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iGMDRD202

Canonical SMILES: COC1=C(C=CC(=C1)C=CC(=O)CC(=O)C=CC2=CC(=C(C=C2)O)OC)O

InChI: InChI=1S/C21H20O6/c1-26-20-11-14(5-9-18(20)24)3-7-16(22)13-17(23)8-4-15-6-10-19(25)21(12-15)27-2/h3-12,24-25H,13H2,1-2H3/b7-3+,8-4+

InChI Key: VFLDPWHFBUODDF-FCXRPNKRSA-N

Standard Name	CHEMBL	Pubchem CID	DRUGBANK ID	Drug Status	Drug Type
Curcumin	CHEMBL140	969516	DB11672	Alone	Small Molecule

Drug Class:

Alkanes Analgesics Analgesics, Non-Narcotic Anti-Inflammatory Agents Antineoplastic Agents Antirheumatic Agents Benzene Derivatives Catechols Central Nervous System Agents Coloring Agents Combined Inhibitors of CYP3A4 and P-glycoprotein Combined Inhibitors of CYP3A4 and P-glycoprotein (Strong)Cytochrome P-450 CYP1A2 Inhibitors Cytochrome P-450 CYP1A2 Inhibitors (moderate)Cytochrome P-450 CYP2B6 Inhibitors Cytochrome P-450 CYP2B6 Inhibitors (moderate)Cytochrome P-450 CYP2C9 Inhibitors Cytochrome P-450 CYP2C9 Inhibitors (strong)Cytochrome P-450 CYP2D6 Inhibitors Cytochrome P-450 CYP2D6 Inhibitors (moderate)Cytochrome P-450 CYP3A Inhibitors Cytochrome P-450 CYP3A Inhibitors (strong)Cytochrome P-450 CYP3A4 Inhibitors Cytochrome P-450 CYP3A4 Inhibitors (strong)Cytochrome P-450 Enzyme Inhibitors Diarylheptanoids Enzyme Inhibitors Heptanes Hydrocarbons Hydrocarbons, Acyclic Hydrocarbons, Aromatic Hydrocarbons, Cyclic P-glycoprotein/ABCB1 Inhibitors P-glycoprotein/ABCB1 Substrates Peripheral Nervous System Agents Phenols Sensory System Agents Specialty Uses of Chemicals

Drug Targets:

PPARG (P37231)VDR (P11473)ABCC5 (O15440)CBR1 (P16152)GSTP1 (P09211)

Drug Pathways:

Stilbenoid, diarylheptanoid and gingerol biosynthesis Biosynthesis of secondary metabolites

Drug-model tissue-cancer distribution: Bubble Plot

Drug-gene pathway enrichments

Drug-gene GO enrichments

Drug-Gene: Aster Plot

Gene ID	Gene Name	Model Num.
331	XIAP	5
64901	RANBP17	4
1147	CHUK	4
7514	XPO1	1
8999	CDKL2	1
7074	TIAM1	3
79054	TRPM8	3
7128	TNFAIP3	2
5933	RBL1	2
26191	PTPN22	3
2200	FBN1	2
1520	CTSS	3
1969	EPHA2	4
7272	TTK	3
3845	KRAS	2
23097	CDK19	4
8289	ARID1A	3
80070	ADAMTS20	3
8266	UBL4A	1
3939	LDHA	3
79092	CARD14	3
2475	MTOR	1
9475	ROCK2	2
83942	TSSK1B	2
4036	LRP2	3
7764	ZNF217	5
10395	DLC1	3
3069	HDLBP	3
83481	EPPK1	1
390502	SERPINA2	4
56776	FMN2	3
10892	MALT1	1
1607	DGKB	2
3694	ITGB6	6
22853	LMTK2	3
7253	TSHR	5
7098	TLR3	1
10645	CAMKK2	4
8749	ADAM18	5
55534	MAML3	3
8737	RIPK1	3
9816	URB2	3
7048	TGFBR2	4
54822	TRPM7	6
51199	NIN	3
1813	DRD2	6
1387	CREBBP	3
8106	PABPN1	3
2043	EPHA4	2
5788	PTPRC	3
2313	FLI1	3
56164	STK31	5
31	ACACA	5
10178	TENM1	1
51755	CDK12	2
79858	NEK11	4
9048	ARTN	6
8295	TRRAP	5
10438	C1D	5
27148	STK36	3
2120	ETV6	2
5314	PKHD1	6
139378	ADGRG4	3
89910	UBE3B	1
55294	FBXW7	2
8030	CCDC6	6
9578	CDC42BPB	4
10746	MAP3K2	3
23522	KAT6B	3
57670	KIAA1549	2
22861	NLRP1	4
440279	UNC13C	7
256646	NUTM1	2
2051	EPHB6	3
9693	RAPGEF2	1
3556	IL1RAP	4
329	BIRC2	3
4300	MLLT3	2
8396	PIP4K2B	4
6041	RNASEL	3
80351	TNKS2	4
8313	AXIN2	3
2042	EPHA3	2
51343	FZR1	3
730249	ACOD1	6
80129	CCDC170	5
10188	TNK2	4
9636	ISG15	6
2908	NR3C1	4
83990	BRIP1	1
51804	SIX4	2
4739	NEDD9	3
55681	SCYL2	3
2045	EPHA7	3
23405	DICER1	2
171019	ADAMTS19	3
287015	TRIM42	6
57476	GRAMD1B	1
26750	RPS6KC1	3
7486	WRN	2
1456	CSNK1G3	2
783	CACNB2	4
5580	PRKCD	3
6416	MAP2K4	1
1452	CSNK1A1	2
8714	ABCC3	3
6709	SPTAN1	6
8215	DVL1P1	3
1909	EDNRA	2
50488	MINK1	2
5591	PRKDC	3
8859	STK19	1
6098	ROS1	3
3685	ITGAV	2
80243	PREX2	1
2580	GAK	6
28996	HIPK2	1
53942	CNTN5	5
4087	SMAD2	4
6792	CDKL5	3
1496	CTNNA2	2
7010	TEK	5
5450	POU2AF1	6
5327	PLAT	5
7184	HSP90B1	4
1910	EDNRB	3
3236	HOXD10	2
5834	PYGB	1
58508	KMT2C	2
2099	ESR1	4
6092	ROBO2	6
7704	ZBTB16	3
4088	SMAD3	3
4855	NOTCH4	2
6794	STK11	5
2322	FLT3	6
54498	SMOX	6
130399	ACVR1C	3
1019	CDK4	1
11213	IRAK3	3
1045	CDX2	1
5604	MAP2K1	3
4869	NPM1	2
863	CBFA2T3	3
8874	ARHGEF7	3
1555	CYP2B6	4
55034	MOCOS	2
23043	TNIK	3
4921	DDR2	4
5077	PAX3	2
57188	ADAMTSL3	1
3187	HNRNPH1	1
65125	WNK1	7
136332	LRGUK	2
4436	MSH2	2
50945	TBX22	3
676	BRDT	3
7175	TPR	3
80205	CHD9	1
10499	NCOA2	6
8997	KALRN	3
3643	INSR	3
57111	RAB25	1
57551	TAOK1	2
23469	PHF3	2
672	BRCA1	1
2060	EPS15	3
7204	TRIO	1
9448	MAP4K4	3
546	ATRX	5
3417	IDH1	2
5297	PI4KA	1
10769	PLK2	3
30827	CXXC1	1
8216	LZTR1	1
3702	ITK	4
3239	HOXD13	3
1687	GSDME	5
8202	NCOA3	3
5045	FURIN	3
10565	ARFGEF1	1
64919	BCL11B	3
4803	NGF	3
7075	TIE1	2
640	BLK	1
841	CASP8	3
11064	CNTRL	9
64750	SMURF2	5
1459	CSNK2A2	6
26278	SACS	6
894	CCND2	3
29951	PDZRN4	3
51265	CDKL3	3
3553	IL1B	6
5592	PRKG1	4
1594	CYP27B1	6
5747	PTK2	6
5156	PDGFRA	2
91754	NEK9	2
84630	TTBK1	3
1213	CLTC	4
3315	HSPB1	6
23532	PRAME	1
780	DDR1	4
57538	ALPK3	3
8924	HERC2	2
65268	WNK2	3
867	CBL	3
6095	RORA	3
8029	CUBN	9
5128	CDK17	3
8626	TP63	2
9113	LATS1	2
460	ASTN1	2
7849	PAX8	6
5979	RET	3
9321	TRIP11	1
9451	EIF2AK3	2
654780	LOC654780	6
8491	MAP4K3	3
55521	TRIM36	3
10752	CHL1	6
57521	RPTOR	3
5595	MAPK3	2
1869	E2F1	6
22883	CLSTN1	2
667	DST	4
3554	IL1R1	9
23542	MAPK8IP2	3
2324	FLT4	6
658	BMPR1B	1
5896	RAG1	3
3899	AFF3	1
8522	GAS7	4
5582	PRKCG	8
7059	THBS3	3
55356	SLC22A15	3
85415	RHPN2	5
203447	NRK	3
2277	VEGFD	2
54904	NSD3	1
53904	MYO3A	6
54861	SNRK	1
2046	EPHA8	3
128869	PIGU	3
7150	TOP1	3
8805	TRIM24	2
22843	PPM1E	1
286151	FBXO43	2
26686	OR4E2	6
344905	ATP13A5	2
51151	SLC45A2	3
5291	PIK3CB	6
9748	SLK	6
4774	NFIA	6
5395	PMS2	2
860	RUNX2	6
53353	LRP1B	6
1281	COL3A1	6
9201	DCLK1	1
6760	SS18	5
3624	INHBA	3
5927	KDM5A	3
3579	CXCR2	3
57007	ACKR3	6
3717	JAK2	2
22982	DIP2C	2
7099	TLR4	3
7227	TRPS1	2
53335	BCL11A	3
5506	PPP1R3A	3
6778	STAT6	2
65267	WNK3	6
6777	STAT5B	4
5932	RBBP8	1
330	BIRC3	3
182	JAG1	3
51167	CYB5R4	3
5925	RB1	2
4893	NRAS	3
862	RUNX1T1	3
8661	EIF3A	9
7403	KDM6A	1
1234	CCR5	2
2534	FYN	3
4205	MEF2A	6
4299	AFF1	3
11086	ADAM29	6
9262	STK17B	3
55422	ZNF331	6
4763	NF1	3
8814	CDKL1	2
57697	FANCM	1
10891	PPARGC1A	1
2044	EPHA5	3
4593	MUSK	1
4629	MYH11	6
814	CAMK4	3
3679	ITGA7	2
27255	CNTN6	3
83732	RIOK1	3
2444	FRK	2
2892	GRIA3	3
5624	PROC	2

Gene in drug-gene network: Network Plot

Models in Curcumin

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DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.