NOTCH4
Summary: This gene encodes a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types. Notch signaling is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells through binding of Notch family receptors to their cognate ligands. The encoded preproprotein is proteolytically processed in the trans-Golgi network to generate two polypeptide chains that heterodimerize to form the mature cell-surface receptor. This receptor may play a role in vascular, renal and hepatic development. Mutations in this gene may be associated with schizophrenia. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| notch 4 | MIM:164951 | Ensembl:ENSG00000204301 | HGNC:HGNC:7884 | PA31686 | 6p21.32 |
GO terms in NOTCH4
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | TAS | GO:0000139 | Golgi membrane |
| CC | TAS | GO:0005576 | extracellular region |
| CC | TAS | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005789 | endoplasmic reticulum membrane |
| CC | TAS | GO:0005829 | cytosol |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005887 | integral component of plasma membrane |
| CC | IDA | GO:0009986 | cell surface |
| BP | ISS | GO:0001569 | branching involved in blood vessel morphogenesis |
| BP | TAS | GO:0001709 | cell fate determination |
| BP | ISS | GO:0001763 | morphogenesis of a branching structure |
| BP | IEA | GO:0001886 | endothelial cell morphogenesis |
| BP | ISS | GO:0001944 | vasculature development |
| BP | TAS | GO:0006367 | transcription initiation from RNA polymerase II promoter |
| BP | TAS | GO:0007219 | Notch signaling pathway |
| BP | TAS | GO:0007221 | positive regulation of transcription of Notch receptor target |
| BP | TAS | GO:0030097 | hemopoiesis |
| BP | NAS | GO:0030154 | cell differentiation |
| BP | IDA | GO:0030879 | mammary gland development |
| BP | IEA | GO:0042060 | wound healing |
| BP | NAS | GO:0045596 | negative regulation of cell differentiation |
| BP | ISS | GO:0045602 | negative regulation of endothelial cell differentiation |
| BP | TAS | GO:0045893 | positive regulation of transcription, DNA-templated |
| MF | TAS | GO:0005509 | calcium ion binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | TAS | GO:0038023 | signaling receptor activity |
| MF | TAS | GO:0046982 | protein heterodimerization activity |
Gene expression in normal tissue: NOTCH4
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in NOTCH4
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04330 | Notch signaling pathway - Homo sapiens (human) |
| kegg | hsa04919 | Thyroid hormone signaling pathway - Homo sapiens (human) |
| kegg | hsa05165 | Human papillomavirus infection - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05206 | MicroRNAs in cancer - Homo sapiens (human) |
| kegg | hsa05224 | Breast cancer - Homo sapiens (human) |
| pid | notch_pathway | Notch signaling pathway |
| netpath | Pathway_Notch | Notch |
| wikipathways | WP2064 | Neural Crest Differentiation |
| wikipathways | WP268 | Notch Signaling Pathway |
| wikipathways | WP3845 | Canonical and Non-canonical Notch signaling |
| wikipathways | WP3888 | VEGFA-VEGFR2 Signaling Pathway |
| wikipathways | WP3971 | Role of Osx and miRNAs in tooth development |
| wikipathways | WP4239 | EMT transition in Colorectal Cancer |
| wikipathways | WP4242 | Notch Signaling Pathway |
| wikipathways | WP61 | Notch Signaling Pathway |
| reactome | R-HSA-157118 | Signaling by NOTCH |
| reactome | R-HSA-157118 | Signaling by NOTCH |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-1912399 | Pre-NOTCH Processing in the Endoplasmic Reticulum |
| reactome | R-HSA-1912408 | Pre-NOTCH Transcription and Translation |
| reactome | R-HSA-1912420 | Pre-NOTCH Processing in Golgi |
| reactome | R-HSA-1912420 | Pre-NOTCH Processing in Golgi |
| reactome | R-HSA-1912422 | Pre-NOTCH Expression and Processing |
| reactome | R-HSA-1912422 | Pre-NOTCH Expression and Processing |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-350054 | Notch-HLH transcription pathway |
| reactome | R-HSA-3781865 | Diseases of glycosylation |
| reactome | R-HSA-3906995 | Diseases associated with O-glycosylation of proteins |
| reactome | R-HSA-5083630 | Defective LFNG causes SCDO3 |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-9013694 | Signaling by NOTCH4 |
| reactome | R-HSA-9013694 | Signaling by NOTCH4 |
| reactome | R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription |
| reactome | R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription |
| reactome | R-HSA-9013700 | NOTCH4 Activation and Transmission of Signal to the Nucleus |
| reactome | R-HSA-9013700 | NOTCH4 Activation and Transmission of Signal to the Nucleus |
| reactome | R-HSA-9604323 | Negative regulation of NOTCH4 signaling |
| reactome | R-HSA-9604323 | Negative regulation of NOTCH4 signaling |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD5 | Tyrphostin AG 1478 | 1 |
| iGMDRD227 | Fatostatin A | 2 |
| iGMDRD202 | Curcumin | 2 |
| iGMDRD137 | Indisulam | 5 |
| iGMDRD481 | Dactolisib | 3 |
| iGMDRD434 | BMS-536924 | 2 |
| iGMDRD523 | Cyanoquinoline, 11 | 5 |
| iGMDRD351 | GW843682X | 1 |
| iGMDRD341 | Triacsin c | 6 |
| iGMDRD945 | ML214 | 1 |
| iGMDRD901 | ELCPK | 2 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD260 | FQI-2 | 3 |
| iGMDRD513 | BML-259 | 1 |
| iGMDRD138 | PX 12 | 2 |
| iGMDRD885 | Compound 110 | 3 |
| iGMDRD187 | BRD9876 | 4 |
| iGMDRD506 | Fedratinib | 2 |
| iGMDRD562 | Navitoclax | 2 |
| iGMDRD100 | Zebularine | 4 |
| iGMDRD188 | Piperlongumine | 2 |
| iGMDRD399 | Selumetinib | 5 |
| iGMDRD268 | Cerulenin | 2 |
| iGMDRD524 | ISX-9 | 3 |
| iGMDRD64 | Parbendazole | 3 |
| iGMDRD433 | Lexibulin | 2 |
| iGMDRD151 | CHM-1 | 3 |
| iGMDRD483 | SCH-529074 | 2 |
| iGMDRD193 | Fqi1 | 4 |
| iGMDRD375 | GW-405833 | 1 |
| iGMDRD359 | OSW-1 | 3 |
| iGMDRD466 | Chaetocin | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in NOTCH4
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