC | TAS | GO:0005829 | cytosol |
| BP | IEA | GO:0006468 | protein phosphorylation |
| BP | TAS | GO:0007077 | mitotic nuclear envelope disassembly |
| BP | IEA | GO:0051301 | cell division |
| MF | IEA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IPI | GO:0019901 | protein kinase binding |
| MF | IEA | GO:0046872 | metal ion binding |
Gene expression in normal tissue: NEK9
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in NEK9
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-2980766 | Nuclear Envelope Breakdown |
| reactome | R-HSA-2980767 | Activation of NIMA Kinases NEK9, NEK6, NEK7 |
| reactome | R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly |
| reactome | R-HSA-68875 | Mitotic Prophase |
| reactome | R-HSA-68886 | M Phase |
| reactome | R-HSA-69278 | Cell Cycle, Mitotic |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD280 | CYTOCHALASIN B | 2 |
| iGMDRD639 | YK 4-279 | 3 |
| iGMDRD193 | Fqi1 | 7 |
| iGMDRD446 | LY 2183240 | 2 |
| iGMDRD797 | ISOX DUAL | 3 |
| iGMDRD427 | ABT737 | 3 |
| iGMDRD670 | ML 210 | 3 |
| iGMDRD779 | PRL-3 Inhibitor I | 3 |
| iGMDRD599 | Salermide | 3 |
| iGMDRD229 | B02 | 1 |
| iGMDRD126 | Tipifarnib | 2 |
| iGMDRD151 | CHM-1 | 3 |
| iGMDRD433 | Lexibulin | 9 |
| iGMDRD451 | Serdemetan | 4 |
| iGMDRD524 | ISX-9 | 3 |
| iGMDRD64 | Parbendazole | 7 |
| iGMDRD888 | Compound 44 | 3 |
| iGMDRD577 | BIX01294 | 6 |
| iGMDRD506 | Fedratinib | 4 |
| iGMDRD398 | Sepantronium | 1 |
| iGMDRD207 | Capsaicin | 3 |
| iGMDRD782 | DC-45-A2 | 1 |
| iGMDRD260 | FQI-2 | 3 |
| iGMDRD255 | SB225002 | 3 |
| iGMDRD138 | PX 12 | 6 |
| iGMDRD154 | NSC23766 | 3 |
| iGMDRD883 | CIL55A | 1 |
| iGMDRD211 | (1S,3R)-RSL3 | 3 |
| iGMDRD901 | ELCPK | 3 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD237 | ABT-751 | 3 |
| iGMDRD701 | NVP-AUY922 | 3 |
| iGMDRD84 | Lovastatin acid | 3 |
| iGMDRD505 | Pevonedistat | 3 |
| iGMDRD367 | Ro 28-1675 | 3 |
| iGMDRD481 | Dactolisib | 1 |
| iGMDRD77 | Itraconazole | 3 |
| iGMDRD231 | Importazole | 1 |
| iGMDRD6 | AM-580 | 3 |
| iGMDRD434 | BMS-536924 | 2 |
| iGMDRD5 | Tyrphostin AG 1478 | 3 |
| iGMDRD202 | Curcumin | 2 |
| iGMDRD158 | NSC141540 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in NEK9
CLASSFICATION
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