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iGMDRD433

Canonical SMILES: CCCC(C1=CN=CC=C1)NC2=NC(=NC=C2C)C3=CC(=C(C=C3)NC(=O)NCC)OC

InChI: InChI=1S/C24H30N6O2/c1-5-8-19(18-9-7-12-25-15-18)28-22-16(3)14-27-23(30-22)17-10-11-20(21(13-17)32-4)29-24(31)26-6-2/h7,9-15,19H,5-6,8H2,1-4H3,(H2,26,29,31)(H,27,28,30)/t19-/m0/s1

InChI Key: MTJHLONVHHPNSI-IBGZPJMESA-N

Standard Name	CHEMBL	Pubchem CID	Drug Status	Drug Type
Lexibulin	CHEMBL552212	11351000	Alone	Small Molecule

Drug-model tissue-cancer distribution: Bubble Plot

Drug-gene pathway enrichments

Drug-gene GO enrichments

Drug-Gene: Aster Plot

Gene ID	Gene Name	Model Num.
64901	RANBP17	2
1147	CHUK	4
1105	CHD1	2
27125	AFF4	4
8999	CDKL2	5
5027	P2RX7	5
6491	STIL	2
8476	CDC42BPA	1
26191	PTPN22	3
2956	MSH6	2
2200	FBN1	1
57554	LRRC7	2
3845	KRAS	1
4750	NEK1	3
23097	CDK19	3
55215	FANCI	1
8289	ARID1A	4
701	BUB1B	1
2475	MTOR	2
3326	HSP90AB1	3
5133	PDCD1	4
11116	FGFR1OP	1
7444	VRK2	2
390502	SERPINA2	3
10892	MALT1	3
23235	SIK2	4
10863	ADAM28	2
3066	HDAC2	1
55534	MAML3	3
7048	TGFBR2	3
80122	MAP3K19	1
1387	CREBBP	4
1859	DYRK1A	4
11200	CHEK2	4
51755	CDK12	3
3604	TNFRSF9	2
8295	TRRAP	3
10438	C1D	5
7173	TPO	2
55728	N4BP2	5
54477	PLEKHA5	4
57670	KIAA1549	1
440279	UNC13C	2
4301	AFDN	2
84033	OBSCN	3
342977	NANOS3	4
9693	RAPGEF2	1
80351	TNKS2	3
6091	ROBO1	3
2042	EPHA3	2
5330	PLCB2	2
23255	MTCL1	1
730249	ACOD1	3
80129	CCDC170	3
83990	BRIP1	3
4194	MDM4	2
2045	EPHA7	1
287015	TRIM42	3
8643	PTCH2	2
79971	WLS	3
54899	PXK	4
440730	TRIM67	2
783	CACNB2	3
6709	SPTAN1	2
6464	SHC1	2
80243	PREX2	2
28996	HIPK2	3
4087	SMAD2	3
1496	CTNNA2	3
2272	FHIT	2
2066	ERBB4	4
7184	HSP90B1	3
3932	LCK	3
58508	KMT2C	6
7157	TP53	1
6092	ROBO2	2
4173	MCM4	1
4855	NOTCH4	2
2322	FLT3	3
8218	CLTCL1	6
2263	FGFR2	2
130399	ACVR1C	1
1019	CDK4	3
11213	IRAK3	4
55034	MOCOS	3
23043	TNIK	2
4436	MSH2	2
80205	CHD9	1
8997	KALRN	5
632	BGLAP	1
23469	PHF3	3
4089	SMAD4	4
6654	SOS1	3
672	BRCA1	4
11168	PSIP1	1
7204	TRIO	1
10733	PLK4	1
835	CASP2	1
3417	IDH1	3
5297	PI4KA	4
54756	IL17RD	3
4214	MAP3K1	2
602	BCL3	3
50615	IL21R	2
5290	PIK3CA	6
92335	STRADA	3
3720	JARID2	6
26524	LATS2	2
85366	MYLK2	3
675	BRCA2	4
3458	IFNG	3
26166	RGS22	3
607	BCL9	3
7075	TIE1	2
744	MPPED2	3
1956	EGFR	2
2735	GLI1	3
64333	ARHGAP9	1
11064	CNTRL	4
5789	PTPRD	6
8021	NUP214	2
26278	SACS	1
51265	CDKL3	2
7443	VRK1	2
91754	NEK9	9
23005	MAPKBP1	2
203102	ADAM32	4
7153	TOP2A	3
1981	EIF4G1	3
780	DDR1	3
8924	HERC2	3
339345	NANOS2	1
120892	LRRK2	6
6095	RORA	2
8029	CUBN	4
8626	TP63	2
55521	TRIM36	3
10752	CHL1	3
23476	BRD4	1
4914	NTRK1	3
22883	CLSTN1	2
667	DST	4
115701	ALPK2	2
6770	STAR	3
177	AGER	3
3899	AFF3	3
7273	TTN	4
7059	THBS3	3
85415	RHPN2	1
10562	OLFM4	3
54904	NSD3	3
387	RHOA	2
54861	SNRK	3
55561	CDC42BPG	3
10249	GLYAT	2
286151	FBXO43	3
26686	OR4E2	3
7248	TSC1	2
9748	SLK	3
4619	MYH1	3
57680	CHD8	3
5562	PRKAA1	3
1399	CRKL	3
2317	FLNB	3
10111	RAD50	3
1281	COL3A1	6
9659	PDE4DIP	5
54101	RIPK4	3
6760	SS18	3
5927	KDM5A	6
5589	PRKCSH	4
57448	BIRC6	1
3717	JAK2	3
2157	F8	2
3977	LIFR	1
2122	MECOM	2
63923	TNN	1
4638	MYLK	6
30849	PIK3R4	2
2261	FGFR3	5
23072	HECW1	3
55422	ZNF331	5
4763	NF1	2
2044	EPHA5	1
4593	MUSK	3
30811	HUNK	2
81788	NUAK2	1
23112	TNRC6B	2
2178	FANCE	1
2892	GRIA3	3

Gene in drug-gene network: Network Plot

Models in Lexibulin

SITE

DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.